Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"antiviral factors"”.
-
Characterisation of Novel Secreted Antiviral Factors to Human Cytomegalovirus
… to a multitude of virally-encoded immune evasion factors. The broad immune response raised against the virus includes the action of intrinsic antiviral restriction factors, NK cells, neutralising antibodies and polyfunctional CD4+ and CD8+ T-cells. Although critical roles have been established for …
-
The Elucidation of the Mechanisms of CD8+ T Cell-Mediated Suppression of Human Immunodeficiency Virus Type 1 Replication
… of CD8<super>+</super> T-lymphocyte noncytolytic antiviral response (CNAR). This response is comprised of 3 key components, the virus, the effector cell and the target cell, each of which contribute to noncytolytic suppression. During the course of CNAR, the effector cells express antiviral …
-
Genetic variation in the IFITM locus and its phenotypic consequences
… proteins have been identified as important antiviral factors. The current understanding of IFITMs suggests that they localise within distinct cellular compartments from where they exert their broad antiviral role. For example, IFITM1 localises to the plasma membrane and restricts viruses …
-
Prenylation in cell-intrinsic innate immunity to positive-strand RNA viruses
Cell intrinsic antiviral immunity is a critical facet of the innate immune response to viruses. Since virtually every subcellular compartment can be utilized by viruses for replication, antiviral factors must also be positioned in these compartments to effectively interact with various viral …
-
The Interferon Stimulated Gene Product Lymphocyte Antigen 6 Complex, Locus E Promotes Entry of a Subset of Diverse RNA Viruses and Inhibits Infection by Coronaviruses
Interferons (IFNs) contribute to cell-intrinsic antiviral immunity by inducing hundreds of IFN-stimulated genes (ISG). In a screen to identify novel antiviral factors, the Schoggins lab unexpectedly uncovered a subset of genes that enhanced viral infection. Here, I describe my personal efforts to …
-
The Impact of Host Factors on Retroviral Evolution and the Identification of a Novel Receptor That Was Used by an Ancient Primate Retrovirus
… gorillas, and chimpanzees. It is possible that antiviral proteins were able to protect human ancestors from colonization by CERV1 and CERV2. Indeed, sequence analyses of modern primate restriction factors has suggested that these genes have evolved under positive selection, presumably due to …
-
UNDERSTANDING PLACENTAL IMMUNITY: CYTOKINE CONTROL OF CONGENITAL VIRAL INFECTION
… defenses including the constitutive secretion of antiviral factors called cytokines. Previous work has identified antiviral cytokines in the placenta that restrict congenital viral infections without inducing excessive inflammation or immune pathology, such as Type III interferons (IFNλ). However, …
-
Identification and Characterisation of Human Cytomegalovirus-Mediated Degradation of Helicase-Like Transcription Factor
Viruses are known to degrade host factors that are important in innate antiviral immunity in order to infect successfully. To systematically identify host proteins targeted for early degradation by human cytomegalovirus (HCMV), the lab developed orthogonal screens using high resolution multiplexed …
-
Functional and Mechanistic Analysis of Protein Degradation by Human Cytomegalovirus to Uncover Viral Immune Evasion Mechanisms
… virus-host coevolution, viruses often antagonise antiviral host proteins by driving their downregulation, mislocalisation or inactivation. A quantitative proteomic analysis of HCMV infection published by our group found that at least 133 proteins are likely targeted for degradation by HCMV during …
-
Mechanism and Evolutionary Origins of HIV-1 Virion Entrapment by Tetherin
… we demonstrated that PV1 can be endowed with antiviral activity against HIV-1 when it is engineered to encode a C-terminal GPI anchor. Although we did not detect any sequence homology between PV1 and tetherin, in silico evolution experiments indicated that it is possible to evolve sequences …