Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"antiviral defense"”.
-
Small RNA-based antiviral defense in insects
Contains fulltext : 131645.pdf (Publisher’s version ) (Open Access)
-
Elucidating the molecular mechanisms of antiviral defense systems
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
-
Discovery and engineering of antiviral defense systems in bacteria and archaea
… have acquired a potent arsenal of molecular defense systems in order to survive. Known defense systems, such as CRISPR, have given rise to transformative technologies including genome editing. However, defense systems as a whole remain underexplored. Continued investigation of these systems …
-
The tomato RLK superfamily: phylogeny and functional predictions about the role of the LRRII- RLK subfamily in antiviral defense
… ou para um hospedeiro. Portanto, a sinalização antiviral mediado por NIK provavelmente ocorre em tomate, sugerindo que NIKs de tomate sejam alvos potenciais para manipular a resistência contra begomovírus que infectam esta planta.
-
Functional characterization of human and chicken TLR3
… making TLR3 an important mediator of early antiviral defense. Notably, naturally occurring polymorphisms in chicken TLR3 (chTLR3) have been identified, but their functional significance remains unexplored. This thesis sets the foundation for investigating the impact of chTLR3 polymorphisms …
-
Ancient Immune Systems: Sensing and Signaling in Bacterial-Phage Conflict
… led to an extraordinary diversity of bacterial defense mechanisms [1]. These systems are thought to have provided the evolutionary foundation for numerous eukaryotic immune strategies [2]. Experimental studies have validated many of these anti-phage defense systems and revealed the mechanisms by …
-
Identification and Characterization of Interferon-Stimulated Regulators of Bacterial Infection
… activated transcriptional response is a critical antiviral defense mechanism, yet its role in bacterial pathogenesis remains less well characterized. Using an intracellular pathogen Listeria monocytogenes as a model bacterial pathogen, I sought to identify the roles of individual …
-
The Role of Endogenous Arabidopsis Proteins In Rna Silencing and Hc-Pro-Mediated Suppression of Silencing
… RNA degradation pathway that acts as an antiviral defense pathway. Viruses have evolved suppressors of RNA silencing, including the potyviral protein Helper Component-Proteinase (HC-Pro). Our focus on evaluating the mechanism of HC-Pro function has led us to the discovery of several …
-
EVOLUTIONARY AND MECHANISTIC INTERACTIONS IN VIRUS TRANSMISSION BY APHIDS
… interaction, plant hosts activate their immune defenses against plant viruses and aphids and the latter two use a myriad of strategies to overcome, counteract or skip the host plant defense, which sometimes is done in collaboration. Bacterial endosymbionts of insect vectors might also play a …
-
Characterizing global gene expression and antiviral response in Frankliniella occidentalis infected with Tomato spotted wilt virus
… vectors of orthotospoviruses, ii) the role of antiviral defense in viruliferous thrips, and iii) plant transgenic-based strategies for studying thrips gene function and crop-pest control. To this end, my specific research objectives were to: 1) generate, assemble, and annotate a RNA-Seq-derived …
-
MUCIN-MEDIATED AND INTERFERON-DRIVEN DEFENSE MECHANISMS AGAINST INFLUENZA VIRUS INFECTION IN HUMAN AIRWAY EPITHELIUM
… that promote the establishment of a local antiviral state through autocrine and paracrine signaling. However, despite these protective measures, IAV continues to cause significant annual morbidity and mortality across the globe. Therefore, we sought to further investigate how specific mucin …
-
Characterisation of HP1γ in mammalian cells
… identified increased expression of interferon/antiviral defense genes and activation of pro-apoptotic pathways. Whilst genes involved in these pathways were not directly bound by HP1γ, this analysis also identified HP1γ as a novel regulator of zinc finger (ZNF) genes. In summary, I identified …
-
Regulatory Mechanism of the RNAi Pathway
… that La is required for efficient RNAi, antiviral defense, and transposon silencing in mammalian and Drosophila cells. Taken together, our findings of C3PO and La reveal a general concept that regulatory factors are required to remove Ago2-cleaved products to assemble or restore active …
-
Evasion of RIG-I/MDA5 and TLR3-mediated innate immunity by hepatitis A virus
… genes (ISGs) that ultimately establish an antiviral state. These signaling pathways are central to host antiviral defense and thus become targets for viral interference. Hepatitis A virus (HAV), a hepatotropic picornavirus, is capable of blocking IRF3 activation and type I IFN expression in …
-
Modulation of Alphaviruses by Small RNAs
… rely on small RNA pathways as an adaptive antiviral defense. The canonical antiviral response in these organisms involves dicer enzymes that cleave viral double-stranded RNA replicative intermediates (RIs) into small interfering RNAs (siRNAs; ~21-24 nucleotides). One strand of the siRNA …
-
Reading Between the Strands: Deciphering Double Stranded RNA-Based Immune Responses in Mosquito-Virus Interactions
… to viral infection remain poorly understood. Antiviral immunity in mosquitoes is initiated by the recognition of viral pathogen-associated molecular patterns, with double-stranded RNA (dsRNA), a replication intermediate of many viruses, serving as a key immunostimulatory signal. While RNA …
-
New Roles for Mitochondria in Shaping Antiviral and Stress Responses
… production with now appreciated roles in immune defense. During microbial infection, mitochondria serve as signaling hubs to induce immune responses to counteract invading pathogens like viruses. Mitochondrial functions are central to a variety of antiviral responses including apoptosis and type …
-
Identification and Characterization of Novel Caenorhabditis Nematode Viruses
… and may play a previously undescribed role in antiviral defense. The discovery and characterization of these novel Caenorhabditis nematode viruses lay the groundwork for the introduction of C. elegans as a powerful model organism to study virus-host interactions.</p>
-
Elucidating the Role of Phospholipid Scramblase 1 in Antiviral Innate Immunity
<p>Hosts possess an array of defenses against pathogens, some of which form a baseline protective barrier against infection. This baseline resistance, or intrinsic immunity, is the first layer of cellular defense that a virus must evade or antagonize in order to infect a cell. Intrinsic immunity …
-
Investigation of Diverse CARF Effectors in Type III CRISPR - Cas Immunity
… activation and alone is sufficient to provide antiviral immunity. Lastly, I studied the role of canonical CARF effector Csm6. I genetically dissected the nuclease activity of Cas10 and the RNase activity of Csm6 in the type III CRISPR response and demonstrated that Csm6 is more often required …
Page 1 of 2