Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"antiviral activity"”.
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Characterization and Reconstitution of S-Palmitoylated IFITM3 Antiviral Activity
… to the cell cytoplasm. Despite this broad antiviral activity, the exact mechanism of IFITM3 viral fusion interference, and whether it directly interacts with the fusion environment remains unknown. To better understand the physiological conditions of IFITM3 antiviral activity, we required …
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Characterization of the antiviral activity of cyclosporine A against dengue virus
… to rise to 6.1 billion by 2080, yet no specific antiviral treatments are available despite 80 years of research. Cyclosporine A (CsA), an immunosuppressive drug, has emerged as a potential broad-spectrum antiviral effective against various RNA and DNA viruses, including DENV. However, its …
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The ancient and recurrent evolution of Apobec3 antiviral activity in primates
… and retrotransposons. Here, I characterize the antiviral activity of Apobec3DE across primate species and of Apobec3 family members across human populations. First, I show that human and chimpanzee orthologues of Apobec3DE inhibit retrotransposons that are currently active in hominids. …
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Antiviral activity of 3D8 single chain Fv against RNA virus infection
… variable fragment (scFv) has cell-penetrating activity by electrostatic interaction with cellular membrane and it localizes in cytosol resulting in cell death by cellular rRNA degradation. These result mean that 3D8 scFv would also have potential activity as an intracellular antiviral antibody. …
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In vitro characterization of the antiviral activity of Secomet V against vaccinia virus infections
… bioreactor from primary plant stem cells, whose antiviral activity has been widely reported in folklore medicine. It exerted its anti-vaccinia virus activity by neutralizing cell-free virus rather than interfering with the downstream events following adsorption.
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Antiviral potential of hadjod (Cissus quadrangularis) extract against newcastle disease virus.
… and disorders. The study aimed to evaluate the antiviral activity of crude extracts of C. quadrangularis against NDV. Nine-day-old embryonated chicken eggs were divided into ten groups (n=10) and received various treatments. Six groups were inoculated with Velogenic NDV (vNDV) isolate AF2 and …
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Design and synthesis of HIV-1 integrase inhibitors
… many of these compounds are toxic, do not show antiviral activity or display decreased potency. Therefore, new classes of potent IN inhibitors are desperately needed. The b-diketo (b-DK) class of compounds has emerged as one of the most successful classes of IN inhibitors. Although several b-DK …
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Antiviral activities of selected Chinese medicinal plants
… of China were collected and screened for antiviral activity. Plants that were used to treat diseases that are now known to have viral causes were selected through a systematic survey of information on traditional Chinese medicine and the traditional medicines of ethnic minority groups in …
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Investigating Interferon-Inducible Antiviral Effectors Through a Virological and Evolutionary Lens
… (ISGs). The field has focused on identifying antiviral ISG effectors and defining their mechanisms of action. However, fundamental gaps in knowledge about the interferon response remain. For example, it is unknown how many ISGs are required to restrict a particular virus, though it is …
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Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir
… but also affect their daily life. Often, these antiviral agents are administered along with steroids to reduce the corneal inflammation. Application of ointments and gels restrict the concomitant usage of topical steroids solutions. To address the above issues, goals were set to prepare high …
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Functional stability of a nucleic acid-hydrolyzing single chain antibody in various biochemical and biophysical environments
… fragment (scFv) antibody has cell-penetrating activity, nucleic acid-binding activity, nucleic acid-hydrolyzing activity, and antiviral activity. As a first step toward development of antiviral reagent using 3D8 scFv, functional stability based on DNA-binding and -hydrolyzing activity of 3D8 …
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Studio dell’attività antivirale e/o anti-infiammatoria di nuove molecole di sintesi e/o di farmaci noti
… control of neuroinflammation (Part II). Part I - Antiviral activity of quinoxalines derivates as new leads against Picornavirus Aim: New quinoxaline derivatives were synthesized and tested for cytotoxicity and antiviral activity against human coxsackie virus B5 [CVB-5] and polio virus type-1 …
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Suppressive effect of a nucleic acid-hydrolyzing recombinant antibody (3D8) on viral multiplication
… out quantitative and qualitative analyses of antiviral activity of 3D8 scFv against vesicular stomatitis virus (VSV) that belongs to RNA viruses in HeLa cells. When the purified 3D8 scFv was directly imported into HeLa cells by an electroporation and the cells were infected with VSV (MOI=10), …
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Prenylation in cell-intrinsic innate immunity to positive-strand RNA viruses
Cell intrinsic antiviral immunity is a critical facet of the innate immune response to viruses. Since virtually every subcellular compartment can be utilized by viruses for replication, antiviral factors must also be positioned in these compartments to effectively interact with various viral …
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A nutriceutical approach to inhibiting H1N1 influenza infection
… infectious disease. Some of this protective activity is clearly due to the immune component of breast milk; however, the non-immune component, especially human milk oligosaccharides (HMO) are also thought contribute to antimicrobial activity. Human milk containsa large variety of …
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Pharmacology of novel approaches designed to target picornaviral infections
… berries are cheap, and some extracts have proven antiviral activity. The aim of this project was to repurpose known drugs, approved and used for several years for various medical indications, as well as identify new compounds from natural sources. Coxsackievirus A9 (CAV9) was used as a typical …
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Counteracting Neuroinvasive RNA Viruses: Antiviral and Immune Modulation Strategies Against SARS-CoV-2 and VEEV
… Silicon nitride exhibited antimicrobial activity reducing the likelihood of post-surgical complications due to infection. Our overarching research goal is to test silicon nitride's antiviral activity for potential future integration into PPE for non-pharmaceutical countermeasure use. We …
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Identification and mode of action studies of new potent inhibitors of the RNA viruses HCV, BVDV and RSV
… by RNA viruses. For this reason, research in the antiviral chemotherapy field is directed toward the development of compounds that target various steps of the virus life cycle. In this work the antiviral activity of 5-Acetyl-2- Arylbenzimidazoles and 2-[(benzotriazol-1/2 yl)methyl]benzimidazoles …
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Synthetic Studies in the Didemnin Series
… in the side chain for investigating structure-activity relationships have been performed. The syntheses of several known didemnins including didemnin M, dehydrodidemnin B, and pyroglutamyl didemnin B have been successfully completed. In addition, several new didemnin analogues have been …
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