Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"antitumor efficacy"”.
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Immunostimulatory activity and antitumor efficacy of mSOT201 immunocytokine
… by dose-dependent systemic toxicity and low efficacy. Here, we evaluated mSOT201 immunocytokine consisting of an IL-15 mutein linked through short flexible oligopeptide linker to IL-15Rα sushi+ domain and fused to the C-terminus of anti-mouse PD-1 mAb, thereby directing the cytokine payload …
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Balancing Antitumor Efficacy and Safety Profile: α-Amanitin-Based Fc-Small Molecule Drug Conjugates for Targeted Prostate Cancer Therapy
… linker. This conjugate showed good in vivo efficacy; however, because of the low tolerability, the therapeutic index (TI) was low (=1). To increase the tolerability, this work focused on the unspecific uptake of the conjugates in healthy tissues and their plasma stability. Previous studies …
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Metabolic engineering for the biosynthesis of methylated flavonoids in the microbial factory Streptomyces albidoflavus. Evaluation of the antitumor efficacy of flavonoids in a rat model of colorectal cancer
Durante esta tesis doctoral se ha logrado la biosíntesis heteróloga de varios flavonoides metilados que muestran propiedades interesantes relacionadas con la industria o la salud humana. Específicamente, se ha logrado la biosíntesis de los flavonoides metilados sakuranetina, acetina, genkwanina, …
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Development and Evaluation of Paclitaxel-Loaded Liposomal Formulations for Targeted Drug Delivery to Breast Cancer
… rapidly by the reticuloendothelial system. The antitumor efficacy of paclitaxel-loaded tumor vasculature targeted LCL was compared with paclitaxel-loaded tumor cell targeted LCL. The antitumor efficacy was comparable for tumor vasculature targeted LCL, non-targeted LCL, and paclitaxel solution …
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Simultaneous Induction of Nkg2D and Nkg2D Ligand For Promoting Immune Surveillance By Il-12 Plus Doxorubicin Treatment
… by antigen presenting cells, has remarkable antitumor effect by activating innate and adaptive immunity. Doxorubicin, a commonly used chemotherapeutic agent also boosts the host antitumor immune response to cause tumor cell death. Our previous publication suggests that IL-12 plus doxorubicin …
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Combined Inhibition of Ddr1 and Cdk4/6 Induces Synergistic Effects In Er-Positive, Her2-Negative Breast Cancer With Pik3Ca/Akt1 Mutations
… partners that can enhance palbociclib’s antitumor efficacy in ER-positive breast cancer with PI3K pathway alterations.</p> <p>Using ER-positive isogenic breast cancer cell lines, we demonstrated that the efficacy of palbociclib is attenuated in the presence of <em>PIK3CA </em>or<em> …
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Anti-Gd2 Etoposide-Loaded Immunoliposomes For The Treatment of Gd2 Positive Tumors
… in animals to examine the biodistribution and antitumor effects of immunoliposome mediated etoposide therapy. Fluorescent liposomes were observed at the tumor site with <em>in vivo</em> imaging, warranting further animals studies for antitumor efficacy. These studies suggest that …
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Epiregulin as a Novel Target for Antibody-Drug Conjugate Development for the Treatment of Colorectal Cancer
… demonstrated minimal toxicity and significant antitumor efficacy in preclinical models of CRC. Future studies include further optimization of EREG-targeted ADCs or testing in combination with other therapies to ultimately eliminate tumors and prevent relapse.</p>
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Understanding and Targeting The Immunosuppressive Tumor Microenvironment
… and anti-CTLA-4, have shown impressive antitumor efficacy by improving the activity of T cells. While these inhibitors work in many patients with various cancer types, they have minimal or no effect in many more patients. Mounting evidence indicates that, besides current known immune …
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Overcoming the biological barriers to intravenous delivery of stem cells and drugs for the treatment of vascular-related diseases
… target destination. To maximize the therapeutic efficacy, this dissertation investigates the use of polymeric nanoparticles to improve the transport of intravenously administered therapeutics and their accumulation in the diseased sites. The first part of this dissertation focuses on the delivery …
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Poly(α-hydroxyalkanoic acid): Polymerization methodology, materials, and applications
… efficiency, well-tuned drug release and potent antitumor efficacy. In chapter 4, PAHAs with side chain modified tertiary amine groups was utilized as efficient gene delivery vehicle and high transfection efficiency was achieved. Finally, in chapter 5, we developed a caged metabolic precursor …
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The Mechanism of cGAMP Induced Antitumor Effect and Its Application in Treating Cancer and Antibody Generation
… the innate immune system, inducing strong antitumor responses. Direct cGAMP delivery into tumors has demonstrated significant antitumor effects in vivo. Despite this, knowledge gaps persist regarding immune cell types in the tumor microenvironment and their impact on tumor immune …
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Preclinical Evaluation of Immunomodulatory Effects of Aurora Kinase Inhibition In Human Papillomavirus Positive Cancers
… immunogenic cell death (ICD) that would promote antitumor efficacy of immune checkpoint therapy. The current investigation focused on the effectiveness of alisertib, an Aurora Kinase A inhibitor using preclinical mouse tumor models of HPV+ cancers (mEER, TC-1, and C3.43). In vitro, alisertib …
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Effects of Liposome-Encapsulated TNF-Alpha and Radiation against Colon Cancer
… tumor necrosis factor-α (TNF-α) can augment the antitumor effects of radiation, inhibiting tumor progression to a greater extent than either modality alone. However, nonspecific toxicities associated with TNF-α have limited its use as an adjuvant. This limitation is potentially resolved with the …
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Selective targeting of MYC by antisense oligonucleotides
… low potency, display poor selectivity, and lack antitumor efficacy, which has led MYC to be historically classified as 'undruggable.' Efforts aimed at indirectly targeting MYC transcription often lead to development of resistance characterized by reinforced expression of MYC. Clearly, alternate …
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Type-5 Phosphodiesterase Inhibition in the Prevention of Doxorubicin Cardiomyopathy
… demonstrated that sildenafil did not affect the antitumor efficacy of doxorubicin in PC-3 cells in vitro. In fact, flow cytometry data indicate that sildenafil, when combined with doxorubicin, was synergistic in the antineoplastic action of doxorubicin. Prophylactic treatment with sildenafil …
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DEVELOPMENT OF A NANOPARTICLE-BASED PLATFORM FOR THE DELIVERY OF THERANOSTIC AGENTS TO TUMOR TISSUE: TOWARD CLINICAL TRANSLATION
… concept for the encapsulation protocol and for efficacy studies in preclinical models, and innovative strategies for EV preservation were also developed. In particular, the EV formulation was applied to the following antineoplastic agents: i) doxorubicin, a classical broad-spectrum …
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Development of Nanomedicine to Simultaneously Target Pancreatic Cancer Cells and Stroma
… acts as a barrier that impedes the delivery of antitumor drugs into the tumor microenvironment and reduces the therapeutic efficacy. The objective of this dissertation is to develop combination therapies for pancreatic cancer by simultaneously targeting pancreatic cancer cells and the stroma. In …
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Engineering therapeutic proteins for immune modulation
… cytotoxicity (ADCC) is implicated in the efficacy, to some degree, of most anti-cancer monoclonal antibodies. This interaction is mediated through Fc gamma receptor (Fc[gamma]R) binding to the antibody Fc. Activating and inhibitory Fc[gamma]Rs are expressed on immune cells and bind to the …
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Targeting extracellular matrix using siRNA for the treatment of liver fibrosis and pancreatic cancer
… delivery efficiency, and therapeutic efficacy. Furthermore, we also developed and evaluated a feasible rat model for alcoholic liver fibrosis. In Chapter 1, we briefly introduced the background of the dissertation research and presented the Statement of the Problems and Objectives. In …
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