Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 248 for “"antitumor"”.
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Structures of the Didemnins (Antiviral, Antitumor, Compounds)
… (shown below), promising new antiviral and antitumor depsipeptides, have been isolated from a Caribbean tunicate. Their amino acid compositions were ascertained by gas chromatography/mass spectrometry of the trifluoroacetyl n-butyl ester derivatives of the amino acids present in the total …
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Immunostimulatory activity and antitumor efficacy of mSOT201 immunocytokine
… stimulation with mSOT201. Finally, we evaluated antitumor activity of mSOT201 in selected mouse tumor models. We showed that mSOT201 selectively and potently expanded activated CD8⁺ T cells while being nonstimulatory for naïve CD8⁺ and both activated and naïve CD4⁺ T cells in vitro. A single …
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Antitumor activity of antimalarials in human breast cancer cells
Previously we showed that quinidine arrested MCF-7 cells in G1 phase of the cell cycle and led to a G1 to G0 transition followed by apoptotic cell death (Wang et al., 1998). The present experiments demonstrate that MCF-7, MCF-7ras, T47D, MDA-MB-231, and MDA-MB-435 cells transiently differentiate …
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Anticarcinogenic, Antitumor, and Antifungal Properties of Allium Sativum (Garlic)
… immune enhancing, antitumor and antifungal effects of a crude extract and organosulfur compounds of garlic were determined. Diallyl sulfide (DAS), and ajoene each at 100 /xg/ml, and garlic extract (GE, 12.5 mg/ml) inhibited rat liver 9000 X g supernatant (S- 9) …
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Structural and Synthetic Studies of Potential Antitumor Natural Products
Bioassay directed fractionation of the methyl ethyl ketone extract of Chiloscyphus rivularis yielded eight sesquiterpenoids, and detailed spectroscopic interpretation led to the assignment of their structures as 12-hydroxychiloscyphone, chiloscypha-2,7-dione, 12-hydroxychiloscypha-2,7-dione, …
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Logic-gated activity sensors for programmable detection of antitumor immunity
… protease granzyme B (GzmB) can identify early antitumor responses induced by ICBT, and I apply a multiplexed library of sensors cleaved by immune- and tumor-associated proteases to classify mechanisms of resistance. As expression of proteases like GzmB and caspases is a conserved mechanism …
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Synthetic endeavours involving sparsomycin : the development of an antitumor antibiotic
Contains fulltext : mmubn000001_067725228.pdf (Publisher’s version ) (Open Access)
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Potential Mechanisms Explaining the Antitumor Effect of Total-Body Irradiation
… observed that moderate-dose TBI produces an antitumor effect in the Lewis lung carcinoma (EEC) model, the major goal of this study was to determine whether changes in tumor growth could be correlated with radiation-induced alterations of immune system parameters. The governing hypothesis was …
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Synthesis and mechanistic studies of novel antitumor transition metal complexes
In order to overcome side effects and drug resistance associated with conventional Pt(II) drugs, our lab has developed novel platinum complexes. One of the new platinum complexes developed in our lab is the monofunctional platinum anti-cancer compound phenanthriplatin. We have found that by binding …
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The antitumor activity of tumor-targeted RNA replicase-based plasmid DNA
… growth. The feasibility of further improving the antitumor activity of the RNA replicase-based plasmid by targeting it into tumors cells was also evaluated. An epidermal growth factor (EGF)-conjugated, PEGylated cationic liposome was developed to deliver the RNA replicase-based plasmid, pSIN-beta, …
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Importance of specific NK cell subsets for antitumor immunity in HPV+ cancers
… of care (SOC) treatment. Identifying the antitumor host immune mediators important for treatment response and designing strategies to promote them are essential for improving clinical outcome. The natural killer (NK) cells are a critical component for antitumor innate effector immunity. …
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The Role of TCR Engagement Strength in Antitumor CD8 T Cell Exhaustion
<p>Durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8 T cells (Tpex). Tpex serve as a source for the pool of effector T cells that tend to have a short lifespan or eventually become dysfunctional in uncleared tumors. In contrast to the …
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Primary photoprocesses of light-activated antiviral and antitumor agents, hypericin and hypocrellin
<p>The dissertation focuses on the ultrafast primary photoprocesses of the title anti-viral and anti-cancer agents, whose activity depends on light which is also accompanied by photoacidification in vesicles and living cells;By complementing the techniques of time-resolved absorption spectroscopy …
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The Antitumor Agent, Arglabin-DMA, Preferentially Induces Apoptosis in Human Colon Tumor Cells
… one or more non-Ras proteins to exert its antitumor effects. Gel electrophoresis, TUNEL assay, Annexin V assay, apoptosis dye-uptake assay, and morphological criteria were used to characterize apoptosis. Adherent cells and freely floating detached cells in Arglabin-DMA treatment were …
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NATURAL POLYPHENOLS AS LEAD COMPOUNDS IN THE SYNTHESIS OF ANTITUMOR AGENTS AND OTHER USEFUL PRODUCTS
… AS LEAD COMPOUNDS IN THE SYNTHESIS OF ANTITUMOR AGENTS AND OTHER USEFUL PRODUCTS Abstract Some polyphenol dimers, such as lignans, neolignans and stilbenoid lignans, because of their biological properties as well as their structural variety, are an attractive target for chemical …
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The selection of DNA damage targets in vivo and in vitro by enediyne antitumor antibiotics
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1998.
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The Mechanism of cGAMP Induced Antitumor Effect and Its Application in Treating Cancer and Antibody Generation
… the innate immune system, inducing strong antitumor responses. Direct cGAMP delivery into tumors has demonstrated significant antitumor effects in vivo. Despite this, knowledge gaps persist regarding immune cell types in the tumor microenvironment and their impact on tumor immune …
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