Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"antitubercular agents"”.
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Novel Antimalarial and Antitubercular Agents Based on Natural Products
… of the clinically used drugs in antimalarial and antitubercular chemotherapy are of natural product-origin. In this project we therefore focussed on the design, synthesis, characterization and biological evaluation of novel antimalarial and antitubercular agents obtained by synthetically …
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Developing methods to prioritize in vitro drug combinations against Mycobacterium tuberculosis: fusidic acid as potential combination partner with known antitubercular agents
… natural product antibiotic, and current anti-TB agents and, secondly, characterizing antibiotic action by delineating bacteriostatic and bactericidal compounds.
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Efflux-Mediated Multidrug Tolerance in Replicating Mycobacteria
… that they are no longer killed by currently used antitubercular drugs that target actively growing bacteria. The dormancy model of tolerance has been the center of antitubercular drug research with the pursuit of drugs to target bacterial determinants that are expressed in the nonreplicating phase …
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Aerosolizable Drug-Loaded SPIONs for Treatment and Diagnosis of Pulmonary Tuberculosis
… nanoparticles (SPIONs), capable of delivering antitubercular agents directly to the site of infection while providing T2-weighted magnetic resonance imaging (MRI) contrast for diagnostic tracking.SPIONs were synthesized via the chemical co-precipitation method and surface-stabilized with oleic …
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Elucidation of mechanisms of antibiotic subversion in mycobacteria
… "intrinsic resistome" that limit the efficacy of antitubercular agents. The DNA damage response: the SOS response was hypothesized to play a role in antibiotic- mediated cellular death, and that disabling the mycobacterial SOS response, by generating non-cleavable LexA mutants (lexA Ind-), could …