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Showing 1 to 7 of 7 for “"antitubercular agents"”.

  1. Novel Antimalarial and Antitubercular Agents Based on Natural Products

    … of the clinically used drugs in antimalarial and antitubercular chemotherapy are of natural product-origin. In this project we therefore focussed on the design, synthesis, characterization and biological evaluation of novel antimalarial and antitubercular agents obtained by synthetically …

    cape-town Repository record for Novel Antimalarial and Antitubercular Agents Based on Natural Products (opens in a new tab)

  2. Efflux-Mediated Multidrug Tolerance in Replicating Mycobacteria

    … that they are no longer killed by currently used antitubercular drugs that target actively growing bacteria. The dormancy model of tolerance has been the center of antitubercular drug research with the pursuit of drugs to target bacterial determinants that are expressed in the nonreplicating phase …

    washington Repository record for Efflux-Mediated Multidrug Tolerance in Replicating Mycobacteria (opens in a new tab)

  3. Aerosolizable Drug-Loaded SPIONs for Treatment and Diagnosis of Pulmonary Tuberculosis

    … nanoparticles (SPIONs), capable of delivering antitubercular agents directly to the site of infection while providing T2-weighted magnetic resonance imaging (MRI) contrast for diagnostic tracking.SPIONs were synthesized via the chemical co-precipitation method and surface-stabilized with oleic …

    creighton Repository record for Aerosolizable Drug-Loaded SPIONs for Treatment and Diagnosis of Pulmonary Tuberculosis (opens in a new tab)

  4. Elucidation of mechanisms of antibiotic subversion in mycobacteria

    … "intrinsic resistome" that limit the efficacy of antitubercular agents. The DNA damage response: the SOS response was hypothesized to play a role in antibiotic- mediated cellular death, and that disabling the mycobacterial SOS response, by generating non-cleavable LexA mutants (lexA Ind-), could …

    cape-town Repository record for Elucidation of mechanisms of antibiotic subversion in mycobacteria (opens in a new tab)