Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"antitrypsin"”.
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Characterization of Pleiotropic Activities of alpha1-Antitrypsin
… released from inflammatory cells. alpha1-antitrypsin (AAT), an acute phase protein, is the prototypic member of the serpin super family and a major inhibitor of serine proteases such as neutrophil elastase. The clinical importance of AAT is highlighted in individuals with inherited AAT …
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Oxidation of the sulfur-containing amino acids in recombinant human α1-antitrypsin
… methionine and cysteine in recombinant human xcl-antitrypsin, a metastable protein that is a member of the serpin family of plasma protease inhibitors. Analytical techniques were developed to identify and quantify oxidation of each of al-antitrypsin's ten methionine residues, as well as its …
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Exacerbations, health status and sibling pair comparisons in severe Alpha-1-Antitrypsin Deficiency
Alpha-1-Antitrypsin Deficiency (AATD) is a risk factor for the development of early-onset emphysema and airflow obstruction. The current work defines exacerbations, lung function and health status in these patients including sibling pairs. Exacerbations occur commonly in AATD and are associated …
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The role of genetic and environmental variation in the respiratory phenotype of alpha 1 antitrypsin deficiency
Alpha 1 antitrypsin deficiency (AATD) is the only established genetic predisposition to chronic obstructive pulmonary disease (COPD). The development of COPD in AATD is highly variable, probably relating to complex interactions between multiple genetic and environmental factors. This thesis will …
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Oxidative damage to recombinant proteins during production
… of an oxidatively-sensitive protein, a1-Antitrypsin, was investigated to ascertain the effect of fermentation parameters on the extent of oxidation. Oxidation of either of two methionine residues in the active site to methionine sulfoxide was sufficient for inactivation, and 50% of the …
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ΠΡΩΤΕΙΝΕΣ ΟΞΕΙΑΣ ΦΑΣΕΩΣ ΣΕ ΕΜΦΡΑΓΜΑΤΑ, ΕΓΧΕΙΡΗΣΕΙΣ ΚΑΙ ΛΟΙΜΩΞΕΙΣ
… REACTANT PROTEINS CRP HAPTOGLOBIN, A1 ANTITRYPSIN, A2 MACROGLOBULIN, AND A1 ACID GLYCOPROTEIN WERE STUDIED AFTER MYOCARDIAL INFARCTION, SURGERY AND VARIOUS INFECTIONS. IN SUMMARY CRP WAS CONSISTENTLY THE MST SENSITIVEOF FIVE ACUTE-PHASE REACTANT PROTEINS AND IS THEREFORE RECOMMENDED FOR …
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Monocyte adherence to fibronectin: role of CD11/CD18 integrins and relationship to other monocyte functions
… the physiological inhibitor of this enzyme (a1-antitrypsin). Maturation in vitro increased the accumulation of a1-antitrypsin by all of the monocyte subpopulations. In contrast, proinflammatory mediators up-regulated a1-antitrypsin accumulation by only the spontaneously adherent cells, probably …
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Alzheimer's disease and dementia with Lewy bodies: Special focus on the role of serpins
… serpins, namely alpha1-antichymyotrypsin, alpha1-antitrypsin and neuroserpin, in the context of AD and DLB. We have shown that alpha1-antichymotrypsin: (i) renders the oligomer formation profile of incubated Abeta1-42, favouring dimer formation; (ii) under certain conditions appears to protect …
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The effect of dissolved oxygen on recombinant protein degradation in Escherichia coli
… on the degradation of recombinant [alpha]1-antitrypsin ([alpha]1AT) during production in E. coli. a 1-antitrypsin degradation increases with dissolved oxygen concentration, with -20% degraded under anaerobic conditions and approximately -50% degraded in cultures sparged with pure oxygen. …
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An integrated process for the recovery of clinically significant trace proteins from human plasma
… important proteins such as transferrin, alpha-1-antitrypsin and platelet-derived growth factor was considered. A high-purity factor VIII concentrate heat-treated at 80°C for 96 h was prepared by a process that incorporated heparin fractionation. This method was shown to be suitable for …
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Serpin polymers enforce molecular filtration in the endoplasmic reticulum
… of which can be toxic and cause disease. Alpha1-antitrypsin is the serine protease inhibitor (serpin) that is secreted mainly by hepatocytes and acts in lungs where its major function is to inhibit neutrophil elastase. Neuroserpin is a serine protease inhibitor expressed in the nervous system. …
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Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… C3, pre-albumin, α1-acid glycoprotein, α1-antitrypsin, PEDF, CC4, ICAM-1, RANTES, clusterin, and cystatin c. We recruited 61 participants (placebo = 31; lithium = 30). The age baseline mean was 40 (±8.35) years and the median CD4+ T-cell count was 498 (IQR: 389 – 651) cells/μL. Biomarker …
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Prognostic role of tumour associated trypsin inhibitor in colorectal cancer patients
… trypsin inhibitor (TATI) is a form of antitrypsin, a 6kDa enzyme that inhibits trypsin with great affinity and TATI has previously been found to be of prognostic importance in mucinous ovarian cancer and other cancer forms. TATI is expressed in normal colonic mucosa, where its main …
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Chronic hepatitis at Groote Schuur Hospital: 1978-1996 : a literature review of the syndrome, its clinical spectrum and management at Groote Schuur Hospital
… Primary sclerosing cholangitis, alpha-1-antitrypsin deficiency, alcohol abuse and iron over load states.
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Rice bran supplementation modulates environmental enteric dysfunction markers and serum metabolites in weaning Nicaraguan infants
… and inflammation in the stool marker Alpha-1-Antitrypsin (p=0.02) and beneficial effects on gut function in the serum Glucagon-like-peptide-2 (p<0.04). Fifty-four serum metabolites were significantly different following RB supplementations versus control. These results support multiple …
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Candidate genes other than the CFTR gene as possible modifiers of pulmonary disease severity in cystic fibrosis
… risk allele: 1) antiprotease gene alpha-1-antitrypsin (alpha-1-AT), 2) innate immunity genes: mannose binding lectin (MBL2) (promoter [G→C] at -221 and codon 52 (Arg52Cys, D allele), 54 (Gly54Asp, B allele), and 57 (Gly57Glu, C allele), and pulmonary surfactant genes SPA-1 (Arg219Trp), …
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Novel risk factors for atrial fibrillation in an urban population
… fibrinogen, haptoglobin, orosomucoid and α1-antitrypsin) were significantly associated with incidence of AF. Plasma levels of ceruloplasmin were associated with incidence of AF. Genetic polymorphisms in the promoter of the ceruloplasmin gene were associated with elevated plasma levels of …
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Bronchoalveoläre Lavage bei Kindern mit malignen Erkrankungen, Immunsuppression, Fieber und Lungeninfiltraten
… wurden beobachtet: Bei den Patienten war das a1-Antitrypsin vermehrt, der Anteil an Ig-bindendem Faktor, Transthyretin und Cystatin S schien jedoch vermindert zu sein. Im Bereich der kleinen sauren Proteine behinderte der relativ hohe Anteil an Immunglobulinketten die Separation und …
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