Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"antithrombotic"”.
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Antithrombotic agents under flow conditions
… inhibition by two distinct classes of antithrombotic agents: anti-platelet antibodies and anticoagulants, including unfractionated heparin (UFH), low molecular weight heparin (LMWH) and hirudin. <br></br><br></br>Increasing flow rates increased TG, which was higher in the presence of …
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Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene
This study describes the preparation and physicochemical characterization of inclusion complexes formed between selected cyclodextrins (CDs) and ajoene, an antlthrombotlc found in garlic. The E and Z isomers of ajoene (4,5,9,-trithiadodeca-1,6,11-triene-9-oxide) were reacted with α, β, γ-CD …
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Antithrombotic and anti-inflammatory activity of ethyl acetate extract of Protorhus longifolia stem bark
… Despite great efforts made in the discovery of antithrombotic agents, ischemic events continue to claim more lives. Thus, there is a need to discover and develop new and more effective antithrombotic drugs, preferably from natural sources. The study is aimed at investigating the anti-thrombotic …
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UNDERSTANDING GENERALIZED ALLOSTERY IN THROMBIN
… a critical drug target for chemotherapeutic and antithrombotic therapy development. Although many experiments have demonstrated that thrombin is a multifunctional allosteric enzyme, the exact mechanism of thrombin's allostery is still unclear and widely debated. This dissertation describes my …
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Synthesis of pinane thromboxane A₂ via suzuki-miyaura coupling
… analog of the unstable thromboxane A₂ [2]. Its antithrombotic activity includes the inhibition of platelet aggregation, artery constriction, and thromboxane synthetase [2] and the contraction of induced stomach muscle [3].</p> <p>This project focuses on the synthesis of pinane thromboxane A₂ via …
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Endovascular Optical Coherence Tomography Imaging in Cerebrovascular Disease
… and residual thrombus. OCT may guide future antithrombotic treatment for patients with demonstrated residual thrombus. OCT carries great promise in the future of neurointerventional surgery.
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Feasibility and Acceptability of a SystemCHANGE™ Intervention to Improve Medication Adherence in Older Adult Stroke Survivors: A Pilot Randomized Controlled Trial
… 2-month SystemCHANGE™ intervention to enhance antithrombotic medication adherence (MA) in 30 older non-adherent stroke survivors recruited from a Midwestern neurology office using an RCT design with an attention-control group. SystemCHANGE™, grounded in the socio-ecological model, sought to …
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Platelet Receptor Glycoprotein VI in Ischaemic Stroke
… of GPVI-dimer could be a promising future antithrombotic target.
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Coaxially electrospun heparin-eluting scaffolds for vascular graft application
… post-TBA-modification, did not fully retain its antithrombotic properties (54.9 % reduction), which was further reduced after incorporation and release (24.2 % reduction). HepNa+ , however, retained its full antithrombotic activity post coaxial incorporation and elution. Coaxial electrospinning …
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Enhancing the Use of Network Meta-analysis to Synthesize Information on Benefits and Harms of Drugs to Support Regulatory and Reimbursement Decisions in Canada
… documents to populate a network meta-analysis of antithrombotic therapies for atrial fibrillation. In Chapter 3, the advantages and disadvantages of rapid network meta-analysis using ClinicalTrials.gov are investigated by re-doing Chapter 3 but only using data available in ClinicalTrials.gov and …
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Compositional Determinants of the Pharmacological Actions of Heparins
… a higher anti-FXa/FIIa ratio, promotes a better antithrombotic and safety profile compared to non-enriched heparin derivatives. Overall, this dissertation provides a comprehensive biochemical and pharmacological investigation in which not only the molecular weight dependence, but also the …
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ACUTE ISCHEMIC STROKE: CANCER-RELATED STROKE AND MULTIMODAL ANALYSIS OF THROMBI.
… collaborations, focusing on outcomes, antithrombotic and anticancer strategies, and the role of newly diagnosed vs known cancer. In parallel, we created the POLIclinico-Stroke-Thrombi-Analysis-Registry (POLISTAR) to prospectively collect thrombi with linked clinical, imaging, …
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The evaluation of novel nanoporous materials for use in interventional cardiology
… of direct NO release from MOFs holds promise for antithrombotic interventions. This research provides valuable insights into the potential of NO-releasing MOF/polymer materials for use in medical devices. The material 5 wt% Zn CPO-27 MOF incorporated in the PEBAX 5533 polymer is identified as a …
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A Microfluidic Approach For Investigating Thrombosis And Hemostasis: From Disease Models To Drug Testing
… also displayed heightened sensitivity to antithrombotic drugs. The majority of the patients who underwent surgical operations had increased platelet deposition 24 hours after surgery whereas the trend for fibrin polymerization was less clear. The significant increase in platelet response …
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Exploring the therapeutic potential of the apelin receptor signalling axis, and angiotensin-converting enzyme 2 (ACE2) as the SARS-CoV-2 viral entry receptor, in the cardiovascular system
… disorders, where the receptor also mediates antithrombotic responses. Here, four novel fluorescent ligands, designed as functional analogues of endogenous apelin and ELA peptides, were validated and used as a versatile tool for the qualitative and quantitative determination of pharmacological …
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In vitro and in vivo studies on the activating platelet collagen receptor glycoprotein VI in mice
… was performed to evaluate its potential as an antithrombotic target. The first mAb against (mouse) GPVI, JAQ1, was generated and used to demonstrate that GPVI requires the FcRgamma-chain for its expression and function and that this receptor is the central molecule in collagen-induced platelet …
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Nanoparticle systems that exploit host biology for diagnosis and treatment of disease
… increase in bleeding, the primary side-effect of antithrombotic therapy in the clinic. Finally, we investigated a two-component system whereby the first therapeutic entity induces the upregulation a molecular signal within a malignant environment to amplify the local recruitment of a secondary …
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Mechanische Thromboseprophylaxe bei Hüft-Endoprothesen : prospektive Studie zum Einsatz des Venaflow-Gerätes
… molecular weight heparin (LMWH; Fragmin), wore antithrombotic stockings and were mobilised the first day after operation. After theatre n=39 patients received the Venaflow for 3 days, further n=57 patients were followed up in the control- group. Every day during the doctor's round clinical signs …
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Targeting phosphatidylserine exposure in pro-coagulant platelets.
… in pro-coagulant platelets could be a novel antithrombotic strategy.
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Is the door closed? : In vitro studies on the pharmacokinetic effects of OATP1B1 gene-drug and drug-drug interactions.
… was also investigated. Ticagrelor (an antithrombotic drug) and rosuvastatin (a cholesterol-lowering drug) are both commonly prescribed as secondary prevention after cardiovascular events. The in vitro inhibition assays using the same expression method and ticagrelor and rosuvastatin …
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