Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"antisense inhibition"”.
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Functional analyses of tomato 3-hydroxy-3-methylglutaryl coenzyme a reductase (HMGR) genes in transgenic plants engineered for altered HMGR expression
… gene fusions, overexpression of hmg2 cDNA, and antisense inhibition of hmg1 and hmg2 in transgenic plants. Activity of the hmg2 promoter is developmentally regulated showing expression in seedling cotyledons and hypocotyls, in trichomes, and in reproductive tissues including pollen, stigmas, …
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Investigating novel treatment approaches to combat Clostridioides difficile
… called peptide nucleic acids (PNAs). PNAs are antisense agents capable of inhibiting gene expression in bacteria. In this study, antisense inhibition of the RNA polymerase subunit gene (rpoA) of C. difficile was found to be bactericidal for the pathogen and could also inhibit the expression …
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Trypanosoma Cruzi Phosphoinositide -Specific Phospholipase C (tcpi-Plc) and Its Role in Differentiation
… is involved in this differentiation step, antisense inhibition using phosphorothioate-modified oligonucleotides, and overexpression of the gene were performed. Antisense oligonucleotide-treated parasites showed a reduced rate of differentiation in comparison to controls, as well as …
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Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… of FGF19 metabolic target genes. In vivo antisense inhibition of miR-34a in obese mice partially restored βKL levels and improved FGF19 target gene expression and resulted in beneficial metabolic outcomes such as weight loss and increased insulin sensitivity establishing the important role …