Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 470 for “"antiretroviral therapy"”.
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Adherence to highly active antiretroviral therapy among patients in the Keetmanshoop antiretroviral therapy programme, Namibia
… HIV patients in the public health sector. The antiretroviral treatment programme in Keetmanshoop started in October 2003. Adherence to treatment regimes in HIV care is a key factor in determining clinical outcomes and is associated with improved survival among HIV and AIDS patients. Sustained …
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Adherence to paediatric antiretroviral therapy in South Africa
… der HIV-infizierten Kinder, die in Südafrika mit antiretroviralen Medikamenten behandelt werden, steigt drastisch. Das korrekte Befolgen der Therapie (die sogenannte Adhärenz) ist ein Schlüsselfaktor für deren Erfolg. Diese Studie untersuchte die Adhärenz von jungen ambulanten Patienten und führte …
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The impact of antiretroviral therapy on tuberculosis incidence
Introduction Although HIV infection increases the likelihood of developing TB, evidence suggests that starting ART reduces the risk of TB incidence although not to the level of HIV negative people in the population. This study aims to determine the impact of ART on TB incidence in people living …
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Evolution of sensory neuropathy after initiation of antiretroviral therapy
… the evolution of sensory neuropathy after antiretroviral therapy (ART) in human immunodeficiency virus–infected South Africans. Methods: Enrolment commenced before ART with 6-monthly follow-ups for 24 months. Symptomatic distal sensory polyneuropathy (SDSP) was defined as one symptom and …
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Outcomes of infants starting Antiretroviral therapy in Southern Africa
Within the global burden of the Human Immune Deficiency Virus (HIV) stands a distinct group - HIV infected infants. They are a physically, physiologically, developmentally and socially vulnerable group who differ considerably from their adult and child HIV infected counterparts. Distinguished in …
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HIV-1 protease as a target for antiretroviral therapy
Human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency syndrome (AIDS). HIV employs three enzymes in its lifecycle, including a protease that enables maturation of polyprotein precursors. Despite decades of progress studying the lifecycle of HIV and elaboration of …
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HIV, Antiretroviral Therapy, Pregnancy, Lactation and Bone Health in Uganda
… World Health Organisation recommends lifelong antiretroviral therapy (ART) for all HIV+ pregnant and breastfeeding mothers to prevent MTCT, and breastfeeding for ≥24 months for optimal child health in resource limited settings (Option B+ strategy). Initiation of ART in HIV+ adults is associated …
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Chronic morbidities in perinatally HIV-acquired adolescents on antiretroviral therapy
… on ART were enrolled in the Cape Town Adolescent Antiretroviral Cohort (CTAAC) from seven health-care sites in Cape Town, South Africa, between July 2013 – April 2015. Eligibility criteria were adolescents, 9-14 years old, with perinatally acquired HIV, been on ART for at least six months, and who …
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Evaluation of adherence to antiretroviral therapy using efarivenz as a marker
Background: Patients on antiretroviral (ART) are expected to be at least 95% adherent to their treatment, as this will increase their chances of achieving treatment success (maximum and durable suppression of HIV-1 viral load); non-adherence may lead to the development of HIV drug resistance, which …
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A Transferrin conjugated nanoemulsion system for brain delivery of antiretroviral therapy
… is challenging to treat because most of the antiretroviral therapeutic (ART) agents cannot achieve the desired therapeutic levels in the central nervous system (CNS) because they cannot efficiently cross the blood-brain barrier (BBB). The goal of this study is to develop a new transferrin …
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The evolution and effectiveness of the South African antiretroviral therapy program
Although South Africa has the largest antiretroviral therapy (ART) program worldwide, data on key outcomes like mortality and loss to follow-up (LTF) are limited. A few cohorts have published patient outcomes but there is no national reporting on ART scale-up and its impact on the health of …
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Restoration of cellular immunity in HIV-infected individuals on antiretroviral therapy
… Whilst the widespread implementation of antiretroviral therapy (ART) has led to reduced morbidity and mortality in most HIV-infected individuals having access to treatment, we still do not know whether full restoration of immune function occurs. The aim of this study was to assess the …
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HIV-associated neurocognitive disorders biomarkers and the response to antiretroviral therapy
… study aimed to determine whether highly active antiretroviral therapy (HAART) improved cognitive function in HIV positive people in South Africa, and whether this effect differed according to the CNS penetration-effectiveness (CPE) of the regimen used. I also investigated potential …
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Cardiometabolic Diseases and HIV Infection: The Impact of Highly Active Antiretroviral Therapy
… of these outcomes with exposure to highly active antiretroviral therapy (HAART) medications i.e. protease inhibitors (PIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). </p> <p> Methods: The study population included …
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Community-led study of access to antiretroviral therapy and viral load testing.
Access to antiretroviral therapy (ART) has expanded in sub-Saharan Africa, yet sustained retention and viral-load testing remain fragile. In Ghana, sexual and gender minority (SGM) populations including men who have sex with men (MSM) and transgender women (TGW) experience intersecting …
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Outcomes and cost-effectiveness of different models of delivery of antiretroviral therapy
Background: HIV remains a major contributor to the burden of disease in the Eastern and Southern African region, where around half of those with HIV/AIDS reside, according to the 2016 UNAIDS estimates. Data on the direct costs and outcomes of providing health care are important due to competing …
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Factors influencing adherence to Antiretroviral Therapy at a General Hospital in Mombasa, Kenya
… 000 new infections in 2008. The introduction of antiretroviral therapy [ART] brought new hope to HIV patients. It has transformed a fatal disease to a chronic manageable condition. Kenya has made great strides in ensuring access to ART and by 2009, 308 610 patients in the country were receiving …
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The enduring challenges of antiretroviral therapy. Focus on drug-related neurotoxicity and inflammation
Contains fulltext : 236306.pdf (Publisher’s version ) (Open Access)
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Auswirkungen und Veränderungen bei HIV-assoziierten Hauterkrankungen durch HAART (Highly Active Antiretroviral Therapy)
… skin diseases under HAART (highly active antiretroviral therapy) Introduction: The spectrum of skin diseases in HIV-infected patients is wide, with cutaneous infections being most common. The introduction of highly active antiretroviral therapy [HAART], especially in combination with …
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Metabolic complications resulting from the use of antiretroviral therapy in HIV-infected patients
While antiretroviral therapy (ART) has extended the life expectancy of those infected with HIV, it is also associated with a number of metabolic complications, such as dysglycaemia, insulin resistance and lipodystrophy. Lipodystrophy is characterised by an increase in trunk fat (lipohypertrophy) …
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