Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"antipsychotic drugs"”.
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Discriminative Stimulus Effects of Putative Antipsychotic Drugs
… the discriminative stimulus properties of antipsychotic drugs, by establishing the typical antipsychotic drug chlorpromazine, and the atypical antipsychotic drug clozapine as discriminative stimulus in two different groups of rats. The rats trained to discriminate chlorpromazine from …
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Antipsychotic drugs for the treatment of acute schizophrenia after the first episode
Background: Antipsychotic drugs (APDs) represent the treatment of choice for psychotic disorders, but uncertainty surrounds the optimal selection of agents. Methodology: This was a mixed method study which included a systematic review and psychiatrists’ opinion survey. The systematic review focused …
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The impact of antipsychotic drugs on the expression of genes associated with obesity
… debilitating disorder, primarily treated with antipsychotic medication. Weight gain is a serious side-effect associated with most second generation antipsychotic drugs such as clozapine. The mechanism behind clozapine-induced weight gain remains poorly understood, but changes in eating …
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METABOLIC ADVERSE EFFECTS INDUCED BY SECOND GENERATION ANTIPSYCHOTIC DRUGS IN PEDIATRIC PATIENTS: PHARMACOGENETIC PROFILING AND MECHANISTIC ANALYSIS OF GENETIC VARIANTS EFFECT IN VITRO MODELS
Second-generation antipsychotics (SGAs) are increasingly used in pediatric patients both in and offlabel. The rise in SGA prescription rates may be due to the perception of improved safety compared with first-generation antipsychotics. However, SGA use is often associated with rapid weight gain and …
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The Discriminative Stimulus Properties of the Atypical Antipsychotic Clozapine in C57BL/6 Mice
… receptor antagonism may contribute to atypical antipsychotic drug effects. Clozapine (2.5 mg/kg) drug discrimination in C57BL/6 mice may selectively screen atypical antipsychotic drugs. Previous data show that the atypical antipsychotics olanzapine, risperidone, ziprasidone but not the typical …
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Dopamine D1-Like, D2 and D3 Receptor Subtypes in Catalepsy Sensitization and Conditioning in Rats: Implications for Motor Function, Motivation and Learning
The behavioral effects of drugs that act on the brain’s dopamine (DA) system change with repeated exposure to the drug. Antipsychotic drugs, that block DA receptors, produce progressively greater effects on behavior with repeated testing. For example, rats repeatedly treated with a low dose of the …
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EFFECTS OF OPTOGENETIC ACTIVATION AND PHARMACOLOGICAL MODULATION OF DOPAMINE NEURONS
… drug and dopamine releaser. Conversely, antipsychotic drugs may reduce positive symptoms by blocking dopamine receptors. This study used optogenetics to explore how drugs that alter neurotransmission, might alter behaviors occurring from activation of mesolimbic dopamine (DA) neurons in …
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Effects of repetitive transcranial magnetic stimulation as a treatment for persistent auditory verbal hallucinations
… of stress and functional debility. Atypical antipsychotic drugs are the recommended treatment for AVHs but are non-effective in 25-30% of cases. Cognitive behavioral therapy (CBT) has proven reasonably effective but improvements can still be made to the treatment for some patients that …
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Documentation: Delirium in the Hospitalized Older Adult
… frequently addressed by administering dangerous antipsychotic drugs, it is imperative that accurate systematic assessments are charted to determine the actual need for these medications. The purpose of the study was to describe medical record documentation of a systematic assessment of delirium …
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Investigating the Immunological Effect of Schizophrenia-Related Antigens and Anti-psychotic Medication.
… the initial findings were thus replicated in antipsychotic-naïve patients with first-episode schizophrenia from a Chinese population. The drug-naïve patients showed different results; notably, the significant decrease in plasma IgG levels against TSNARE1 was not observed, showing instead an …
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Investigation of Psychotropic Drugs for the Treatment of Glioblastoma
… with temozolomide, one of the few approved drugs for the treatment of glioblastoma. Unfortunately, most tumours develop resistance against temozolomide and therefore, new treatment modalities are urgently required. Meta-analysis of cancer in schizophrenic patients suggests a lower incidence …
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FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS
… and schizophrenia. First and second generation antipsychotic drugs antagonize dopamine D2 receptor. Notably, both these classes of drugs may cause side effects associated with D2 receptor antagonism (e.g. hyperprolactemia and extrapyramidal symptoms). The novel, “third generation” antipsychotic …
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The gut microbiota as a contributing factor to antipsychotic-induced weight gain and metabolic dysfunction
… recent decades with the discovery of several antipsychotic compounds; however these drugs are not without adverse effects that must be addressed to maximize their therapeutic value. Newer, atypical, antipsychotics are associated with a compilation of serious metabolic side effects including …
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Studies into Amphetamine-Induced Unconditioned Behaviour in the Rat.
… function. These models have been used to study drugs which are effective in the treatment of schizophrenia. Only locomotion is reliably antagonised by all classes of antipsychotic drugs, although it has been hypothesised that, under some doses of amphetamine, locomotion may also become …
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The Role of Vitamin D and Antipsychotic Drug-induced Weight Gain
… Pharmacotherapy in the form of second generation antipsychotic drugs (SGAs), including quetiapine, is the primary treatment for schizophrenia; however, the growth in utilization of these medications has led to a simultaneous rise in the occurrence of weight gain and metabolic syndrome in this …
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Signal transduction by the 5-HT2A receptor and its H452Y polymorphic variant
… the actions of a number of hallucinogenic and antipsychotic drugs. Additionally, certain polymorphic variants of the receptor, such as an allele resulting in substitution of amino acid 452 histidine (H) with tyrosine (Y), have been linked to schizophrenia or altered therapeutic response to …
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Mechanism of Action of Antipsychotics, Haloperidol and Olanzapine in vitro
… Haloperidol (HP), a butyrophenone and a typical antipsychotic, has been used as an antipsychotic drug in human. Unfortunately, the therapeutic effects of HP also come with severe extrapyramidal side effects, resulting in movement disorders in patients. Olanzapine, a new atypical neuroleptic, …
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Long-range synchrony between medial prefrontal cortex, thalamus and hippocampus underlies working memory behavior in mice.
Presently, there are no antipsychotic drugs capable of treating the cognitive dysfunctions of schizophrenia. In order to inform the development of better therapies, it is essential to understand the mechanism behind dysfunctional cognition, which requires an understanding of functional cognition. …
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Understanding the impacts of antipsychotic pharmaceuticals on behaviour in fish
… neuroactive pharmaceuticals, and particularly antipsychotic drugs (APDs), represent an emerging environmental concern due to their pseudo-presence, bioaccumulative potential and potency in modulating central nervous system (CNS) targets. APDs act on evolutionarily conserved monoaminergic, …
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