Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"antipsychotic drug"”.
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The Role of Vitamin D and Antipsychotic Drug-induced Weight Gain
… Pharmacotherapy in the form of second generation antipsychotic drugs (SGAs), including quetiapine, is the primary treatment for schizophrenia; however, the growth in utilization of these medications has led to a simultaneous rise in the occurrence of weight gain and metabolic syndrome in this …
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Concurrent Stimulant and Atypical Antipsychotic Drug Use in Children and Adolescents Diagnosed with Attention Deficit/Hyperactivity Disorder (ADHD)
Background: Multiple psychotropic drug use is highly prevalent in children and adolescents despite the lack of sufficient safety and efficacy data for such use. Few studies evaluated the concurrent use of stimulant and atypical antipsychotic agents in children and adolescents diagnosed with …
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Discriminative Stimulus Effects of Putative Antipsychotic Drugs
… the discriminative stimulus properties of antipsychotic drugs, by establishing the typical antipsychotic drug chlorpromazine, and the atypical antipsychotic drug clozapine as discriminative stimulus in two different groups of rats. The rats trained to discriminate chlorpromazine from …
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The Discriminative Stimulus Properties of the Atypical Antipsychotic Clozapine in C57BL/6 Mice
… receptor antagonism may contribute to atypical antipsychotic drug effects. Clozapine (2.5 mg/kg) drug discrimination in C57BL/6 mice may selectively screen atypical antipsychotic drugs. Previous data show that the atypical antipsychotics olanzapine, risperidone, ziprasidone but not the typical …
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Modular Approaches for the Synthesis of α-Azinyl Amines and Related Scaffolds
… alcohols, including an aza analogue of an antipsychotic drug haloperidol. To further demonstrate its synthetic utility, the carbonyl azinylative amination reaction was leveraged to enable the synthesis of nitrogen-rich and pharmaceutically-relevant α-azinyl piperidines. Proposed future work …
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Effects of Penfluridol On Integrin-Fak Signaling and Tumor Cell Killing In Combination With Oncolytic Hsv In Glioblastoma
… we investigated the use of Penfluridol, an antipsychotic drug known to attenuate integrin expression at a transcriptional level, in combination with oncolytic herpes simplex I virus (oHSV) in a glioblastoma model. We examined the effects of oHSV on FAK signaling by looking at FAK …
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FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS
G protein-coupled receptors (GPCRs) are drug targets that often activate multiple signaling pathways. The multiple GPCR responses provide opportunities for biased or functionally selective ligands to preferentially modulate one signaling pathway over another. Studies with several GPCRs have …
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Pharmacological Intervention Reduces Hippocampal Hyperactivity in a Mouse Model of Psychosis
… and it could become a candidate for testing antipsychotic drug activity. The subchronic DG inhibition causes a lasting downstream hippocampal hyperactivity, along with behavioral consequences. This doctoral dissertation examines the influence of antipsychotic and experimental compounds on …
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The involvement of microglial activation in schizophrenia
… cell line to serum isolated from first-onset drug-naïve schizophrenia patients (n=60) and healthy controls (n=79). We were able to show that peripheral blood serum obtained from schizophrenia patients induced differential microglial cell signalling network responses in vitro. We subsequently …
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Mechanism of Action of Antipsychotics, Haloperidol and Olanzapine in vitro
… Haloperidol (HP), a butyrophenone and a typical antipsychotic, has been used as an antipsychotic drug in human. Unfortunately, the therapeutic effects of HP also come with severe extrapyramidal side effects, resulting in movement disorders in patients. Olanzapine, a new atypical neuroleptic, …
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Using Multimodal MRI Techniques to Understand the Role of Hippocampus in Schizophrenia
… both with (SZ-on) and without (SZ-off) antipsychotic drug treatment. Single-voxel localized scalar (J) difference editing sequence was used in 1H MRS to measure glutamate (Glu), GABA and N-acetylaspartate (NAA) concentrations in the left hippocampus in normal control (NC), SZ-on and …