Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"antiproliferative activity"”.
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Synthesis and Antiproliferative Activity of C3' and B-ring Modified Paclitaxel Analogs
The natural product, paclitaxel, has made tremendous contributions in supplying the arsenal of anticancer therapeutics, and was FDA approved for clinical use in 1992. In order to design simplified analogs, the conformation that paclitaxel adopts when binding to tubulin has been the subject of …
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Antiproliferative Activity of Carotenoids, Phenolic Compounds, and Volatile Terpenoids in Carrots (Daucus carota L.)
… objective of this study was to compare the antiproliferative effects of carotenoids, phenolics, and volatile terpenoids extracted from carrots on Caco-2 colon cancer cells in vitro. Briefly, carrot carotenoids, phenolics, and volatiles were extracted from carrots using liquid-liquid, solid …
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Isolation and characterisation of novel glycosaminoglycan-like polysaccharides derived from marine molluscs with antiproliferative activity
… and targeted therapy, newly developed drugs with antiproliferative/cytotoxic effects are still in demand; hence, newly discovered anticancer drugs with an improved pharmacological profile are needed to overcome drug resistance of cancer cells. This study focused on identifying and characterising …
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Structural Characterization and <em>in vitro</em> Antiproliferative Activity of Non-Specific Lipid Transfer Protein 1 (nsLTP1) from Fennel (<em>Foeniculum vulgare</em>) Seeds
… 3D structure modeling, and <em>in vitro </em>antiproliferative activity of nsLTP1 from fennel (<em>Foeniculum vulgare</em>) seeds.</p> <p>Fennel<em> </em>is a member of the family Umbelliferae (Apiaceae) native to southern Europe and the Mediterranean region. It is used as a spice, medicine …
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Isolation, Structure Elucidation, and Total Synthesis of Biologically Active Natural Products from Plants
… extracts were investigated for antiplasmodial activity, thirteen plant extracts were investigated for antiproliferative activity, and one extract was investigated for inhibitors of the shikimate pathway in Plasmodium falciparum. Bioassay-guided fractionation of the extracts led to the …
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Investigations of the health benefits of buttermilk fat globule membrane lipid components
… of MFGM, potentially influencing its anticancer activity. The aim of this project was to determine if anticancer activity can be attributed to sweet and fermented buttermilks which contain fragments of MFGM and examine if different milk processing operations (separation, washing, heating and …
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Development of new bioorganometallic metallodendrimers as in vitro anticancer agents
… dendritic scaffold, and investigate the in vitro antiproliferative activity of these complexes.
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Cytotoxic Activity of Non-Specific Lipid Transfer Protein (nsLTP1) and Proteomic Evaluation of Heparin-Binding Proteins from Ajwain (Trachyspermum ammi) Seeds
… molecule extracts, leaving the protein’s bioactivity undiscovered. The present study demonstrated the antiproliferative activity of ajwain nsLTP1 in MCF-7, AsPC-1, and MCF10A cell lines and its structural stability in human serum and high-temperature conditions. The antiproliferative activity …
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Translational development and mechanistic insights into 3-(4- hydroxyphenyl)indoline-2-ones as a potent class of breast cancer therapeutics
… of compounds that exhibited potent biological activity for decades, but little was known regarding the mechanism of action. Oxyphenisatin acetate, a founding member of this class, was used as a laxative in the 1960’s, and in subsequent decades was found to have antiproliferative activity …
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Isolation and Synthesis of Bioactive Compounds from Plants
… plant extracts were investigated for their antiproliferative activity against the A2780 cell line, three plant extracts were investigated for their antimalarial activity against Plasmodium falciparum, and three plant extracts were investigated for their anti-inflammatory activity (PPAR-y …
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Isolation and Structure Elucidation of Antiproliferative Agents From Madagascar Rainforests
… All four compounds exhibited good antiproliferative activity on the A2780 bioassay. The fractionation of the extract of Grewia sp. led to the isolation of one new and one known triterpenoid. The known triterpenoid was identified as 7β-hydroxy-23-deoxojessic acid and its structure …
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Discovery of Novel Tubulin Inhibitors and Selective Survivin Inhibitors for Advanced Melanoma and Total Synthesis of Bioactive 20S-hydroxyvitamin D3
… treating advanced melanoma. Extensive structure-activity relationship (SAR) studies of lead molecules ABI-231 and UC-112 have been performed.</p> <p>Chapter 1 will introduce the current situation of advanced or metastatic melanoma, its clinical drug treatments, as well as problems in current drug …
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Antiproliferative Natural Products from the Madagascar Rainforest
… were selected for investigation based on their antiproliferative activity. Bioassay-guided fractionation of five of the extracts yielded sixteen new compounds, and their structures were determined using a combination of 1D and 2D NMR experiments, including COSY, HSQC/HMQC, HMBC, and ROESY/NOESY …
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SYNTHESIS AND CHARACTERIZATION OF RESVERATROL AND ITS CONJUGATED METABOLITES AND CONTRIBUTION OF METABOLISM TO ITS DECREASED BIOVAILABILITY
… that resveratrol metabolites possess intrinsic activity and thus contribute to the observed effects of the parent. The mono-sulfated and glucuronidated conjugates of trans-resveratrol were synthesized and tested for antiproliferative activity in a panel of mammalian cell lines. Their activity …
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Structure-Activity Relationship and Mitochondrial Actions of Ionic Liquids as Potential Anticancer Agents
… For these reasons, a well-defined structure-activity relationship (SAR) describing IL anticancer activity is important, however the current SAR is limited due in part to the low structural diversity of reported ILs. One of the aims of this project was to expand the SAR of ILs by assessing the …
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Searching for Anticancer Agents and Antimalarial Agents from Madagascar
… Group (ICBG) program, a total of four antiproliferative extracts were studied, leading to the isolation of twelve novel compounds with antiproliferative activity against the A2780 human ovarian cancer line, and one extract with antimalarial activities was studied, which led to the …
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Isolation and Structure Elucidation of Anticancer and Antimalarial Natural Products
… plant extracts were investigated for their antiproliferative and antimalarial activities. Bioassay guided fractionation of thirteen extracts led to the identification of three new antiproliferative compounds, ethyl leptaulosides A-C (5.1-5.3), six new antiplasmodial compounds, …
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Synthesis, radiolabelling and pharmacological evaluation of CO-releasing molecules
… a model using the myoglobin assay. The in vitro antiproliferative activity of the Re(I) complexes was investigated against three cancerous cell lines (A431, DLD-1 and A2780) and one non-tumourigenic cell line (BJ). The complexes displayed moderate to good activity, with all IC50 values in the low …
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Identification and characterisation of a novel antimicrobial peptide from the defensive skin secretion of the Heilongjiang brown frog, Rana amurensis
… have important effects on the antimicrobial activity of the peptide. So, an increasing number of researchers have begun to pay attention to the relationship of structure and activity of peptides. The amphibian skin secretion is a huge resource for AMPs. In this study, a novel AMP (QUB-2944) …
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Identification and bio-evaluation of an antimicrobial peptide from the skin secretion of Phyllomedusa tarsius
… microorganisms. Although the antibacterial activity of these peptides already has been proven, studies have shown that antibacterial peptides can also play other roles. In this study, a novel peptide was identified from the skin secretion of the tree frog from South America, Phyllomedusa …
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