Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"antiplatelet"”.
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Antiplatelet and antihypertensive actions of ridogrel
Thromboxane plays a principal role in platelet aggregation, and is a potent vasoconstrictor. It is now understoood, that the receptor for thromboxane (TP) responds to multiple endogenous ligands. Inhibiting the synthesis of thromboxane does not prevent functional responses mediated by TP receptors. …
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Genotype- versus phenotype-directed personalization of antiplatelet treatment in Koreans with coronary artery disease undergoing coronary stenting
… of patients with HOPR at the baseline. Tailored antiplatelet therapy according to point-of-care genetic and phenotypic testing is feasible and effective in decreasing HOPR after 30 days.
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Comparing long-term antiplatelet strategies to prevent morbidity and mortality in patients with drug-eluting coronary stents
Background: The optimal long-term antiplatelet therapy (APT) that balances the benefit of preventing myocardial infarction (MI) with the risk of severe bleeding is unknown in patients greater than one year after drug-eluting stent (DES) placement. Methods: We modeled life expectancy (LE) using …
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The Effect of Tranexamic Acid on Transfusion Requirement in Dual Antiplatelet-Treated Anemic Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery
… (CABG). As these patients are frequently on dual antiplatelet therapy, the two coexisting conditions could potentially increase the risk of bleeding and transfusion. The aim of this study was to evaluate the effect of tranexamic acid (TA) on blood loss and transfusion in preoperatively anemic …
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Microfluidic Approaches to Thrombosis and Hemostasis: Towards a Patient-Specific Test of Antiplatelet Therapeutics and the Assessment of Coagulopathy in Hemophilic and Trauma Patients
… to in vivo or in vitro aspirin, a common antiplatelet therapy over collagen type I surfaces at venous shear rates. Utilizing the same flow assay, we also characterized mechanism-based resistance to aspirin conferred by non-steroidal anti-inflammatory drugs. Furthermore, we have also …
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Chrysophanol-8-O-glucoside Attenuates Platelet Activation Through Inhibiting MAPK and PKCε
… effects including antiinflammatory and antiplatelet effects. In the present study, we investigated the effect and mechanism of anthraquinone derivative isolated from rhubarb on platelet activity. Of four anthraquinone derivatives isolated from rhubarb examined, chrysophanol-8-O-glucoside …
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Uso do ácido acetilsalicílico na prevenção de doenças cardiovasculares.
… been considered for many years as the standard antiplatelet secondary prevention of vascular diseases, therefore, their effectiveness is independent of sex or age associated diseases such as diabetes or hypertension. Over time, other antiplatelet agents began to be chosen as a substitute for …
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Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivatives
… mixture) (BAA/OAA) were investigated for their antiplatelet aggregation, anti-inflammatory, anticoagulant, anti-oxidant and cytotoxicity activity. The compound structures were confirmed through spectral nuclear magnetic resonance (NMR), mass (MS) and infrared (IR) spectroscopy data analysis. The …
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Novel Agonists and Antagonists of Platelet Receptors
… which makes P2Y12 a target in pharmaceutical antiplatelet therapies. As a complement during revascularization surgery, mild hypothermia has been accepted, but its effect on platelet activation is unclear. We performed a comparative ex vivo study on platelets, treated with mild hypothermia and …
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The Molecular Mechanism of Platelet Activation in Inflammation
… suppressed activation. Additionally, the antiplatelet agents aspirin and cangrelor significantly reduced histone mediated activation by targeting thromboxane A2 and P2Y12 receptor-mediated pathways, respectively. These findings suggest that histones directly disrupt the platelet membranes, …
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Synthetic, Sulfated, Lignin-Based Anticoagulants
… inhibition of thrombin catalysis; and as an antiplatelet agent, by competing with platelet GPIbα. These mechanisms are comparable in potency to low molecular weight heparins currently used in the market, indicating that targeting exosite 2 may yield clinically useful drugs in the future. …
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Retrospective evaluation of the rockall risk scoring system in patients with nonvariceal upper gastrointestinal hemorrhage at a community hospital
… resources utilized and evaluated whether certain antiplatelet agents, anticoagulants, and NSAIDS affected the Rockall scores. The Rockall scoring system identified 21% of patients as having low Rockall scores, with no significant differences in length of stay between risk groups. Our study shows …
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Evaluating Risk of Delayed Major Bleeding in Critically Ill Trauma Patients
… included: male gender, pre-injury use of the antiplatelet agents aspirin and/or clopidogrel, presence of intracranial bleeding, higher injury severity scores, requirement of massive transfusion, and low pH values. Use of anticoagulant prophylaxis was not associated with delayed major bleeding. …
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Re-evaluation of the in vitro activity of the protease activated receptor-1 (PAR1) pepducin PZ-128
… of the leading causes of death globally, with antiplatelet agents commonly used for the clinical management of these conditions. Unfortunately, not all patients respond to existing antiplatelet therapies, which can result in vascular event recurrence and death. This has led to the need to …
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Antithrombotic and anti-inflammatory activity of ethyl acetate extract of Protorhus longifolia stem bark
… was determined in rat whole blood clot, the antiplatelet aggregation activity was evaluated on rat platelet rich plasma. The carrageenan induced rat paw edema and rat tail bleeding time models were used to investigate the anti-acute inflammatory and antithrombotic activity of the extract, …
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Clinical outcome and Predictive factors of Coronary aneurysm after Percutaneous Coronary Intervention
… favorable clinical courses with continuous dual-antiplatelet therapy (Ahn et al., 2010) although poor clinical outcomes including in-stent restenosis and stent thrombosis after drug-eluting stent (DES) implantation were increased with CAAs after DES implantation (James et al., 2009). In this …
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Investigating small-molecule inhibitors of platelet aggregation
… to prevent thrombotic events. However, current antiplatelet drugs have several drawbacks such as the increased risk of bleeding, difficulty in fine-tuning the antiplatelet effects of irreversible antagonists, and variability in patient response. Furthermore, the nucleoside-based, reversible drug …
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Electrolyte-gated graphene field-effect transistors : modeling and applications
… metabolism of clopidogrel, a widely prescribed antiplatelet medication. The graphene EGFETs, however, failed to sense an increase in DNA concentration. Further optimization of the PCR mix is required to ensure that increased DNA concentration lowers the PCR mix pH without rendering the DNA …
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Development and experimental validation of a novel arterial thrombosis-on-a-chip microfluidic device
… ‘off-site’ activity can mask the efficacy of antiplatelet compounds, but these erroneous effects were removed by the addition of downstream EDTA-solution. I then showed that the EDTA-quenched design is sensitive to differences in concentration of eptifibatide, further supporting it as an …
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