Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"antiplasmodial"”.
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Antiplasmodial/Antipyretic activity of some Zulu medicinal plants
… antioxidant, in vivo antipyretic and in vitro antiplasmodial activities as well as the cytotoxicity of the nine plants. The study also aims to isolate and purify the active compound in the most active plant extract. Material and methods Plants obtained from the muti market were botanically …
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Synthesis of aminomethylthiazole analogues for evaluation as antiplasmodial agents
… the synthesis, characterisation, and antiplasmodial evaluation of aminomethylthiazoles and related analogues are reported.
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Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation.
Trema orientalis, a widely distributed evergreen tree with various medicinal properties including the treatment of malaria, was investigated as a potential source of new antimalarial lead compounds. Organic extracts of the young growing twigs of T. orientalis were reproducibly shown to be active …
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Mono- and multinuclear PGM complexes containing thiosemicarbazones synthesis, characterization and antiplasmodial evaluation
Four aryl- and ferrocenyl-derived thiosemicarbazone ligands have been synthesized and characterized using NMR, infrared (IR) spectroscopy and mass spectrometry. These ligands were used towards the synthesis of three series of mono- and multinuclear complexes, in which the thiosemicarbazone ligands …
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Isolation and Structure Elucidation of Antiproliferative and Antiplasmodial Natural Products from Plants
… investigated for their antiproliferative and antiplasmodial activities. With the guidance of bioassay guided fractionation, two known antiproliferative terpenoids (2.1 and 2.2) were isolated from Hypoestes sp. (Acanthaceae), four known antiplasmodial liminoids (3.1-3.4) were isolated from …
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Synthesis, biological activity and physicochemical properties evaluation of antiplasmodial pyrimido[1,2-a]benzimidazoles
Malaria is an infectious disease which still causes high morbidity and mortality rates among the world's poorest populations, especially in tropical and sub-tropical regions. In 2020, 241 million malaria cases and 627 000 associated deaths were reported, with 94% of them on the African continent, …
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Synthesis and biological evaluation of thiazole and metergoline derivatives as antimycobacterial and antiplasmodial agents
… scaffold. These derivatives exhibited moderate antiplasmodial activity in the CQS strain of P. falciparum, and good antimycobacterial activity on the H37Rv strain of M.tb. A 2-pyridyl group at position 4 of the thiazole ring as well as a substituted phenyl at position 2 was found to be essential …
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The isolation, characterization and antiplasmodial activity of two novel dimeric sesquiterpenes from Dicoma anomala
The study investigates the antimalarial potential of a Southern African traditional medicinal plant, Dicoma anomala (Sond.). The plant is used to treat a variety of treatments including fevers. The extracts of the leaves and twigs have been reported to treat malaria and fever but the treatments …
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Structure-activity relationship studies of 2-phenylbenzimidazoles and related organometallic complexes as antiplasmodial agents
… potential drug candidates, displaying potent antiplasmodial activity. Furthermore, benzimidazoles can be chemically transformed into metal-containing organometallic complexes that elevate generally flat benzimidazoles to the third dimension. To date, examples of metal-containing benzimidazoles …
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Synthesis and antiplasmodial structure-activity relationships for some novel 4-aminoquinolines and 5-chlorobenzimidazoles
… via a versatile 6-step route and their antiplasmodial activities against the chloroquine sensitive D10 strain of Plasmodium falciparum have been investigated in vitro. A quantitative structure activity analysis of these compounds showed an excellent correlation of log ICso, corrected for …
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The antiplasmodial, toxicity and pharmacokinetic properties of synthetic derivatives of the natural product Curcumin
Includes bibliographical references.
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Quinoline-triazole half-sandwich iridium(III) complexes: Synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies
… an increasingly popular method of enhancing antiplasmodial activity in the drug-resistant parasite strains. Two series of 7-chloroquinoline-1,2,3-triazole ligands, one with the direct attachment of the triazole to the quinoline and one where the two entities are separated by an aminopropyl …
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In Vitro Antiplasmodial activity and phytochemicals screening of ethnomedicinal plants used to treat Malaria associated symptoms
A thesis submitted in fulfillment of the requirement of the Degree of Master of Science.
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Mono- and polynuclear Ferrocenyl-derived complexes: synthesis, characterisation and biological evaluation as antimycobacterial and antiplasmodial agents
Ferrocene-containing precursors, vinylferrocene and (E)-4-vinylferrocenylbenzaldehyde were prepared, by a Wittig olefination reaction and Heck cross-coupling reaction, respectively. Mononuclear ferrocenyl-derived imino complexes were synthesised by Schiff-base condensation reactions of …
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Synthesis, characterisation and pharmacological evaluation of silicon-containing aminoquinoline organometallic complexes as antiplasmodial, antitumor and antimycobacterial agents
… compounds were found to exhibit moderate to high antiplasmodial activities against the NF54 and Dd2 P. falciparum strains, with IC50 values in the nanomolar range for the ferroquine-derivatised series. The heterometallic series shows superior biological activity, suggesting that different metals …
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Isolation and characterization of antiplasmodial compounds from Siphonochilus aethiopicus and Aloe ferox and bioavailability of a novel furanoterpenoid
Includes abstract. Includes bibliographical references (leaves 138-162).
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Synthesis, pharmacological and solubility evaluation of antiplasmodial pyrido[1,2-a]benzimidazoles with cyclic and functionalized amine side chain substituents
… have previously been shown to possess potent antiplasmodial activity, but their in vivo antimalarial activity is limited by poor oral bioavailability arising from low aqueous solubility. The mechanism of action of PBI antimalarials remains unknown. In an attempt to address these initial …
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The application of the Multi-Component Reaction (MCR) strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents
… and tetrazole-scaffolds, which exhibit in vitro antiplasmodial and antimycobacterial activity.
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Totarol as privileged natural product scaffold for antimalarial drug discovery
… scaffold “totarol", which possesses inherent antiplasmodial activity, was used to design and investigate the antiplasmodial activity of three different compound classes namely: Mannich bases, aminoalcohols and semicarbason derivatives. The aim was to incorporate important drug fragments into a …
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