NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 35 for “"antioxidant response"”.

  1. Characterizing ERAD and Antioxidant Response in Ixodes scapularis ISE6 Cells during Borrelia Infection

    Downs, Latoyia2021

    … To prevent cellular damage, the tick utilizes an antioxidant system to neutralize ROS and mechanisms to mitigate ER stress. There is very little to no research on BM<em> </em>and BB<em> </em>infection within the tick vector<em> </em>that contribute to understanding its molecular mechanism of …

    usm Repository record

  2. Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite

    Cox, David Paul

    … via modulation of intracellular glutathione. In response to changes in glutathione, changes in hOgg1 transcription occur similar to genes regulated by the transcription factor Nrf2. It was determined that positions - 47 to - 44 in the hOgg1 promoter are necessary for basal transcription of Ogg1 …

    montana-tech Repository record

  3. Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite

    Cox, David Paul

    … via modulation of intracellular glutathione. In response to changes in glutathione, changes in hOgg1 transcription occur similar to genes regulated by the transcription factor Nrf2. It was determined that positions - 47 to - 44 in the hOgg1 promoter are necessary for basal transcription of Ogg1 …

    montana Repository record

  4. DIFFERENTIATION-INDUCED CHANGES IN ANTIOXIDANT CAPACITY AND ANTIOXIDANT RESPONSE IN SH-SY5Y CELLS: ROLE OF NRF2

    Karikari, Akua Afriyie2014

    … reactive oxygen species are counterbalanced by antioxidant defense systems such as the Nrf2-ARE pathway, the primary regulator of endogenous antioxidant response. Whereas neuronal cells are post-mitotic and are particularly susceptible to oxidative stress because of high oxygen consumption, …

    montana-tech Repository record

  5. DIFFERENTIATION-INDUCED CHANGES IN ANTIOXIDANT CAPACITY AND ANTIOXIDANT RESPONSE IN SH-SY5Y CELLS: ROLE OF NRF2

    Karikari, Akua Afriyie2014

    … reactive oxygen species are counterbalanced by antioxidant defense systems such as the Nrf2-ARE pathway, the primary regulator of endogenous antioxidant response. Whereas neuronal cells are post-mitotic and are particularly susceptible to oxidative stress because of high oxygen consumption, …

    montana Repository record

  6. Impact of an Acute Bout of Low- and High-Frequency Neuromuscular Electrical Stimulation on Voluntary Muscle Fatigue and Antioxidant Response

    Khan, KhizraTexas State University2026

    … (20 Hz) NMES on skeletal muscle fatigue and antioxidant biomarkers in healthy, young adults. METHODS: Fifteen participants (9 females, 6 males; mean age 23.9 ± 4.3) completed this randomized crossover design study. The student was conducted over 3 study days: On Day 1 Maximal Voluntary …

    texas-state Repository record

  7. Bioavailability of blueberry-derived phenolic acid metabolites and their activity in endothelial cells

    Tang, JeffryResearchSpace@Auckland2018

    … the ability of each mixture to induce cellular antioxidant response proteins regulated by nuclear factor erythroid 2-related factor 2 (Nrf2) or to reduce endothelial cell monocyte adhesion under pro-inflammatory challenge with tumour necrosis factor alpha (TNFα), was investigated in cultured …

    auckland-ms Repository record

  8. Modulation of the Expression of Multidrug Resistance Proteins by Sulforaphane and Erucin

    Harris, Kristin E.University of Illinois at Urbana-Champaign2007

    … binding of the Nrf2 transcription factor to the antioxidant response element (ARE) in the promoter region of target genes. Because SF and ER increased MRP1 expression at the mRNA level, we investigated the impact of these compounds on MRP1 transcription. Non-small cell lung cancer cells (A549) …

    uiuc Repository record

  9. Elucidating the Structural and Dynamical Properties of the Intrinsically Disordered Protein Nrf2 Using Molecular Dynamics Simulations

    Chang, Megan NicoleThe University of Western Ontario2021

    … critical transcription factor for activating the antioxidant response pathway, a primary defense mechanism against disproportionate levels of oxidants in the cell, via the upregulation of cytoprotective genes. Notably, aberrant activation of Nrf2 in cancer cells increases their resistance to …

    uwo Repository record

  10. Developmental origins of cortical circuit dysfunction in a 22q11 deletion mouse model

    Rukh, ShahVirginia Tech2026

    … and reduced neurite growth. Treatment with the antioxidant N-acetylcysteine (NAC) improved axonal and dendritic growth but did not restore expression of deleted or differentially expressed genes in LgDel PNs. Instead, NAC induced a distinct antioxidant response via Nrf2 signaling pathway. …

    vt Repository record

  11. Characterization of the Molecular Mechanisms of Xenobiotic-Induced NRF2 Activation for Disease Prevention and Intervention

    Rojo de la Vega Guinea, Elisa MontserratThe University of Arizona.2018

    … 2 (NRF2) is the master regulator of the cellular antioxidant response upon exposure to xenobiotics. In addition, NRF2 induces the expression of genes involved in drug metabolism, protein homeostasis, anabolic metabolism, inflammation, proliferation, and survival. Understanding the molecular …

    arizona-thes Repository record

  12. Breast Cancer Inhibition by Grape Constituents

    Jung, Kwan JaeUniversity of Illinois at Urbana-Champaign2015

    … which could suppress cancer such as having antioxidant, antiproliferative, and proapoptotic actions. To determine the potential breast cancer protective action of purple grape juice, we examined the effect of grape juice consumption on the initiation stage of 7,12-dimethylbenz[a]anthracene …

    uiuc Repository record

  13. Identification of Anti-inflammatory and Antioxidant Properties of MangostinXanthones in Adipocyte Reporter Assays

    Shen, QiwenThe Ohio State University2013

    … line that stably expressed nuclear factor κB response element (<i>Nfkb</i>-RE)/GFP, fatty acid binding protein 4 promoter (<i>Fabp4</i>-P)/CFP, and nuclear factor erythroid 2-related factor2 promoter (<i>Nrf2</i>-P)/YFP fluorescent reporters. We hypothesized that fluorescent signals directly …

    ohiolink Repository record

  14. Environmental Stressors: Pathways Of Exposure And Aquatic Invertebrate Response

    Nowicki, Carly Jean2014

    … <em>Dreissena bugensis</em> had a stronger OS response than <em>D. polymorpha</em> in single stressor conditions (p < 0.050); however, in multiple-stressor treatments <em>D. bugensis</em> had increased oxidative damage and was less tolerant to additional stressors. My results establish a …

    wayne-thes Repository record

  15. Molecular Adaptation of Pancreatic Beta-Cell Function During Endoplasmic Reticulum Stress

    Kitiphongspattana, KajornUniversity of Illinois at Urbana-Champaign2015

    … in the ER, especially during an unfolded protein response (UPR). Using a beta-cell line (MIN6) and mouse islets, endogenous production of ROS, the GSH/GSSG couple, and expression of genes involved in oxidative protein folding (i.e., ERO1 and PDI) and antioxidant defense were measured. Endogenous …

    uiuc Repository record

  16. Μελέτη του μεταγραφικού παράγοντα NRF2 ως διαμεσολαβητή της δράσης των στατινών

    Χαρτουμπέκης, Διονύσιος2011

    … DNA στην οποία προσκολλάται ο Nrf2 (ARE-Antioxidant Response Element) (ARE-ST2 κύτταρα), η σιμβαστατίνη αύξησε τη μεταγραφική ενεργότητα του Nrf2 με τρόπο εξαρτώμενο από το μεβαλονικό και ανεξάρτητο από τη χοληστερόλη. Επίσης, χρησιμοποιώντας πρωτογενείς καλλιέργειες εμβρυϊκών ινοβλαστών …

    patras-thes Repository record

  17. Regulation of The Oxidative Stress Response By Arid1A

    Kwan, Suet Yan2016

    … cancers.</p> <p> In this study, drug responses between <em>ARID1A</em>-wildtype and <em>ARID1A</em>-mutant cell lines were compared using the ‘Genomics of Drug Sensitivities in Cancer’ database. From this analysis, I found that <em>ARID1A</em>-mutant cell lines are more sensitive to …

    uthsc Repository record

  18. Oxidativer Stress- assoziierter neuronaler Zelltod und die Identifikation neuroprotektiver Gene durch ein neuartiges Screening-System

    Zitzler, JuergenLudwig-Maximilians-Universität

    … werden. Nrf2 aktiviert die Transkription sog. „antioxidant response element (ARE)“-regulierter Antioxidanzien und detoxifizierender Enzyme, und wirkt somit indirekt schützend. Für Gfat-2 war bisher noch kein direkter Zusammenhang für die Protektion vor oxidativem Stress beschrieben. Mit der …

    lmu-germany Repository record

  19. Development of a pericyte-based strategy to recover aged skeletal muscle after disuse

    Wu, Yu-FuUniversity of Illinois at Urbana-Champaign2022

    … in pericytes suggested disruption to antioxidant production. To test this hypothesis, pericytes were obtained from healthy or immobilized skeletal muscle and exposed to a hydrogen peroxide load in vitro. Only the healthy pericytes were able to mount an antioxidant response to oxidative …

    uiuc Repository record

  20. Mechanisms of monohalogenated acetic acid induced genomic DNA damage

    Pals, JustinUniversity of Illinois at Urbana-Champaign2014

    … analysis and with the production of an antioxidant response element driven reporter gene. The antioxidant butylated hydroxyanisole and the intracellular Ca2+ chelator BAPTA-AM reduced genomic DNA damage induced by each of the monoHAAs, supporting the hypothesis that monoHAAs induced …

    uiuc Repository record

Page 1 of 2