Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"antinociceptive"”.
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Antinociceptive actions of descending catecholaminergic tracts on dorsal horn somatosensory neurones
Ionophoretically-applied dopamine and noradrenaline selectively inhibited the nociceptive responses of multireceptive somatosensory dorsal horn neurones, whilst non-nociceptive responses, spontaneous activity and activity evoked by an ionophoretically-applied excitatory amino acid, DL-homocysteic …
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The clinical relevance of endorphin receptors: the antinociceptive effectiveness of epidurally or intrathecally injected endorphinomimetics
Contains fulltext : mmubn000001_027417336.pdf (Publisher’s version ) (Open Access)
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Enhancing the use of opioids in pain management: antinociceptive potentiation with opioid agonist/antagonist combinations.
While opioids are the most effective and widely used class of drug for the management of moderate to severe pain, their use may be limited by adverse effects that are unpleasant and potentially dangerous. Research is increasingly directed towards strategies to improve the use of opioids in pain …
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Evaluation of the antinociceptive, anti-inflammatory and antipyretic activities of Ruta Graveolens L. in mice and rats
Evaluation of the antinociceptive, anti-inflammatory and antipyretic activities of Ruta graveolens L. in mice and rats FIRDOWS LOONAT M. Pharm. Pharmaceutical Sciences thesis: School of Pharmacy, University of the Western Cape Ruta graveolens (Rutaceae) L. is a medicinal plant that is commonly used …
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Heritability of Nociception and Antinociception in the Laboratory Mouse
"Nociceptive and antinociceptive variability has been demonstrated in the mouse; a proportion of this variability is due to inherited genetic factors. We present genetic correlation analyses of 22 nociceptive measures among a common set of inbred mouse strains, revealing the existence of five …
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Óleos essenciais com atividade antinociceptiva : uma revisão.
… This review describes the studies about antinociceptive activity of essential oils. In the literature survey done in five years, studies with preclinical trials involving essential oils from 36 plant species we re found with antinociceptive activity. The main models of nociception were …
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Molecular Characterization of the Opioid Receptors: Design, Development, and Preclinical Evaluation of Salvinorin A-Based Molecular Probes.
… potentially useful clinical applications (e.g. antinociceptive, anti-addictive, antipruritic, neuroprotective, etc.). This has encouraged the development of analogues as essential molecular probes to elucidate the structure-activity-relationship of the salvinorin-class.</p> <p>In this study, we …
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Indagine etnofarmacologica su Casimiroa edulis Llave et Lex
… anticataleptic, anticonvulsant, antinociceptive and antinflammatory activities. The results revealed that the extract of seeds reduced spontaneous motor activity and rearing; in the forced swimming test (FST) it caused a potent sedative effect; in the test of carrageenan-induced …
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Investigação da atividade psicofarmacológica do extrato etanólico bruto de Sargassum polyceratium em modelos animais utilizando roedores
… extract from Sargassum polyceratium presents antinociceptive activity.
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Dual Mechanism Analgesia-Enhancing Agents
… MD-354, inactive by itself, potentiates the antinociceptive effects of an inactive dose of clonidine in the mouse tail- flick assay. An attempt to determine the underlying mechanism of this potentiating effect was the purpose of the present investigation. The studies focused on an examination …
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The Contribution Of Nmda Receptors Within The Central Nucleus Of The Amygdala To The Suppression Of Pain Affect
… of the CeA, the agonist likely activates antinociceptive efferents at the level of the vlPAG. In support of this hypothesis, the present study revealed that Fos expression within vlPAG is greater in rats that received intra-CeA agonist NMDA treatment compared to those that received the …
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CaMKIIbeta in Pain and Addiction
… I utilized this model to also study morphine antinociceptive tolerance and dependence, where I discovered that CaMKIIβ contributes to both processes. Overall, this work explores the role of CaMKIIβ in chronic inflammatory and neuropathic pain as well as SCD associated pain and OIH. It uncovers …
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Cyclodextrins as a suitable carrier for the induction of feeding and analgesia by Delta-9 THC: a preclinical study in the female rat
… Acute dosing with 3 mg/kg produced robust antinociceptive effects, evidenced by increased tail-flick latency, whereas chronic treatment revealed only mild tolerance, with analgesic efficacy sustained over 15 days. Regarding feeding behavior, low-dose (0.3 mg/kg) THC–HP-β-CD transiently …
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Increased Microglial Reactivity Alters Morphine Analgesia
… variable mechanisms causes a reduction in the antinociceptive response to morphine in rodents. In conclusion, the work of this thesis has identified novel targets (P2X7R and Runx1) for interfering with the side effects associated with prolonged opioid use and in the acute analgesic response.
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Bioactive Lipids in Nociception
… PGE2 level in brain, only acetaminophen displays antinociceptive activity in animal tests of acute non-inflammatory pain, indicating that other mechanisms than central cyclooxygenase inhibition must be sought to explain the analgesic effect of acetaminophen in these tests. Knowledge of the …
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EFFECTS OF MU OPIOID RECEPTOR AGONISTS ON INTRACRANIAL SELF-STIMULATION IN THE ABSENCE AND PRESENCE OF “PAIN” IN RATS
… further depression of ICSS and reduced the antinociceptive potency of both methadone and nalbuphine. Morphine antinociception was resistant to tolerance in the assay of acid-depressed ICSS. Overall, these results provide a basis for comparing determinants of abuse-related opioid effects in …
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Spotting pain in the brain. Towards a useful animal model of pain
… of pain. As part of this, differentiating the antinociceptive outcome of drugs would clarify confounding sedative properties of drugs when assessing analgetic effects. Surface electrodes or ultrathin implantable electrodes were used to record the transmission to SI. We show that both a sedative …
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Secondary Metabolites from Otanthus maritimus, Stachys glutinosa and Withania somnifera: Isolation, Structure Elucidation and Interactions with Cannabinoid and Opioid Systems
… the most potent and abundant compounds in antinociceptive experiments in mice. A total of 30 secondary metabolites were isolated from the extracts. Two semisynthetic derivatives were also prepared. The OME yielded two new alkylamides and one new neo-‐lignan , along with thirteen known …