Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"antinociception"”.
-
Heritability of Nociception and Antinociception in the Laboratory Mouse
… descending inhibitory circuitry, and may affect antinociception indirectly, via primary action on baseline nociceptive sensitivity. We similarly assessed the pharmacogenetics of three over-the-counter analgesics, but using a more sensitive nociceptive assay due to the weak efficacy and potency of …
-
Electrical stimulation of the ventral lateral periaqueductal gray induces antinociception in rats
… key behavioral states of general anesthesia is antinociception (reduced sensitivity to pain). Within the nociceptive pathway in the brain and the central nervous system, the periaqueductal gray (PAG) has been shown to be a key site that modulates antinociception responses. We hypothesize that …
-
Effect of cannabinoids on pain-stimulated and pain-depressed behavior in rats
Cannabinoids produce antinociception in many preclinical models of acute and chronic pain. In contrast, cannabinoids produce inconsistent analgesia in humans, showing little or no efficacy in treating acute pain, with modest efficacy in treating chronic inflammatory pain. This discrepancy may …
-
Ultra-Low Dose Antagonist Effects on Cannabinoids and Opioids in Models of Pain: Is Less More?
… groups of Long Evans rats were tested for antinociception following an injection of vehicle, the cannabinoid agonist WIN 55 212-2 (WIN), the opioid antagonist naltrexone (an ultra-low or a high dose), or a combination of WIN and naltrexone doses. Ultra-low dose naltrexone elevated …
-
Enhancing the use of opioids in pain management: antinociceptive potentiation with opioid agonist/antagonist combinations.
… antagonist. A recent animal study reported that antinociception may be significantly enhanced with the combination of the partial opioid agonist/antagonist buprenorphine and ultra-low doses of the antagonist naloxone. The central aim of the studies described herein was to investigate the effect …
-
Molecular Mechanisms by Which HSP90 Inhibition in the Spinal Cord Enhances Opioid Receptor Signaling
… 17-AAG-enhanced morphine (subcutaneous, SC) antinociception in the tail flick test and paw-incision pain model in both male and female mice. Conversely, the AMPK inhibitor dorsomorphin (i.t) and the EGFR inhibitor Afatinib (i.t) enhanced morphine antinociception greater than 17-AAG alone. …
-
Pain-modulating effects of peripheral (CB2) cannabinoid receptors
… the CB1, receptor in the production of antinociception, inflammatory hyperalgesia, and peripheral nerve injury-induced sensory hypersensitivity. In previous work included in my masters thesis, our laboratory has demonstrated the capacity of CB2 receptors located outside the central …
-
Functional and molecular approaches to study mu and delta opioid receptor hetero-oligomerization in a model of neuropathic pain
… that bind M/DOR produced enhanced thermal antinociception and reversed mechanical allodynia in NP rats. DOR agonists that have low binding affinity for M/DOR did not produce enhanced thermal antinociception but did reverse mechanical allodynia in NP rats. Molecular studies were employed to …
-
Discriminative stimulus properties of 3-substituent rimonabant analogs
… activity and body temperature and produce antinociception and catalepsy. Drugs that produce this tetrad of effects within a limited dose range are likely to function as CB1 receptor agonists. A structure activity relationship study from our laboratory investigating analogs of the CB1 …
-
Dual Mechanism Analgesia-Enhancing Agents
… receptors and α2B- adrenoceptors play a role in antinociception. MD-354, N-(3-chlorophenyl)guanidine, has a high-affinity both for 5-HT3 and α2B- adrenoceptors and could be viewed as the first example of a rather selective 5-HT3/α2B- adrenoceptor ligand. MD-354, inactive by itself, potentiates …
-
Functional Characterization of CRIP1a Knockout Mice
… Surprisingly, sensitivity to agonist-induced antinociception, hypothermia, catalepsy or motor incoordination did not differ between genotypes. Our findings suggest that CRIP1a could play a selective role in modulation of anxiety by endocannabinoids, and this action could be mediated through …
-
Measuring Nociception Under Anesthesia
… stimulation to determine the degree of antinociception more accurately on a subject-by-subject basis than the ANI. In summary, I have: 1) constructed and validated quantitative multi-dimensional measures of intraoperative nociceptive state using HRV and EDA; and 2) compared these …
-
EFFECTS OF MU OPIOID RECEPTOR AGONISTS ON INTRACRANIAL SELF-STIMULATION IN THE ABSENCE AND PRESENCE OF “PAIN” IN RATS
… of both methadone and nalbuphine. Morphine antinociception was resistant to tolerance in the assay of acid-depressed ICSS. Overall, these results provide a basis for comparing determinants of abuse-related opioid effects in the absence of pain with their affective analgesic effects in the …