Global ETD Search

Synthesis of furo[2,3-d]pyrimidines, thieno[2,3- d]pyrimidines, pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolates, receptor tyrosine kinase (RTK) inhibitors and antimitotic agents

Zhang, Xin2018

… tyrosine kinase (RTK) inhbitors and anti mitotic agents has been discussed. Thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFTase) are important folate dependent enzymes that are targets for cancer chemotherapy and the treatment of …

duquesne Repository record for Synthesis of furo[2,3-d]pyrimidines, thieno[2,3- d]pyrimidines, pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolates, receptor tyrosine kinase (RTK) inhibitors and antimitotic agents (opens in a new tab)

Synthesis of Bicyclic Thieno[2,3-d]Pyrimidines, Tricyclic Thieno[2,3-d]Pyrimidines and Thieno[3,2-d]Pyrimidines as Classical and Nonclassical Antifolates

Zhou, Xilin2018

… progress in the areas of antifolates and antimitotic agents has been reviewed and discussed. Thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFTase) are important folate dependent enzymes that are targets for cancer chemotherapy …

duquesne Repository record for Synthesis of Bicyclic Thieno[2,3-d]Pyrimidines, Tricyclic Thieno[2,3-d]Pyrimidines and Thieno[3,2-d]Pyrimidines as Classical and Nonclassical Antifolates (opens in a new tab)

Synthesis and Molecular Pharmacology of the Diazonamides

Burgett, Anthony William George2010

… I determined that the diazonamides are potent antimitotic agents that induce the formation of mono-aster mitotic spindles. The synthesis of numerous analogs established structure activity relationships which guided the preparation of biotinylated, fluorescent, and radiolabeled forms of the …

utswmed Repository record for Synthesis and Molecular Pharmacology of the Diazonamides (opens in a new tab)

Cytological measurements of c-mitotic and prophase poison actions

Hadder, John Cortland, 1921-1957

Thesis (Ph. D.)--Michigan State University of Agriculture and Applied Science. Dept. of Botany and Plant Pathology, 1957

msu Repository record for Cytological measurements of c-mitotic and prophase poison actions (opens in a new tab)

Design and Synthesis of Pyrimidine Fused Heterocycles as Single Agents with Combination Chemotherapy Potential

Pavana, Roheeth2016

… of pyrimidine fused heterocycles as single agents with combination chemotherapy potential. Major limitations of cancer chemotherapy include dose limiting toxicities of clinically used agents and the development of multidrug resistance by the tumor. Agents that interfere with microtubules are …

duquesne Repository record for Design and Synthesis of Pyrimidine Fused Heterocycles as Single Agents with Combination Chemotherapy Potential (opens in a new tab)

Desarrollo de nuevos agentes antimitóticos relacionados con combretastatinas y fenstatinas

Álvarez Lozano, Raquel2009

salamanca Repository record for Desarrollo de nuevos agentes antimitóticos relacionados con combretastatinas y fenstatinas (opens in a new tab)