Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"antimicrobial therapy"”.
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Identification of Essential Outpatient Parenteral Antimicrobial Therapy (OPAT) Bundle Elements to Optimize Patient Outcomes in an Academic Health-System
Introduction Outpatient parenteral antimicrobial therapy (OPAT) services are becoming increasingly popular for institutions to implement due to the cost effectiveness and reduction in readmission rates for patients successfully started on appropriate therapy. OPAT services have varying …
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The application of a human factors approach to the evaluation of a novel outpatient parenteral antimicrobial therapy service in Malta.
The application of a human factors approach to healthcare has been gaining traction ever since its first mention in the early 1960s. The need for this synergistic collaboration stems from the poor safety and quality outcomes that have been plaguing the history of healthcare, despite continuous …
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Molecular Diagnosis of Lower Respiratory Tract Infection in the Paediatric Intensive Care Unit
The World Health Organisation describes antimicrobial resistance (AMR) as one of the biggest threats to global health. One of the drivers of AMR in healthcare settings is the overuse of broad-spectrum antimicrobials. For severe infections, paediatricians must prescribe antimicrobial therapy …
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Control of Shigella sonnei and adhesive invasive Escherichia coli infections with a natural product which inhibits the bacterial oxidoreductase DsbA
… of hyperinflammation. These infections require antimicrobial therapy. However, due to the widespread emergence of multiple drug-resistant strains, alternative strategies must be sought to combating infectious diseases. It has been shown that natural compounds such as propolin D are able to …
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Development of A Molecular Gram-Stain Assay For The Diagnosis of Blood Stream Infections Associated With Sepsis
… affects the administration of the correct antimicrobial therapy.</p> <p>I have designed, developed, and begun to validate a rapid, sensitive, and specific DNA-based quantitative PCR (qPCR) assay, designated the Molecular Gran- stain (MGS) assay, to detect bacterial pathogens directly from …
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BACTERIA ANALYSIS BY USING A SUPERVISED MACHINE LEARNING ALGORITHM BASED ON DROPLET MICROFLUIDICS
… study found that a 1-hour delay in appropriate antimicrobial care resulted in a 7% - 10% rise in mortality. Several professional societies seek to reduce sepsis mortality by targeting the timely use of diagnostic tests and antimicrobial therapy. The diagnostic instruments available to clinicians …
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Detection and Identification of Gastrointestinal Pathogens in Clinical Samples: Comparison Between two Laboratory Developed Multiplex Real-Time PCR Platforms
… Reducing delay of treatment, inconsistent antimicrobial therapy, and/or expensive medical care.</p> <h1> </h1>
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Utility of the biofire filmarray pneumonia panel plus assay for syndromic testing of lower-respiratory tract infections in a low-middle-income setting
… of results may lead to inappropriate antimicrobial therapy. Methods: The utility of the BioFire® FilmArray® Pneumonia Panel plus (FA-PP) to detect LRTI pathogens, and the potential antimicrobial stewardship impacts in a low resource setting, was assessed. Routine LRT samples were …
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Characterization of Clinical and Commensal Escherichia coli Isolates from an Integrated Turkey Operation
… by the diversity of poultry strains. Reliance on antimicrobials to control E. coli infections has caused widespread antimicrobial resistance. One hundred five clinical E. coli were obtained, and 1104 isolates were collected from fecal specimens of 20 flocks in an integrated turkey operation. …
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Analysis of the streptococcal cpsa protein in dna-binding and regulation of capsule and cell wall maintenance
… a phenotype that is associated with altered antimicrobial resistance and autolysis activity in S. iniae. Taken together, CpsA contributes to the complex regulatory scheme controlling capsule and cell wall, the two major constituents of bacterial cell surface macromolecular structure, and does …
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Structural and Functional Characterization of SPOA Domains in Salmonella Typhimurium Type III Secretion Systems
… raised concerns for the long term prospects of antimicrobial therapy. By understanding the mechanisms used by bacteria to manipulate their host and cause disease, it is hypothesized that we might more rationally approach anti-infective therapeutic design. Type III secretion systems (T3SS) are …
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Characterisation of bacteria by surface enhanced Raman spectroscopy (SERS)
… infections are common and usually require antimicrobial therapy; however, as antibiotic resistance is increasing, mortality and morbidity rates are also increasing, placing significant economic burden on healthcare systems worldwide. Therefore, rapid detection of bacterial species causing …
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Avaliação das bactérias isoladas em amostras biológicas em neonatos internados na unidade de terapia intensiva no Hospital Universitário Lauro Wanderley de João Pessoa
… bacterium is or is not resistant to the chosen antimicrobial therapy may also exacerbate the condition health of the patient. Neonatal hospitalized in the intensive care unit are more susceptible to acquiring hospital infections, because they have an immature immune system, present a stratum …
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Development of Drug Loaded Nanoparticles for Treatment of Mycobacterium avium Infection
… annually worldwide. Although treatment with antimicrobials can be curative, many people fail to complete the prescribed therapeutic regimen which can increase the risk of disease re-emergence, spread of infection to others and development of drug resistance. An improved approach is urgently …
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Combatting β-lactamase-mediated antimicrobial resistance: from novel assays for inhibitor discovery to new diagnostics
… mortality rates. Combatting β-lactamase-mediated antimicrobial resistance requires efforts in developing novel technologies for the discovery of new therapeutics, as well as diagnostic tests which can rapidly identify β-lactamase-producing pathogens. To address this need, we developed a novel …
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Optimization of N-(1-Adamantyl)-3-Aryl Acetamides as Novel Antimycobacterial Agents
… 10 million new cases per year. Current therapy for active TB pulmonary infections constitutes multiple-drug therapy for greater than six months. Treatment for MDR/XDR TB can extend for several years and includes medications with serious adverse event profiles. Nontuberculous …
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Evaluation of the pharmacokinetics, pharmacodynamics, and safety of enrofloxacin administration to pregnant mares
Antimicrobial therapy is necessary in pregnant mares affected by severe bacterial infections such as cellulitis, bronchopneumonia, or placentitis. Despite the many antimicrobials available for human use, very few antimicrobials are cost-effective and approved for use in the horse. Enrofloxacin is a …
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The Molecular Epidemiology of Enteric Fever in South and Southeast Asia
… limited. Typhoid management largely relies on antimicrobial therapy; however, antimicrobial resistance (AMR) in these causative pathogens has become a global threat, compromising the effectiveness of the treatment therapy and signifying the burden of this disease. Understanding the epidemiology …
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Developing novel therapies for Mycobacterium abscessus
… the development of novel treatment regimens and antimicrobial agents. I first analysed the treatment outcomes for the CF patients infected with M. abscessus at the Royal Papworth Hospital to examine whether specific antibiotic combinations were associated with better treatment outcomes and could …
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Assessing and improving rational antimicrobial use in urban and rural health care facilities in Vietnam
The global problem of antimicrobial resistance (AMR) is particularly pressing in developing countries including Vietnam, where the infectious disease burden is high and cost constrains the replacement of older antimicrobials with newer, more expensive ones. Along with surveillance and infection …
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