Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"antimicrobial target"”.
-
The biochemistry and phylogeny of CysE: An antimicrobial target
… prevalent bacterial STI. The rapid emergence of antimicrobial-resistant strains has led N. gonorrhoeae to being labelled as a priority pathogen for the development of new antimicrobials by the World Health Organisation. One strategy for identifying new antimicrobials is through targeting pathways …
-
Characterisation of the Essential t<sup>6</sup>A tRNA Modification Enzymes and Evaluation as a Potential Novel Antimicrobial Target
<p>Modified bases in RNA molecules are common, with over one-hundred individual modifications reported to date. In transfer RNA (tRNA), these modifications help hold the molecule in its proper conformation, allow the aminoacyl-synthetases to attach the amino acid to the correct tRNA for transfer to …
-
Genome scale metabolic modelling to identify metabolic responses of resistant bacteria to antibiotic challenges
Antimicrobial Resistance (AMR) is one of the most alarming public health threats being faced by humanity in present times, in every aspect from economic losses to social instability. The pace of antimicrobial target research is being overtaken by the pace of resistance developing among disease …
-
Investigation of O-acetylserine sulfhydrylase enzymes from bacterial pathogens as potential drug targets
Antimicrobial resistance (AMR) has emerged as a formidable global health crisis, necessitating the urgent development of novel antimicrobial strategies. Among the most concerning drug-resistant pathogens are Neisseria gonorrhoeae and Staphylococcus aureus, both of which lack a functional sulfate …
-
INVESTIGATION OF UNIQUE COENZYME A BIOSYNTHETIC AND REDOX FUNCTIONS IN Bacillus anthracis
… thus contributing to its validation as a new antimicrobial target. The intracellular cellular thiol-disulfide redox status of B. anthracis is maintained by coenzyme A-disulfide reductase (BACoADR), which catalyzes the NAD(P)H-dependent reduction of coenzyme A-disulfide (CoAD) to 2 CoASH. B. …
-
Characterization of ftsA conditional lethal mutants shows that FtsA is required at early and late stages of cell division in Streptococcus pneumoniae
… in S. pneumoniae and further validate it as a target to develop novel inhibitors active on septation. Moreover, the data suggest that an early block in cell division in S. pneumoniae impairs both growth and division, supporting a model in which a single machinery, containing both complexes, one …