Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 162 for “"antigen-presenting cells"”.
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Presentation Of Citrullinated Peptides Derived From Unmodified Protein By Antigen Presenting Cells.
… peptides derived from unmodified protein by antigen presenting cells. By Jamie Michelle Rimer Doctor of Philosophy in Biology and Biomedical Sciences: Immunology) Washington University in St. Louis 2010 Professor Emil R. Unanue, Chair Autoimmune responses to citrullinated proteins have been …
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Arenaviruses: the Role of Antigen Presenting Cells (APC) in Persistence and Immunopathology
… the virus-host interaction is a unique group of cells called the antigen presenting cells (APC). APC play a significant role in immune response, as the receptionist, they are the first cells to detect pathogen invasion and present the antigen to the cells of the adaptive immune system for …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
Antigen presenting cells (APCs) perform the essential task of integrating responses between the innate and adaptive immune system. Several approaches have been undertaken to manipulate the effects of APCs for therapeutic purposes. Panax notoginseng is a medicinal herb that is purported to possess a …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
Antigen presenting cells (APCs) perform the essential task of integrating responses between the innate and adaptive immune system. Several approaches have been undertaken to manipulate the effects of APCs for therapeutic purposes. Panax notoginseng is a medicinal herb that is purported to possess a …
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Elucidating the Role of Antigen-presenting Cells in the Immunopathogenesis of the Porcine Reproductive and Respiratory Syndrome Virus
… study was to investigate the role of specific antigen-presenting cell (APC) subsets during the pathogenesis of PRRSV and to further understand the progression to T cell immunity in response to PRRSV. To accomplish this, we chose to investigate the susceptibility of bone marrow-derived dendritic …
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Use of Cholera Toxin B as a Vaccine Adjuvant Activates Antigen Presenting Cells and Stimulates Production of Pro-Inflammatory Cytokines
… tularensis</em>, and their ability to present antigen to naïve T-cells, express costimulatory molecules, and produce pro-inflammatory cytokines. We found that RAW264.7 cells, a murine macrophage cell line, responded to treatment with <em>iFt+CTB</em> by an increased secretion of the …
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Activation of MAIT cells by antigen presenting cells: a comprehensive analysis and assessment of HIV and TB disease on these interactions
MAIT cells are non-classical, innate-like T lymphocyte subsets, which recognize microbial vitamin B metabolites and rapidly respond by producing pro-inflammatory cytokines such as IFN-γ, TNF-α and cytotoxic molecules, which may result in the killing of bacteria-infected cells. Unlike conventional T …
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Immunomodulatory activity of Lacticaseibacillus rhamnosus R0011: analysis of secretome-mediated impacts on innate immune outcomes in intestinal epithelial cells and antigen presenting cells
… and expression. While host intestinal epithelial cells (IECs) and antigen-presenting cells (APCs) can interact directly with both commensal and pathogenic bacteria through innate immune pattern recognition receptors, recent evidence indicates indirect communication mediated by soluble mediators …
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Biological effects of trogocytosis on CD4+ T lymphocytes
<p>Antigen recognition by CD4+ T cells leads to large-scale spatial and temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation, T cells capture large membrane fragments from antigen-presenting cells directly from the immunological …
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Biological effects of trogocytosis on CD4+ T lymphocytes
<p>Antigen recognition by CD4+ T cells leads to large-scale spatial and temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation, T cells capture large membrane fragments from antigen-presenting cells directly from the immunological …
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Active Inhibition of T Cell Proliferation by Monocytes
… and inhibition of peripheral blood mononuclear cells. In this study, it is shown that the inhibition of OKT3-dependent T cell activation correlates with metabolic activation of antigen presenting cells. In contrast, inhibition of lectin- and superantigen-mediated T cell activation may occur …
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Superantigens as vaccine delivery vehicles for the generation of cellular immune responses
… to evade their hosts. The production of superantigens is one of these mechanisms. Superantigens are potent T cell mitogens that have the unique ability to bind simultaneously to major histocompatibility complex (MHC) class II molecules and T cell receptors (TCRs). The resulting uncontrolled …
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Role of Splenic B Cells and Gamma Delta T Cells in the Induction of Peripheral Tolerance Elicited Through the Anterior Chamber of the Eye
… tolerance that is induced by introducing antigens into the anterior chamber (AC) of the eye, and is maintained by antigen-specific regulatory T cells (Tregs). ACAID regulates harmful immune responses that can lead to irreparable injury to innocent bystander cells that are incapable of …
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Cellular immunity of naïve and BCG vaccinated neonates
… be defective and related to the immaturity of antigen-presenting cells and/or T cells.
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MODELING, ANALYSIS, AND CONTROL OF SYK-MEDIATED SIGNALING EVENTS FOR B CELLS AND ASSOCIATED CELLULAR RESPONSE FOR B CELLS
… system and its responses to foreign threats (antigens) is a matter of understanding the immune cells involved, their individual responses, and chemicals responsible for intracellular and intercellular communication. The overall immune response is driven by individual actions of neutrophils, …
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Engineering T Cell Receptors for Potential Therapeutic Applications
… selections have involved incubating yeast cells with fluorescently labeled recombinant pepMHC ligand. Many pepMHC ligands are difficult to express and purify, so an alternative affinity selection strategy that obviates the need for this material would likewise facilitate affinity …
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The Role of Immunological Receptors CD74 and CD44 in Association with the Macrophage Migration Inhibitory Factor (MIF) on Human Breast Cancer Derived Cells
… mechanisms are not fully understood. In normal cells CD74 functions as a chaperone of human leukocyte antigen (HLA)-DR biosynthesis and is expressed in antigen presenting cells in the absence of tumours. Notably, CD44 is also a transmembrane receptor and member of a family of cell adhesion …
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OAdV7, an ovine adenoviral vector as a novel vaccine vector for tumour immunotherapy
… with the ability to efficiently transduce human cells and activate the innate immune system, making them one of the most popular viral vectors for vaccine development. To date, the majority of the studies in the literature have focused upon human adenovirus serotype 5 (HAdV5) for the development …
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pH-sensitive resist materials for combined photolithographic patterning of proteins and fluid lipid bilayers
… was to create a substrate mimicking an array of antigen- presenting cells. The substrate would consist of signaling ligand, biotin anti- CD3, bound to a lipid bilayer in a regular array of patches. The fluidity of the lipid bilayer would impart mobility to the signaling ligand. It was found that …
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Understanding the Role of Dendritic Cell Subsets in the Generation of a CD8+ T Cell Response Following Pulmonary Vaccinia Viral Infection
… the lung is constantly assaulted with foreign antigens, both environmental and infectious. This includes a large number of viruses which spread via aerosolized droplets. In order for the body to mount an adaptive immune response to a pathogen, T cells circulating through lymph nodes (LN) must …
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