Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"antigen uptake"”.
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Antigen presentation: Influence of Cell Type and Route of Antigen Uptake
… and CD8-DCIR2+ conventional DCs. To examine antigen processing and presentation in vivo, antigens were specifically targeted to CD8+ and CD8- DCs using chimeric monoclonal antibodies. We find that CD8- DCs are better than CD8- DCs for presentation of exogenous antigens onto major …
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Investigating The Role of Quaking In Antigen Uptake and Cross-Presentation By Dendritic Cells
… cells (DCs) are considered the most potent antigen presenting cells (APC) due to their superior capability of cross-presenting exogenous antigens to CD8<sup>+</sup> T cell for strong adaptive immune responses. They internalize foreign antigens by phagocytosis, endocytosis or …
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Elucidation of a Macrophage Cell Surface Receptor With Specificity for Exogenous Aromatic Hapten-Protein Antigens and Effects on Antigen Uptake and Processing
… interactions demonstrated that the kinetics of antigen uptake was dependent on the extent of receptor crosslinkage at the cell surface as well as on the accessibility of the ligand groups. Determination of the ligand-binding specificity of the macrophage receptor suggested preference for …
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Functional Responses of Lung Dendritic Cell Subsets in Flt3 Ligand-Induced Immunomodulation in Allergic Asthma
… inflammation, dendritic cells (DC) deliver antigen to T helper cells in the draining lymph nodes and induce a Th2 immune responses. An emerging concept is that DC subsets differentially skew T cell responses towards Th1 or Th2 immunity, or tolerance. Flt3-ligand (Flt3-L) is an indispensible …
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Uncovering Novel Mechanism of Immune Modulation of Invariant Natural Killer T Cells By Liposomal Α-Galactosylceramide
… CD8α<sup>+</sup>), they recognize glycolipid antigens via the MHC-class-I like molecule, CD1d. A synthetically derived glycolipid from the marine sponge, <em>Agelas mauritianus</em>, alpha-Galactosylceramide (α-GalCer) potently activates iNK-T cells. Within a few hours after activation, iNK-T …
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SYNTHESIS AND STUDY OF ANTI-TUMOR VACCINES
… weak immune response against carbohydrate antigens has directed several novel approaches towards increasing their immunogenicity for their use as vaccine components. We hypothesized that conjugation of an L-rhamnose (Rha) moiety to a carbohydrate antigen would increase the immune response …
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New Aspects of Alveolar Adaptive Immune Responses in COPD
… in lymphocyte-rich lymphoid aggregates (LAs) and antigen presenting dendritic cells (DCs) in peripheral airways of patients with COPD. These findings suggest that peripheral adaptive immune responses and antigen-driven immune events may contribute to the immunopathology of COPD. However, the …
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INTERNALIZATION AND IMMUNOGENICITY OF MUCOSALLY-ADMINISTERED SOLUBLE AND PARTICULATE ANTIGENS
… thus far, due to several factors such as poor antigen uptake at the mucosal surfaces, lack of immunogenicity of vaccine formulations, and the need for a better understanding of mucosal immune responses. In order to elicit an immune response, mucosal antigens must traverse the epithelium and …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… (AhR). Dendritic cells (DCs), the professional antigen-presenting cells in the immune system, are adversely affected by TCDD. However, limited information exists regarding the effects of AhR activation on DCs. We evaluated the consequences of AhR activation by TCDD on both steady-state and …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… (AhR). Dendritic cells (DCs), the professional antigen-presenting cells in the immune system, are adversely affected by TCDD. However, limited information exists regarding the effects of AhR activation on DCs. We evaluated the consequences of AhR activation by TCDD on both steady-state and …
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Marcatura di molecole biologiche a funzione antigenica per lo studio e la caratterizzazione di protocolli di vaccinoterapia in oncologia medica
… the expression of molecules that enhance antigen capture and selective receptors that guide DCs to and from several sites in the body, where they elicit the T cell mediated immune response. For these features, immature DCs (iDC) loaded with tumor antigen and matured (mDC) with a standard …
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Immunogeneic Cell Populations of the Skin
… type belonging to the sub-group of cells called antigen presenting cells (APCs), inhabit a central role in innate and adaptive immunity. Although the DC family is very heterogeneous, all members share unique features. Most importantly, DCs can stimulate an immune response. This is due to the …