Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"antigen targeting"”.
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Controlled metabolic cell labeling and bioorthogonal click chemistry for cancer targeting
… targeted therapy which I name as Active Tissue Targeting via Anchored ClicK Chemistry (ATTACK), is essentially the small molecule version of antibody/antigen targeting technology and shows multiple advantages. Apart from the efforts in rational chemical designs of azido-sugars, I also developed …
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Engineering immunity : enhancing T Cell vaccines and combination immunotherapies for the treatment of cancer
… for enhancing T cell priming against tumor antigens via covalent modification of molecular vaccines to enhance lymphatic drainage, serum stability, or cytosolic access to improve presentation on MHC class I. In Chapter 4, we demonstrate a combination immunotherapy that recruits a diverse set …
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Efficacy of Dual Cd19-Cd79B Car In B-Cell Malignancies
… with B-cell malignancies relapse following CD19-targeting chimeric antigen receptor (CAR) T cell therapy. CD19 loss is a major cause of relapse and resistance after CD19 CAR T therapy. Dual antigen targeting could overcome resistance due to antigen escape and improve outcomes after CAR T cell …
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Characterizing The Source of Neutrophil Elastase and Proteinase 3 Cross-Presentation In B-Cell Acute Lymphoblastic Leukemia
<p>Discovery of tumor-associated antigens is an important step in designing effective antigen-targeting immunotherapies. PR1 is a nonameric human leukocyte antigen (HLA)-A2 restricted leukemia-associated antigen derived from serine proteases neutrophil elastase (NE) and proteinase 3 (P3). NE and P3 …
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Improving methods for cytokine immunotherapy of cancer
… are not fully ameliorated by attempted tumor targeting. In the first part of this work, we used the B 1 6F 10 melanoma model to demonstrate that a nontoxic dose of IL-2 immunocytokine synergized with tumor-specific antibody to significantly enhance therapeutic outcomes compared to monotherapy …
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Antigen presentation: Influence of Cell Type and Route of Antigen Uptake
… and CD8-DCIR2+ conventional DCs. To examine antigen processing and presentation in vivo, antigens were specifically targeted to CD8+ and CD8- DCs using chimeric monoclonal antibodies. We find that CD8- DCs are better than CD8- DCs for presentation of exogenous antigens onto major …
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B Cell Receptor Signalng in Germinal Centers
… that endocytose, process, and present cognate antigens in proportion to receptor affinity. GCs play a crucial role in immunity by generating an evolving B cell pool that serves as the origin of protective memory B and plasma cells. Therefore, understanding how the GC reaction is controlled and …