Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"antigen processing"”.
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Understanding antigen processing in chickens using genome editing technology
… encode cell surface glycoproteins that present antigenic peptides to T lymphocytes of the immune system. Several other molecules are involved in loading and optimising the peptides for the two major groups of classical MHC molecules, including the transporter associated with antigen processing …
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Novel Mechanisms of Antigen Processing That Enhance Bcg Vaccine Efficacy
… and its proteome to unravel mechanisms of antigen processing and presentation. We initially discovered that three mechanisms of pH regulation including vacuolar proton ATPase, phagocyte oxidase and superoxide dismutase (SOD) secretion from BCG vaccine affect antigen processing within …
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Characterization of antigen processing and presentation by peptide-linked MHC class I molecules
… gewöhnlich Peptide, die aus zytosolischen Antigenproteinen durch proteasomalen Verdau generiert und anschließend vom TAP-Peptidtransporter ins endoplasmatische Retikulum transportiert werden. Es können jedoch auch endozytierte Antigene für die MHC-Klasse-I-vermittelten Antigenpräsentation …
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B Cell Signaling and Bioinformatics: Revealing Components of the MHC Class II Antigen Processing and Presentation Pathway
… revealed a biological process specific to B cell antigen receptor stimulation but not LPS or CD40L stimulation - antigen processing and presentation - and provides the groundwork for new discoveries in this field. As a result, several putative components were identified that are not currently …
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In silico prediction of C57BL/6 mouse T-cell epitopes: enhancing immunogenicity assessment with PREDBL6
The MHC class I antigen processing pathway involves multiple steps: 1) the proteasome selectively cleaves intracellular proteins into short peptides, typically 8–11 amino acids long; 2) TAPs (transporter associated with antigen processing) selectively transport some of these peptides to the …
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Immune-driven positive and balancing selection in human populations
… virus interaction, the innate immune system, and antigen processing and presentation. Results also include variants potentially driving signals of selection. One of these is a missense variant in the Northeast Siberian population in the gene IL27, which is involved in modulation of immune response …
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Kinetics and Intracellular Pathways Required for MHC Ii-Peptide Loading and Surface Expression of a Hapten-Protein Conjugate in Murine Macrophage
Unlike B lymphocytes which recognize antigenic proteins in native form, CD 4+ T lymphocytes recognize fragments of foreign proteins in the context of the major histocompatibility complex class II molecule (MHC II). The sequence of events that lead to the formation of these MHC II-peptide complexes …
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Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells
… expression of the MHC class $\rm I\sb{A}$ antigen processing and presentation pathway and diminished insulin production appear to be distinct pathologic alterations in $\beta$-cells exposed to the insulitic cytokine IFN-$\gamma.$.
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Elucidation of a Macrophage Cell Surface Receptor With Specificity for Exogenous Aromatic Hapten-Protein Antigens and Effects on Antigen Uptake and Processing
… interactions demonstrated that the kinetics of antigen uptake was dependent on the extent of receptor crosslinkage at the cell surface as well as on the accessibility of the ligand groups. Determination of the ligand-binding specificity of the macrophage receptor suggested preference for …
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Processing of Exogenous Hen Egg-White Lysozyme for Presentation on Major Histocompatibility Complex Class I and II Molecules
<p>Exogenous antigen typically enters the major histocompatibility complex: MHC) class II system for processing and presentation to CD4+ T cells. Experiments conducted by Michael Bevan in the 1970s demonstrated that exogenous antigen can also enter the MHC class I system and cross-prime CD8+ T …
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The Major Histocompatibility Complex (MHC) and the proteasome-ubiquitin pathway in T cell development
… development as well as the proteasome role in antigen processing for MHC-mediated antigen presentation to T cells is well established. However, the contribution of nonclassical MHC molecules, the signals evoked by the MHC-TCR interactions, the signaling role of the proteasome-mediated …
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The role of idiotype-specific immunity in antigen receptor diversity
Lymphocytes express antigen receptors which are formed by re-arrangement of gene segments. Mutations acquired during this process, predominantly in the complementarity determining regions (CDRs), result in generation of non-germline sequences. Through analysing the CDR3 sequence, this study …
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Cystatin C and sex dimorphism in experimental autoimmune encephalomyelitis
… protease inhibitor promotes the activation of antigen presenting cells such as macrophages in females that subsequently mediates stimulation of CD4+ T cells. The T cell activation-promoting ability of CysC in female macrophages appears to be related to antigen presentation in macrophages since …
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On the induction of inflammatory reactions by Streptococcus pyogenes
… response. Activation does not require normal antigen processing, it is MHC class II dependent, and V? restricted with preferential expansion of V?2 and 4 bearing T cells, suggesting that M1 protein functions as a superantigen. Thrombin activatable fibrinolysis inhibitor (TAFI) is a human …
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Untersuchung der Genexpression von ABC- und SLC-Transmembranproteinen mit Beteiligung am aktiven Transport von Antigenen, Eikosanoiden und Zytostatika beim malignen Melanom
… (OATP) and transporters associated with antigen processing (TAP). It is presumed that influx transport proteins such as OATP (uptake, phase 0) interact synergistically with metabolizing enzymes such as CYP (biotransformation, phase I and II) and effluxers like MRP (anti-transport, phase …
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LPS from subgingival plaque and the periodontal pathogen Porphyromonas gingivalis, its effect on M1 and M2 macrophage responses and potential as a biomarker
… evasion mechanism through the manipulation of antigen processing and presentation. Proteomic analysis following secondary stimulation (endotoxin tolerisation) suggests that mechanisms which are associated with tolerisation of M1 MΦs and both stimulation and tolerisation of M2 MΦs is due to …
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Investigation of ACE-overexpression in Myeloid Cell Lines through Whole-Proteome Analysis
… including phagocytosis, ROS generation, and antigen processing and presentation were identified whilst metabolic enrichment for TCA, fatty acid oxidation, electron transport chain (ETC) and glucose was present in murine ACE 10/10 macrophages. Human ACE +/+ THP-1 macrophages saw similar ETC, …
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Antigen presentation: Influence of Cell Type and Route of Antigen Uptake
… and CD8-DCIR2+ conventional DCs. To examine antigen processing and presentation in vivo, antigens were specifically targeted to CD8+ and CD8- DCs using chimeric monoclonal antibodies. We find that CD8- DCs are better than CD8- DCs for presentation of exogenous antigens onto major …
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The role of tapasin and its isoforms in antigen presentation and tumor immunity
… (“isoform 1”) plays a critical role in MHC-I antigen presentation by facilitating peptide loading onto MHC-I molecules in the endoplasmic reticulum (ER). This thesis examines the expression, localization and function of two novel, alternatively-spliced isoforms of human tapasin that lack exon …
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Human Chimeric Antigen Receptor Macrophages For Cancer Immunotherapy
Despite recent landmark advances in chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of human cancer, metastatic solid tumors remain an intractable challenge. Myeloid cells are actively recruited to the tumor microenvironment (TME), where tumor associated macrophages (TAMs) …
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