Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"antigen expression"”.
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Control of major histocompatibility Class I antigen expression in adenovirus transformed cells.
… transcription of this gene. MHC class I expression is down-regulated in cells expressing Adenovirus (Ad) 12 E1A compared to cells expressing E1A from Ad2 or Ad5. The possible involvement of these sequences and the factors that bind to them in this down-regulation was investigated using …
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Studies on the genetic basis of Pk, P and P1 blood group antigen expression
… the molecular genetic basis of Pk, P and P1 antigen expression. Sequence analysis of the A4GALT and B3GALNT1 genes proposed to synthesize the related Pk (Gb3) and P (Gb4) antigens, respectively, were performed in p and Pk individuals (n=99) of different geographic/ethnic origin. A total of 24 …
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Molecular characterization of a gene that is associated with Listeria monocytogenes serotype 4b-specific surface antigen expression
… to be involved in serotype-specific surface antigen expression of L. monocytogenes serotype 4b. One mutant, 27B6, derived from L.monocytogenes serotype 4b strain 2381L (Jalisco cheese outbreak), was found to be negative in immunoblot reactions with all three serotype 4b-specific MAbs C74.22, …
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The influence of fixation and cryopreservation of cerebrospinal fluid on antigen expression and cell percentages by flow cytometric analysis
… were comparable. Conversely, loss of marker expression of various lymphocyte sub-populations was observed in Transfixtreated CSF compared to Fresh, and certain cell populations could not be clearly distinguished in Transfix-treated CSF. Conclusion: Cryopreservation is a feasible option for …
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The Regulation of Salmonella Typhi Vi Capsular Antigen Expression in Intestinal Model Epithelia and the Bovine Ligated-Ileal Loop Model
… for the biosynthesis of the Vi-capsular antigen, a significant virulence factor at the focus of developing improved prophylaxis for typhoid fever. Tissue culture experiments have demonstrated that S. Typhi wild-type capsule-expressing strain elicits less chemokine secretion than a viaB …
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A study of activation antigens involved in the pathologicalmechanisms and pathways of cutaneous malignant disease withparticular emphasis on cutaneous T cell lymphoma andmalignant melanoma
… relate to the investigations into AP-1 protein expression in CTCL and melanocyte activation antigens in MM. Results: Findings indicate that expression of AP-1 proteins differs not only according to type of CTCL but also according to stages of tumour progression. In MM activation antigen …
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Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity
… regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination.
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Phenotypic and functional changes in populations of murine macrophages during tumor growth
Four macrophage (Mφ) surface antigens (Ia, Mac-1, -2, and -3) were examined for their association with Mφ regulatory functions. Observations of antigen expression on Mφ derived from normal or tumor-bearing hosts (TBH) showed that changes occurred in the antigen-defined phenotypes of Mφ which evolve …
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Characterisation of weak and null phenotypes in the KEL and JK blood group systems
… investigations of blood samples with aberrant antigen expression as in null and weak phenotypes, or with a phenotype that does not correspond to genotype. With the increasing use of DNA assays based on single nucleotide polymorphisms for blood group prediction, it is important to characterize …
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Studies of the ABO and FORS Histo-Blood Group Systems: Focus on Flow Cytometric and Genetic Analysis
… most important blood group system and its antigens are carbohydrate moieties present on the surface of the red blood cell (RBC) but also on other tissues throughout the body. The ABO gene encodes an enzyme, a glycosyltransferase (GT),that adds a terminal monosaccharide to the precursor …
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Incorporation of tumor antigen epitopes into cytokine signal peptides enhance the efficacy of immuno-gene therapy
… in activating and expanding T cell responses to antigens, cytokines are comprehensively studied for cancer therapy. The efficacy of cancer immunotherapy is diminished by the fact that spontaneous tumors often downregulate antigen expression and/or presentation. The density of tumor antigen in …
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Investigation of T cell-mediated immune surveillance against tumor-specific antigens in genetically engineered mouse models of cancer
… or transgenic mice expressing tumor-associated antigens have been used to model cancer. To assess the role of anti-tumor T cells in models that more accurately reflect the human disease, I developed new systems to introduce exogenous antigens, to mimic neoantigens, into genetically engineered …
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ΑΝΟΣΟΙΣΤΟΧΗΜΙΚΗ ΚΑΙ ΜΟΡΦΟΛΟΓΙΚΗ ΜΕΛΕΤΗ ΤΩΝ ΚΑΡΚΙΝΩΜΑΤΩΝ ΣΤΟΜΑΧΟΥ ΚΑΙ ΕΝΤΕΡΟΥ
… NO SIGNIFICANT CORRELATION WAS FOUND BETWEEN THE EXPRESSION OF THESE ANTIGEN WITH THE TYPE, STAGE OR DEGREE OF DIFFERENTIATION OF TUMORS. THE HIGHER RATE OF HLA-DR ANTIGEN EXPRESSION IN GASTRIC TUMORS AND THE SIGNIFICANT HETEROGENEITY OF EXPRESSION MAYBE IS A CONSEQUENCE OF PHENOTYPIC INSTABILITY …
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Design of novel delivery systems to probe alternative routes of administration for a self-amplifying RNA rabies vaccine
… safer vaccines based on one or few selected antigens. RNA-based vaccines can be engineered to encode any antigen of interest and have the potential for rapid, inexpensive and scalable manufacturing and have an acceptable safety profile. Moreover, they enable in situ antigen expression, …
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Radioimmunotherapy in an Immunocompetent Tumor Model utilizing a 177Lu-mAb
… antibodies that bind to tumor-associated antigens in the tumor, so that the decay of the radionuclide takes place inside the tumor. The aim of the research presented in this thesis was to investigate the effects of RIT (utilizing the radioconjugated antibody 177Lu-BR96) on an inoculated …
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ASSESSING AN M MUTANT VESICULAR STOMATITIS VIRUS FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME BY DETERMINING APOPTOTIC MECHANISMS AND ANTIVIRAL RESPONSE
… analysis demonstrated similar levels of viral antigen expression, but reduced activation of caspase-3 following virus treatment of Bcl-XL-over-expressing tumors compared to controls.
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The design, development and characterization of a self-replicating DNA expression technology
… highly specific T-cell immunity towards targeted antigens, and do not suffer from issues like misdirected vector targeted immunity, like viral based vectors. DNA vaccines, however, face a variety of their own weaknesses. These include, inefficient delivery, high biological loss inside the body, …
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Protein L Functionalized Microparticles For Early Detection of Surface Markers In Heterogeneous Colorectal Lesions
… of the tumor landscape has identified surface antigens that can be utilized to distinguish normal and cancerous tissue lining the colonic lumen. Use of antibodies conjugated to nano/micromaterials offers a means to detect these antigens, however, the heterogeneous nature of tumors makes it …
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