Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"antigen delivery"”.
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Receptor-Mediated Antigen Delivery by Α<Sub>2</Sub>-Macroglobulin: Effect on Cytotoxic T Lymphocyte Immunity and Implications for Vaccine Development
… (α<sub>2</sub>M*) targets antigens (Ag) to professional Ag-presenting cells (APCs) for rapid internalization, processing, and presentation. When employed as an Ag delivery vehicle, α<sub>2</sub>M* amplifies major histocompatibility complex (MHC) class II presentation …
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An evaluation of novel lipid-enveloped nanoparticles for adjuvant and antigen delivery for an HIV vaccine : stepping from laboratory into potential markets
… as synthetic pathogens to deliver HIV specific antigens and adjuvants. The nano-particles are designed to display multiple copies of the antigen on their surfaces and to elicit humoral immunity response. Topics such as patent ability, obtaining an FDA licensure, storage, cost of manufacturing, …
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Synthesis of a hydrogel-based vaccine to mimic dendritic cell responses to pathogens
… to the immunization site, (2) efficient antigen delivery to class I and class II MHC loading pathways coincident with maturation of DCs, and (3) emigration to draining lymph nodes for T cell activation. We have developed a model immunization system designed to allow these steps in the DC …
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An alum particle-based platform to enhance and investigate humoral immune responses to immunization
Slow delivery of vaccines has been shown to amplify humoral immune responses compared to traditional bolus immunization, but clinical translation of frequent repeated immunizations is challenging. In this thesis, we investigate the use of peptide linkers containing consecutive phosphoserine …
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Development of a mucosal vaccine delivery system
Vaccine delivery systems that target the mucosal immune system carry important advantages in terms of accessibility and acceptability. Lipid based nanoparticles with and without the incorporation of bile salts were formulated by novel preparation methods in order to provide suitable immunogen …
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Precision Adjuvant Design Enabling Tailored Nanoparticle Immunization Platforms for Oxycodone and Other Substance Abuse Vaccines
… on judicious adjuvant selection and optimized antigen delivery. This dissertation integrates systematic adjuvant characterization with nanotechnology‑enabled delivery systems to advance a precision‑vaccinology framework targeting oxycodone and related opioids. A comprehensive analysis of …
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Molecular design of nanoparticle-based delivery vehicles for pneumonic plague
… that function as both adjuvants and long-term antigen delivery vehicles in order to improve vaccination, specifically for biodefense-related applications. Chapter 1 is an introduction into the threat of bioterrorism, polymer-based controlled delivery systems and challenges associated with …
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Entwicklung neuartiger bakterieller Vektoren zur Übertragung von zellassoziierten Antigenen, DNA und RNA auf der Basis virulenzattenuierter L. monocytogenes
… ein attraktiver Träger, um heterolog exprimierte Antigene in den MHC-I- und -II-Präsentationsweg antigenpräsentierender Zellen (APC) einzuschleusen und so eine effektive zelluläre Immunreaktion zu erzeugen. Dabei hat die Art und Weise der Antigenexpression einen wesentlichen Einfluss auf die …
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BIOMEDICAL, IMMUNOLOGICALS AND EPIDEMIOLOGICAL STUDIES ON LEISHMANIA
… come sistema di somministrazione mucosale di antigeni ricombinanti, dimostrato mediante il vaccino sperimentale SARS-CoV-2 LeCoVax-2; • Sfruttamento di L. tarentolae come vettore vaccinale mucosale, per esplorarne il potenziale nell’indurre una risposta immunitaria specifica; • Valutazione …