Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"antigen cross-presentation"”.
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Engineering novel antibody-based molecules to probe the role of the immunoglobulin hinge and generate a potential cancer vaccine
… isotypes, the hinge region, which separates the antigen-binding Fab region from the Fc region, varies considerably in length. The hinge region is believed to provide flexibility for the Ig to conduct better positioning for antigen binding via the Fab arms or better receptor association via the Fc …
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Enhancing Chimeric Antigen Receptor T cell therapy in Mouse EGFRvIII Heterogeneous Glioblastoma
<p>Chimeric antigen receptor (CAR) T cell therapy for glioblastoma remains challenging due to insufficient CAR T cell abundance and antigen-negative tumor cells evading targeting. Unfortunately, most preclinical studies evaluating CAR T cells in glioblastoma use tumors expressing a single antigen, …
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MHC Class I Tyrosine Phosphorylation Site Y320 Augments CD8+ T Cell Priming, Effector Function, and Memory Response
… trafficking of H-2K<sup>b</sup> and antigen cross-presentation by dendritic cells (DCs). In this study, we investigated whether there are additional, post-presentation dependencies on Y320 for T-cell priming. We engineered both human- and mouse-derived antigen-presenting cells (APCs) …
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Investigating The Role of Quaking In Antigen Uptake and Cross-Presentation By Dendritic Cells
… cells (DCs) are considered the most potent antigen presenting cells (APC) due to their superior capability of cross-presenting exogenous antigens to CD8<sup>+</sup> T cell for strong adaptive immune responses. They internalize foreign antigens by phagocytosis, endocytosis or …
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The role of a pore-forming protein, Mpeg1, in cytosolic import
Cross-presentation is a process by which professional antigen presenting cells acquire exogenous antigens and present them on their surface on MHC class I molecules. This process is key for the initiation of CD8+ T cell responses. Two main pathways for cross-presentation have been described, …
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Atr-Mediated Cd47 and Pd-L1 Upregulation Restricts Radiotherapy-Induced Immune Priming and Abscopal Responses In Colorectal Cancer
… prime adaptive immunity against tumor-associated antigen (TAA)-expressing CRC cells systemically. However, incidences of abscopal tumor remission are extremely rare, and the post-irradiation immune escape mechanisms in CRC remain elusive. We report that CRC cells utilize a common DNA repair …