Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"antifungals"”.
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DEVELOPMENT OF PROTEIN-BASED ANTIFUNGALS
… limitations facing conventional small molecule antifungals. This thesis aims to explore the relationship between the Pattern Recognition Receptor Dectin1 used by immune cells to recognize the Pathogen Associated Molecular Pattern β-glucan to develop Dectin-1 based biopharmaceuticals against the …
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Antifungals of acromyrmex, allomerus, and tetraponera ant- and cultivarassociated bacteria
… with novel molecular (sub-) structures. Novel antifungals displaying reduced adverse side-effects, increased water-solubilities, and/or strong fungicidal properties would be helpful in medical science for responding to the rising prevalence of human mycoses and for solving problems with adverse …
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The antifungal coating of different wall finishing towards growth inhibition of aspergillus niger
… with the application of three types of antifungals namely potassium sorbate, calcium benzoate and zinc salicylate. The study was conducted to enumerate and evaluate the growth of Aspergillus niger (A. niger). Four different types of wall finishings were utilized; namely acrylic paint, …
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Developing novel drug combinations for treatment of invasive fungal infections
… infections are restricted to three classes of antifungals: Azoles, polyenes, and echinocandins. The emergence of new fungal species, especially C. auris, marked by high resistance profiles and increased mortality rates (30-60%), has further exacerbated the limitations in its therapeutic …
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Endosomal Trafficking as a Determinant of Antifungal Tolerance in the Pathogenic Fungus Candida albicans
… fungal cell membranes. These include the azole antifungals, which block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the accumulation of ‘toxic’ sterol intermediates are both thought to cause plasma membrane dysfunction …
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The Molecular Mechanisms of Antifungal Drug Resistance In Pathogenic Fungi
… individuals. Azoles are the most common antifungals used in treating these infections. The most significant mechanisms of azole resistance include alterations or overexpression of the target enzyme, and overexpression of at least three distinct efflux pumps. Recently, azole-resistant …
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Allylic C—H activation to access anti-1,3-amino alcohol motifs
… molecules including antivirals, antibiotics, antifungals, and various alkaloids. Due to their prevalence and utility as synthetic intermediates, a variety of methods have been developed to access these motifs in a diastereoselective fashion, which are outlined in detail herein. This thesis …
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Transcriptional Regulation of Azole Antifungal Resistance and Tolerance in Candida Glabrata
… rates, treatment failures to the azole class of antifungals, the most widely used antifungal for treatment of C<em>andida </em>infections, have been reported. <em> </em>Contributing to this problem, <em>C. glabrata</em> exhibits intrinsic reduced susceptibility to the azole antifungals, and the …
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Diagnostic characterization of Malassezia pachydermatis isolates from canine otitis externa
… of reduced susceptibility to first-line azole antifungals. Future studies can identify the interaction of these amino acid substitutions with azole antifungals and the genetic determinants of the atypical phenotypes observed for the clinical isolates.
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Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
… virus (HIV). OPC is usually treated with azole antifungals, a class of antifungals that target ergosterol biosynthesis, at low doses over long periods of time. This course of treatment allows for the development of azole resistance.</p> <p>Two major mechanisms of azole resistance exist in C. …
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Evaluating Volatile Organic Compounds for Contact-Independent Antagonism of Pseudogymnoascus destructans and Assessing the Impact of Fungal Pigmentation on Antifungal Susceptibility
… the susceptibility of <em>P. destructans </em>to antifungals. This data emphasizes the role of melanin in virulence, a commonly overlooked factor in the development of WNS control methods, and proposes a new WNS management approach for further investigation and potential field application.</p>
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Evaluating the Fungistatic and Fungicidal Activities of Bianthrones as Synthetic Intermediates to Novel Hypericin Analogues.
… diseases in patients being resistant to previous antifungals. The focus of this research is on the synthesis of anthraquinone, anthrone, bianthrone and hypericin type derivatives and the effect they have on the growth of the yeast species Schizosaccharomyces pombe, Lipomyces starkeyi …
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Synthesis and Antifungal Evaluation of Barbiturate Saponins And Progress Towards Cysteinyl Metal Peptides
… for preparation of novel barbiturate saponin as antifungals and their biological activities would be described. Barbiturates and steroidal saponins have shown remarkable antifungal activity in the biological assays. Therefore, attempts were directed to combine the barbiturate with the steroid to …
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Sexual Reproduction and Signal Transduction in the Candida Species Complex
… to cellular stresses including cations, azole antifungals, and passage through the host bloodstream. First, we show that clinical use of calcineurin inhibitors in combination with azole antifungals does not result in resistance to the combination, suggesting that if non-immunosuppressive …
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Investigating FDA-Approved Drugs for Treatment of Multidrug-Resistant Neisseria gonorrhoeae
… isavuconazole, and ravuconazole, are azole antifungals, and their activities were further investigated in vitro. Of the three azoles, ravuconazole displayed the most potent activity against N. gonorrhoeae clinical isolates. The time-kill assay revealed that the three azoles showed …
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Burning Mouth Syndrome: a demographic and comorbid condition case series
… 50.5% clonazepam, 16.8% topical steroid, 11.6% antifungals, 10.5% maxillary stent, 10.5% membrane stabilizer Rx, 7.4% Sialogogue, and 4.2% for behavior modification, capsaicin, and stress reduction. Comorbid Conditions: Xerostomia 35.8%, Candida 21.1%, Bad Taste 29.5%, Post-menopausal 72.6%, …
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Examining How Non-Antifungal Medications Impact Host-Fungal Interactions
… synthase. However, despite multiple classes of antifungals available to treat invasive candidiasis, treatment failure rates are alarmingly high, being approximately 30%. Certainly, the increasing incidence of acquired drug resistance, as well as the emergence of species with intrinsic resistance …
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Signal Transduction and Transcriptional Regulation Pathways Essential for Azole Resistance in Candida albicans
… human immunodeficiency virus (HIV). The azole antifungals (such as fluconazole) are the most widely used and important ergosterol biosynthesis inhibitors (EBIs) for the treatment of Candida infections, including OPC. However, the azoles are fungistatic against C. albicans and therefore have …
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Comparative study on indoor fungi growth incorporated with different antifungal and wall finishings
… growth of indoor fungal by using three different antifungals such as potassium sorbate, zinc salicylate and calcium benzoate. The indoor fungi were isolated from selected room at Faculty of Civil and Environmental Engineering (FKAAS). The objective is to enumerate the growth of indoor fungal after …
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Loss of the SAC Components SldA Kinase or SldB or in vitro Adaptation to Triazole Produces Aneuploidy Associated with Triazole Heteroresistance in Aspergillus fumigatus
… survives and adapts to medical triazole antifungals.</p>
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