Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"antifungal therapies"”.
-
The Thiol Specific Antioxidant (TSA1) Gene is Required for Survival in Macrophages and Oxidative Stress Resistance in Histoplasma Capsulatum
… system is critical to development of targeted antifungal therapies.</p>
-
Development of novel polymeric microneedle systems for long-acting intradermal delivery of poorly soluble compounds
… taken into in vitro release studies and also antifungal examinations. In vivo studies were performed to demonstrate the long-acting effects and systemic exposure of the chosen formulations. This thesis provides significant evidence regarding the successful localised and long-acting delivery of …
-
Probing the role of histone acetylation in the evolution of pathogenicity in <i>Candida glabrata</i>
… challenges due to the former’s intrinsic antifungal resistance. <i>C. glabrata </i>also possesses a particularly interesting phylogeny, being a pathogen that is closely related to the non-pathogenic yeast <i>S. cerevisiae</i>. This makes <i>C. glabrata</i> a valuable model species to …
-
Targeting Coenzyme A Biosynthesis for Antifungal Development.
… limited by the modest efficacy of the available antifungal drugs: the azoles, echinocandins, and amphotericin B. Approximately one-third of patients with disseminated Candida infections are non-responsive to treatment with the azoles, and favorable response rates are just 52-73% for the …
-
Sexual Reproduction and Signal Transduction in the Candida Species Complex
… Despite increases in drug resistance, the antifungal armamentarium has changed little over the past decade. Thus increasing our understanding of the life cycles of these organisms, not only how they propagate themselves, but also how genetic diversity is created within the population is of …