Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"antifungal drug target"”.
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Experimental and computational methods for identification of novel fungal histone acetyltransferase Rtt109 inhibitors
… H3 lysine 56 acetylation and is a promising antifungal drug target. To identify novel Rtt109 inhibitors as potential drug scaffolds, we employed in vitro high throughput screening (HTS) and various computer-assisted strategies, including molecular dynamics, docking, three-dimensional …
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Peering into Candida albicans pir protein function
… of study because the cell wall is an important antifungal drug target. Pir proteins (proteins with internal repeats), which are linked to β-1,3-glucan in the cell wall, were characterized initially in Saccharomyces cerevisiae, then detected in other fungal species. Despite extensive work in S. …
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Functions of RNA exosome and tRNA splicing ligase in Mendelian and Infectious diseases
… cause various Mendelian diseases, while drugs that inhibit pathogen-specific RNA processing enzymes promise to be effective treatment options for infectious diseases. The RNA exosome complex is a major 3’ RNase in eukaryotes that catalyzes the processing and degradation of a wide range of …