Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"antiestrogen resistance"”.
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Altered estrogen receptor and transforming growth factor pathways in models of estrogen-autonomous and of antiestrogen-resistant MCF-7 human breast cancer cells
… of breast tumors to steroid-autonomous and antiestrogen-resistant phenotypes confounds our ability to treat breast cancer with antiestrogens, the most efficacious hormone treatment used clinically. We developed two models in the MCF-7 cell line, an estrogen receptor-positive human breast …
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The anticipatory unfolded protein response and estrogen receptor mutations in breast cancer
… E2:ERα activity often leads to development of antiestrogen resistance. Approximately 30% of patients who have metastatic endocrine therapy resistant breast cancer express ERα mutations. Two of the most common and therefore widely studied mutations are ERαY537S and ERαD538G. Patients whose …
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From network to pathway: integrative network analysis of genomic data
… an understanding of the molecular mechanisms of antiestrogen resistance in breast cancer. Finally, we conclude this dissertation with a summary of the original contributions, and the future work for deepening the theoretical justification of the proposed methods and broadening their potential …
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Mechanismen der Durchbrechung der sekundären Antiöstrogenresistenz durch GnRH-Analoga in Mammakarzinomzellen
Bei der Therapie des Östrogenrezeptor-positiven Mammakarzinoms stellt die Entwicklung einer Resistenz gegenüber der antiproliferativen und proapoptotischen Wirkung des Antiöstrogens Tamoxifen ein großes Problem dar. Die Aktivierung verschiedener Signaltransduktionskaskaden von …