Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"antiepileptic drugs"”.
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The reduction of tolerance to the anticonvulsant effects of antiepileptic drugs
… to the anticonvulsant effects of many different antiepileptic drugs. In some cases, tolerance to antiepileptic drug effects is so complete that the drugs become clinically ineffective, even at toxic doses. This is clearly problematic for the treatment of epilepsy. The purpose of this thesis was …
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Treatment patterns of antiepileptic drugs and economic outcomes in patients with potential refractory epilepsy in the Texas Medicaid Program
… years of age, 2) had a prescription claim for an antiepileptic drug (AED) during the identification period (03/01/08-12/31/11) with no baseline use of an AED and no prophylactic use of an AED at follow-up, and 3) had evidence of epilepsy diagnosis during the study period. Additionally, patients …
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Characterization and application of human pluripotent stem cell-derived neurons to evaluate the risk of developmental neurotoxicity with antiepileptic drugs in vitro
… voltage- and ligand-gated ion channels. Antiepileptic drugs (AEDs) are associated with developmental neurotoxicity. These agents can cause congenital malformations, cognitive deficits and behavioral impairment in children as a result of in utero exposure. The impact of four major AEDs, …
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Synthesis of 3-Aryl-2-(2-aryl-2-oxoethyl)pyrido[2,3-d]-4(3H)pyrimidones and 3-Aryl-2-(2-arylethenyl)pyrido[2,3-d]-4(3H)pyrimidones as Potential Antiepileptic Drugs
… were synthesized for testing as potential antiepileptic drugs. The goal was to achieve better neurological activity and/or lower toxicity than displayed by a series of 2-alkyl-3-aryl-4(3H)-quinazolinones prepared previously in our research group. From the pharmacological testing data of …
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Canais iônicos na epilepsia : aspectos fisiopatológicos e terapêuticos
… clinic manifestation of epilepsy. The antiepileptic drugs act on multiple molecular targets modulating the activity of voltage-sensitive ion channels (Na+ and Ca2+ channel inhibitors and K+ channel activators), increasing GABAA receptors-mediated neuronal inhibition (GABAergic …
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Meta-analysis of the population and phenotypic expression of CYP2C9/2C19 polymorphism on drug metabolism in different ethnicities
… has been investigated; although many new antiepileptic drugs have been launched into the market, carbamazepine, phenobarbital and phenytoin are still the major agents in the pharmacotherapy of epilepsy. Therefore, phenytoin was chosen as a model AED and the effect of CYP2C9/2C19 genetic …
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Parent-Reported Anxiety in Children with Secondary Generalized Seizures
… EEG findings, MRI findings, number of antiepileptic drugs prescribed, side-effect profile of medication, and therapy regimen, were reviewed as well as parent-reported anxiety and depression on the Behavior Assessment System for Children, Second Edition (BASC-2). Findings of the current …
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Design and testing of wearable and long-term subdermal implantable electroencephalograms
… is especially important given the severity of antiepileptic drugs' side-effects. The performance of this device is verified through animal studies in pigs. This work is also extended to the design of a wearable, wireless EEG patch for sleep studies. The device is a 20mm x 24mm, 4-channel, 250Hz …
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Observational and Experimental Studies on the Diagnosis and Outcome of Epilepsy and Epileptogenic Conditions: Investigating the Static and Dynamic Phenotype of Epilepsy
… epilepsy (DRE) with reference to the number of antiepileptic drugs (AEDs). In 1/3 of cases a confident diagnosis of PNES/ES can be established by epileptologists on video data only. Compared to epileptologists, psychiatrists demonstrated to be less accurate in diagnosing PNES but more attuned to …
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The Effects of Seizure Modeling and Polyphenols on Behavior in Bang-Sensitive Drosophila
… and psychosocial consequences. Current antiepileptic drugs can have debilitating side effects and new treatments are needed for individuals with pharmaco-resistant seizures like those observed in temporal lobe epilepsy (TLE). Ellagic acid (EA), a polyphenol present in several fruits and …
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Propagation of generalised discharges in idiopathic generalised epilepsy
… discharges and good response to prescribed antiepileptic drugs (AED), and between non-synchronous discharges and poor response to AEDs (p=0.0001). The proportion of patients who responded favourably to medical treatment was significantly higher among those with synchronous discharges (>80 %) …
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Metabotropic glutamate receptors as targets for antiepileptic drug therapy: a behavioral and electroencephalographic analysis
… rates of up to 40%. Classically, targets for antiepileptic drugs have included glutamatergic ion channels. However, interfering with excitatory signalling at these channels can alter normal neural communication and can have negative side effects, including cognitive dysfunction and fatigue, …
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Long-term, subdermal implantable EEG recording and seizure detection
… is especially important given the severity of antiepileptic drugs' side-effects. An ASIC that implements the EEG recording and seizure detection algorithm was designed and fabricated in a 0.18 [mu]m CMOS process. The ASIC includes eight EEG channels and was designed to minimize the system's …
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Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development
Many antiepileptic drugs on the market, including valproic acid (VPA), have a wide range of therapeutic effects in addition to treating epilepsy. In recent years, the use of VPA in the treatment of psychiatric conditions has been on the rise. However, studies have shown that in utero exposure to …
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Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides
Intractable seizures and lack of effective antiepileptic drugs (AED) are severe and common conditions affecting many patients with epilepsy. Thus, there is an urgent need to develop new therapies in epilepsy. The search for novel treatments has identified several neuropeptide systems as potential …
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The Risk of Seizure Recurrence Following a First Unprovoked Seizure in Childhood: An Extended Follow-Up
… variable. Untoward effects of long-term AEDs(antiepileptic drugs), especially cognitive dysfunction and behavioral problems, are important especially in developing children. For these reasons, informations with regard to the recurrence rate following a first unprovoked seizure and the …
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The investigation of pathophysiological mechanisms underlying KV7-related epilepsy and neurodevelopmental delay
… EE is often associated with poor response to antiepileptic drugs (AEDs), whereas both EE and NDD patients display progressive loss of cognitive and behavioral functions over time. While extensive studies have focused on BFNE mutations, the pathogenetic mechanism underlying EE and NDD variants …
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Anterior temporal lobectomy. A cross-sectional observational study of potential surgical candidates at a single institute
… human focal epilepsy. It is often refractory to antiepileptic drugs, and the most amenable to surgical treatment which often renders patients seizure free. Furthermore, surgery for mTLE has low procedural risk, is cost-effective and best performed early in the disease course for maximal benefit. …
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The gut-brain axis in seizure susceptibility: A role for microbial metabolite S-equol
… However, in both adults and neonates, current antiepileptic drugs (AEDs) are ineffective in 30-50% of patients, despite the availability of over 20 FDA approved AEDs with diverse molecular targets. This disparity highlights a critical need for novel therapeutics in seizure-susceptibility and …
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Sleep Disturbances in Adults with TSC: Influences of Treatment and Clinical Features
… Those who self-reported taking mTOR inhibitors, antiepileptic drugs, or antidepressants were also more likely to have severe sleep problems (<em>p</em><sub>AD</sub>=0.016, <em>p</em><sub>mTORi</sub><0.001, <em>p</em><sub>AEDs</sub>=0.045). Epilepsy was not found to be a risk factor for an …
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