Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"antidepressant therapies"”.
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PET-imaging in depression and antidepressant therapies : focus on the serotonin system and the cerebral glucose metabolism
… of the serotonin transporter in depression and antidepressant therapies. Hereby, several studies were performed using the PET radiotracer [11C]DASB, which specifically targets the serotonin transporter. To allow qualitative and safe research with this radiotracer, the first research topic …
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Management of treatment resistant depression /
… often do not respond adequately to standard antidepressant therapies. This dissertation provides a narrative review of current literature on Treatment-Resistant Depression, with a focus on exploring treatment options, assessing their efficacy, and highlighting limitations. Pharmacological …
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Investigations of Serotonin Metabolism in Mammalian and Other Deuterostome Model Systems
… levels often associated with a combination of antidepressant therapies. This research contributes to our understanding of the metabolic pathways of 5-HT in both healthy and disease states. The findings aid in understanding the 5-HT link to various disorders.
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Optimizing Treatment for Depression: Integrating TMS and Ketamine Through Provider and Clinical Staff Education
… (MDD) and often do not respond to traditional antidepressant therapies, thus leading to a need for other modalities. Novice treatments for TRD include ketamine, an NMDA receptor antagonist, and TMS, a non-invasive brain stimulation technique, both of which have demonstrated effectiveness. …
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An In Vitro Characterization of the Raphe Nucleus and the Effects of SSRIs on Synaptic Neurotransmission
Antidepressants are traditionally used in the treatment of depression. While these drugs rapidly inhibit the reuptake of neurotransmitters in the synaptic terminal by blocking the serotonin and norepinephrine transporters, clinical efficacy can take several weeks. This phenomenon implies that …
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Cell Type Specific Roles of Serotonin Receptor 4 in the Hippocampus and Neocortex in Emotion and Cognition
… the need for faster acting and more efficacious therapies. Preclinical studies indicate a critical role for Serotonin Receptor 4 (5-HT<sub>4</sub>R, product of the Htr4 gene) in this direction as drugs that activate this receptor show fast-acting antidepressant-like properties. Unfortunately, …
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Characterization of the Roman lines/strains of rats as a genetic model of psychiatric disorders: a behavioral and brain dialysis study
… In addition, pharmacological and psychological antidepressant therapies in use have a limited efficacy and/or are associated with side effects that reduce the compliance in many patients. Although the etiology and pathogenesis of depression are poorly understood, it is most likely that the …