Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"antidepressant effect"”.
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Antidepressant effect of pramipexole in a dexamethasone induced depressive-like behavior model
Resumo: A depressão é um distúrbio psiquiátrico comum caracterizado por diversos sintomas debilitantes como a desesperança e a anedonia. Apesar de a fisiopatologia do distúrbio ainda não estar completamente elucidada, evidências demonstram a associação entre a depressão e disfunções do sistema …
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Translational Regulation in Excitatory Neurons Controls Stress Reactivity and the Antidepressant Response to Ketamine
… axis activation. Ketamine produces rapid antidepressant effects, partly through mammalian target of rapamycin complex 1 (mTORC1) signalling, which phosphorylates 4E-Binding Protein 1 and 2 (4E-BPs) to promote synaptic plasticity. This thesis examines the role of 4E-BP signalling in …
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Alternative interventions for young men's mental health
The main aim of this thesis was to explore the effectiveness and acceptability of alternative interventions for facilitating help-seeking and improving the mental health of young adult males. Based on recommendations for innovative ways to develop interventions that facilitate mental health …
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The crucial role of reelin in a preclinical model of depression
… (FST). In the second experiment, the potential antidepressant effect of reelin (at either 3μg or 5μg either every 5 or 10 days) via lateral tail vein injections on depressive-like behaviour and reelin expression in the SGZ was assessed in the CORT model, and the correlation between reelin …
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The design, synthesis, and biological evaluation of aplysinopsin analogs as potential neuromodulators
… their in vivo efficacy. Compound 33 shoa modest antidepressant effect at a dose of 30 nM/kg in the animal model. In an effort to improve the in vivo efficacy of aplysinopsin analogs, we used an in silico ADME predictor (QikProp) to evaluate and design a new series of analogs with improved ADME …
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Caratterizzazione del clofibrato agonista sintetico dei recettori dei proliferatori dei perossisomi (PPARα)in modelli animali di depressione ed ansia
… have been published on PPARα mediated behavioral effects, which suggests that PEA exerts anxiolytic and antidepressant-like effect in mice (Crupi et al., 2013, Yu et al., 2011). However no studies have been evaluated antidepressant-like effect of synthetic PPARα agonists. Thus, the aim of our …
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Dissociated Antidepressant and Analgesic Effects of Intravenous Ketamine in Patients with Chronic Pain
연구 배경: 최근 연구들은 저용량의 케타민 치료가 수시간 혹은 수일 안에 우울 증상을 유의하게 호전시켰음을 증명해 왔다. 본 연구는 만성 통증 환자에서 케타민이 기분에 미치는 효과를 알아보고자 시행되었다. 연구 방법: 2013년 1월, 단일 기관에서 케타민 치료를 받는 통증클리닉 외래 환자 40명이 설문에 응하였다. The Beck Depression Inventory (BDI) 가 각 대상자의 기분을 평가하기 위해 사용되었고, 이후 케타민이 1시간에 걸쳐 모든 대상자에게 정맥 투여되었다 (평균 1.2mg/kg). 우울, 불안, …