Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"anticonvulsants"”.
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The role of the cholinergic system in the anticonvulsant effects of the barbiturates and other anticonvulsants
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The newer anticonvulsants in the treatment of generalised anxiety disorder: a systematic review and meta-analysis
… efficacious GAD medication. It has hypothesised anticonvulsants possess anxiolytic properties based on animal studies and epilepsy trials. There is inconsistent evidence that anticonvulsants are efficacious in GAD. It was considered useful and timely to investigate this further. The newer …
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The Design and Synthesis of Novel Barbiturates of Pharmaceutical Interest
… uses as anxiolytics, sedatives, hypnotics, and anticonvulsants. Recent investigations of barbituric acid derivatives have provided scientists with information that barbituric acids may have applications in antibacterial, anti-chlamydial, anti-viral, as well as anti-cancer treatments. …
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Induced hypothermia after cardiac arrest
… common, but only sustained hyperglycaemia and anticonvulsants administered for seizures were associated with increased mortality. Bleeding and infections were more common for patients having invasive procedures performed, but these adverse events were not associated with increased mortality. In …
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The synthesis and pharmacology of novel excitatory amino acid mimetics
… (APH) acids are very potent NMDA antagonists and anticonvulsants and in order to further the pharmacological study of this class of compound, efficient synthetic routes have been developed which afford the compounds in high overall yields. APB(2-amino-4-phosphono-butanoic acid), APP and APH can …
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Studies in the handling and absorption of biopterin derivatives in man
… controls were found in cirrhosis, epileptics on anticonvulsants, treated Parkinsons disease and carcinoma. The last group was small in number. Significantly low urine levels were found in rheumatoid arthritis and controlled epilepsy but not in schizophrenia. Urinary concentrations of Crithidia …
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An evaluation of the use and efficacy of analgesics in the management of chronic pain in the community.
… Use of other therapies for pain e.g. anticonvulsants, hypnotics and herbal products was significantly higher in RA patients. Documentation of biochemical and haematological parameters in GP records was very limited. Twenty-eight patients had poor outcomes requiring GP referral, but …
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Synthesis of 3-Aryl-2-(2-aryl-2-oxoethyl)pyrido[2,3-d]-4(3H)pyrimidones and 3-Aryl-2-(2-arylethenyl)pyrido[2,3-d]-4(3H)pyrimidones as Potential Antiepileptic Drugs
A series of 2-alkyl-3-arylpyrido[2,3-d]pyrimidones were synthesized for testing as potential antiepileptic drugs. The goal was to achieve better neurological activity and/or lower toxicity than displayed by a series of 2-alkyl-3-aryl-4(3H)-quinazolinones prepared previously in our research group. …
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Characterising the functional homology of central nervous system drug targets in larval zebrafish (Danio rerio)
… and environmentally relevant compounds: three anticonvulsants (carbamazepine, lamotrigine, gabapentin), three antidepressants (venlafaxine, escitalopram, trazodone), and three antipsychotics (aripiprazole, clozapine, risperidone). Chapter 1 reviews the occurrence, mechanisms of action, and …
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Oxidative Treatment of Emerging Micropollutants and Viral Pathogens by Potassium Permanganate and Ferrate: Kinetics and Mechanisms
… active compounds (PhACs), including antibiotics, anticonvulsants, painkillers, estrogenic hormones, lipid regulators, beta-blockers, antihistamines, X-ray contrast media, etc., in drinking water sources has been reported in recent years. The presence of these contaminants, although at low …
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Die Wirkung von Antikonvulsiva auf ATP-sensitive Kalium-Kanäle
Das Antikonvulsivum Gabapentin (Neurontin) zeigt bei der Behandlung von fokalen und se-kundär generalisierten tonisch-klonischen epileptischen Anfällen als Zusatztherapeutikum und seit jüngster Zeit auch als Monotherapeutikum eine gute Wirkung. Auch in der Schmerztherapie, wie etwa bei der …
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Removal of Organic Micro-Pollutants from Water Using Sewage Sludge Based Composite Adsorbents
… properties of the analytes. The two anticonvulsants did not experience significant signal changes when mixed with NOM, whereas all 11 antibiotics experienced some signal supersession when mixed with one or more of the NOM. Possible mechanisms leading to the signal suppression include …
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Regulation Of Inositol Biosynthesis And Cellular Consequences Of Inositol Depletion: Implications For The Mechanism Of Action Of Valproate
<p>Inositol is a six-carbon cyclitol that is ubiquitous in biological systems. It is a precursor for the synthesis of numerous biologically important compounds, including inositol phosphates and phosphoinositides that are essential for cell function and viability. Inositol compounds play a role in …
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Pharmacotherapy for Social Anxiety Disorder and Posttraumatic Stress Disorder: New Meta-Analytic Approaches to Synthesising the Evidence
… with evidence of a treatment response for anticonvulsants with gamma-amino butyric acid (GABA) analogues, the MAOIs, the RIMAs and the benzodiazepines. For the treatment of PTSD, the alpha-blocker prazosin and antipsychotics reduced symptom severity, and the alpha-blocker prazosin and the …
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The Effects of Seizure Modeling and Polyphenols on Behavior in Bang-Sensitive Drosophila
<p>Epilepsy is a worldwide public health concern associated with debilitating neurological, cognitive, and psychosocial consequences. Current antiepileptic drugs can have debilitating side effects and new treatments are needed for individuals with pharmaco-resistant seizures like those observed in …