Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 33 for “"anticonvulsant"”.
-
Anticonvulsant drugs in immunosuppression and carcinogenesis / by Tania C. Sorrell
[20] 172 [45] leaves
-
The reduction of tolerance to the anticonvulsant effects of antiepileptic drugs
Tolerance has been shown to develop to the anticonvulsant effects of many different antiepileptic drugs. In some cases, tolerance to antiepileptic drug effects is so complete that the drugs become clinically ineffective, even at toxic doses. This is clearly problematic for the treatment of …
-
Anticonvulsant effects of PPAR-gamma activation in an in vitro model of seizure
… seizure models suggest PPARγ agonists have anticonvulsant efficacy. These results, however, need to be replicated at a more concentrated level to understand tissue-specific effects. Thus, we performed extracellular electrophysiological experiments with a PPARγ agonist (pioglitazone) and an …
-
A combinatorial approach to the search for anticonvulsant agents from gou teng and tian ma
… the new synthesized 2-oxindole derivatives. The anticonvulsant and neuroprotective activity were tested on mice inflicted by maximal-electroshock (MES) and neuronal cells insulted by neurotoxins. The results showed that neither of the herbal extracts could protect mice from MES induced seizures, …
-
The role of the cholinergic system in the anticonvulsant effects of the barbiturates and other anticonvulsants
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Synthesis of 3-Aryl-2-(2-aryl-2-oxoethyl)pyrido[2,3-d]-4(3H)pyrimidones and 3-Aryl-2-(2-arylethenyl)pyrido[2,3-d]-4(3H)pyrimidones as Potential Antiepileptic Drugs
… of the quinazolinone framework increased the anticonvulsant activity. However, the neurological toxicity increased as well. The anticonvulsant and neurotoxic activity seen in the variuos 2-alkyl side chains and 3-aryl substituents incorporated into these new pyridopyrimidones was consistent …
-
Investigating excitatory GABAergic signalling & benzodiazepine resistance in an in vitro model of status epilepticus
… contributes to SE, nor how it may modulate the anticonvulsant properties of benzodiazepines. In this thesis I explore the role of excitatory GABAergic signaling in an in vitro model of SE and how this may affect the anticonvulsant efficacy of the benzodiazepine, diazepam. Firstly, I confirm that …
-
The newer anticonvulsants in the treatment of generalised anxiety disorder: a systematic review and meta-analysis
… efficacious GAD medication. It has hypothesised anticonvulsants possess anxiolytic properties based on animal studies and epilepsy trials. There is inconsistent evidence that anticonvulsants are efficacious in GAD. It was considered useful and timely to investigate this further. The newer …
-
Discriminative Stimulus Effects of Gabapentin
… the discriminative stimulus effects of the anticonvulsant gabapentin in rats trained to discriminate 30.0 mg/kg gabapentin from vehicle in a two-lever drug discrimination task. All of the ten rats tested were able to establish gabapentin as an interoceptive cue. Gabapentin produced full …
-
Functional Redistribution of Hippocampal Cannabinoid Cb1 Receptors in the Rat Pilocarpine Model of Acquired Epilepsy
… Δ9-THC, are known to have CBl receptor-mediated anticonvulsant effects in several animal models of seizures and epilepsy, including the rat pilocarpine model of acquired epilepsy. However, the distribution of CBl receptor expression and function in brains of epileptic rats has not been …
-
The Effects of Seizure Modeling and Polyphenols on Behavior in Bang-Sensitive Drosophila
… (bss) and easily shocked (eas)], 2) explore the anticonvulsant effects of EA, and 3) investigate EA’s mechanism of action through the addition of two types of GABA antagonists: flumazenil (FL) and picrotoxin (PTX). The results indicated that vortexing consistently induced seizure-like activity …
-
Studies of intramolecular S<sub>RN</sub>1 reactions of carbanions derived from 2-(o-halobenzyl)amides and 3-(o-halobenzyl)imides: application to the synthesis of succinimido[3,4-b]indane, a potential anticonvulsant
… that might be useful in the development of new anticonvulsant agents. In this context, the preparation of succinimido[3,4-b]indane (61), which seemed likely to possess antiepileptic properties, fulfilled our proposed objective of applying novel chemistry to the preparation of a new potential …
-
Molecular orbital calculations of the activities of a series of CNS drugs
… which examine the compounds' sedative and anticonvulsant activities. Each type of biological data was used to seek correlations with the molecular orbital. indices. Useful equations were calculated for six of the biological tests; these may prove to be useful for the prediction of new …
-
Indagine etnofarmacologica su Casimiroa edulis Llave et Lex
… hypnotic-sedative, anticataleptic, anticonvulsant, antinociceptive and antinflammatory activities. The results revealed that the extract of seeds reduced spontaneous motor activity and rearing; in the forced swimming test (FST) it caused a potent sedative effect; in the test of …
-
Diverse roles of cyclooxygenase in the central nervous system and the periphery
… seizure susceptibility, and PGF2α act as anticonvulsant in neonatal brain. In present study, mouse neonate (post-natal day 9; P9) are far more prone to KA-induced seizures than the adult (P35). The seizure activities in the adult, which were aggravated by COX inhibition, showed less than …
-
The role of folic acid supplementation on exencephaly induced by maternal exposure to sodium valproate in the TO mouse
Valproic acid (WA) is an anticonvulsant drug known to cause spina bifida in humans and exencephaly in animals. The Theiler Outbred (TO) mouse exhibits a low incidence (4.4%) of spontaneous exencephaly at birth. This frequency is enhanced by sodium valproate (VPA), an anticonvulsant drug. Earlier …
-
Gabapentin Discriminative Stimulus Effects
<p>Gabapentin (Neurontin®), an anticonvulsant drug, is primarily prescribed for neuropathic pain and epileptic seizures. Gabapentin is an inhibitor of the voltage gated calcium channel (VGCC) subunit α<sub>2</sub>δ-1. Due to its unique binding site, gabapentin is widely thought to have low abuse …
-
Role of Endogenous Prostaglandins on Kainic Acid Induced Seizure Activity
… through PGF2α might act as endogenous anticonvulsant through FP receptors.
Page 1 of 2