Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"anticoagulant"”.
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The impact of a direct oral anticoagulant in cardiovascular disease
Novel oral anticoagulants (NOACs) have uncomplicated dosing with no need for INR monitoring and fewer possible drug and food interactions compared to warfarin, which may result in improved adherence to treatment and may offset the high retail cost of NOACs. Rivaroxaban 10mg is the only NOAC …
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Assessing the effects of anticoagulant rodenticides on non-target fish species
… can leads to restoration of native ecosystems. Anticoagulant rodenticides (ARs) have been an effective tool for rat eradication on many oceanic island systems (Wilmer et al 2007). The Hawaiian Islands, USA have used first generation AR, diphacinone (DPN), for pest and rodent control. Rodent …
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Advancing sepsis treatment: synthesis and evaluation of multi-target drugs with antimicrobial, antioxidant and anticoagulant properties.
… lysis assay was performed to investigate the anticoagulant properties. Compounds JW1, JW4, JW9 and JW11 demonstrated the strongest fibrinolytic activity, achieving a 50% clot lysis time of 68-78 minutes compared to the control (Pooled Normal Plasma + Phospholipids + tPA), which had a 50% clot …
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Anticoagulant Treatment Effects Assessment in Antiphospholipid Syndrome Patients Using Targeted Learning and the Oracle Health EHR Data
… While warfarin has traditionally been the go-to anticoagulant for most patients with APS, many clinicians are now turning to direct oral anticoagulants (DOACs). However, there's still a lot of uncertainty about how effective these newer medications are compared to warfarin, especially for …
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Integrating LLMs and Causal Inference: Comparing Oral Anticoagulant Effects on Thrombosis Recurrence, Bleeding Risk and Death Using MIMIC-IV Data
<p>Many clinically important variables are found only in medical notes, leaving gaps for prediction and confounding adjustment. We analyzed medical discharge notes for acute-thrombosis admissions in MIMIC-IV. Privacy was preserved by generating synthetic medical notes that mirror the content and …
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RECYCLING OF WASTE BLOOD INTO FUNCTIONAL CARBON NANOPARTICLES
… blood waste management and explores alternative anticoagulant therapies. Through a hydrothermal process, optimal conditions for HD synthesis were identified at 230°C for 10 minutes, maximizing fluorescence intensity and carbon nanoparticle quality. Characterization confirmed HDs’ carbon-based …
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The Chelating Effect of 5-(p-Acetoxy-Phenyl)-4,6 Dicarbethoxy Cyclohexanedione-1,3 on the Calcium Concentration of Human Blood Serum: Also the Anticoagulant Effect of the Above Compound
… time or prothrombine time and thus serve as an anticoagulant. Toxicity is also to be observed. Derivatives of the above compound are used, because the parent compound is insoluble in water.
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Incidence of adverse drug events in COVID-19 patients on anticoagulants: a pharmacovigilance study
… to the use of the drug heparin, a widely used anticoagulant. The main objective of this study was to assess whether there were any adverse events associated with the administration of anticoagulants in patients known to have COVID-19. Thus, it was hypothesized that with study of different …
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ΑΝΑΣΤΟΛΕΙΣ ΤΥΠΟΥ "ΑΝΤΙΠΡΟΘΡΟΜΒΙΝΑΣΗ". ΚΛΙΝΙΚΟΕΡΓΑΣΤΗΡΙΑΚΗ ΜΕΛΕΤΗ
THE LUPUS ANTICOAGULANT WAS DETECTED IN THE PLASMA OF 44 ADULTS DURING A 6-YEAR-PERIOD AT THE CENTRAL LABORATORY OF HEMOSTASIS IN THE HOSPITAL HENRI MENDER (FRANCE). THE CONSIDERABLE NUMBER OF PATIENTS AND THEIR NON-SELECTIVE RECRUITEMENT HAS PERMITTED TO DRAW VALUABLE CONCLUSIONS FROM CAREFUL …
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A comparative study of ROTEM-EXTEM results obtained from EDTA-treated whole blood samples and Sodium Citrate-treated whole blood samples in healthy volunteers
Background: A number of anticoagulants are available in clinical use to preserve blood samples in liquid form until a suitable time for laboratory testing. Rotational thromboelastography is usually performed on a blood sample that has been anticoagulated with sodium citrate and then recalcified …
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Increasing Patient Satisfaction and Decreasing Hospital Readmission Due to Deep Venous Thrombosis by Providing Anticoagulation Education for Orthopedic Patients
<p>Abstract</p> <p>Improving Process on Oral Anticoagulant Education for Orthopedic Patients</p> <p>The aim of this project is to improve anticoagulation education for orthopedic patients to increase patient satisfaction. The microsystem for this project is a medical-surgical (MS), 50-bed unit in a …
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Stroke risk factors, outcomes and models of stroke care in a culturally and linguistically Diverse (CALD) elderly population.
… be suboptimal in elderly patients. For example, anticoagulant therapy for stroke prevention in patients with atrial fibrillation was underused, particularly in NESB patients (Chapter 2). The reasons for under-usage of anticoagulant therapy were investigated in a general practitioner survey …
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Validation of Criteria Used to Predict Warfarin Dosing Decisions
… at risk for blood clots are often treated with anticoagulants, warfarin is such an anticoagulant. The dose's effect is measured by comparing the time for blood to clot to a control time called an INR value. Previous anticoagulant studies have addressed agreement between fingerstick (POC) devices …
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Biochemical Evaluation of Lignin-like Molecules
<p>Current anticoagulants carry a serious risk of bleeding complications. In addition, narrow therapeutic index, drug interactions, immunological reactions, toxicity and high cost to benefit ratio limits the effective use of these drugs in patients with thrombotic conditions.Heparin is the most …
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Designing Allosteric Inhibitors of Thrombin
… anti-coagulation processes. Most clinically used anticoagulant drugs, including polymeric heparin, warfarin, hirudin, argatroban and the recently approved dabigatran, aim to reduce thrombin activity. There are several binding domains on thrombin including the active site, anion-binding exosites I …
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Profile and anticoagulation outcomes of patients on warfarin therapy in an urban hospital in Cape Town: a review of records of patients attending Victoria Hospital, Cape Town, South Africa
… Warfarin is the most frequently used oral anticoagulant worldwide and it is the oral anticoagulant of choice in South Africa for reducing thrombosis - related morbidity and mortality. However, the safety and efficacy of warfarin therapy depends mainly on careful monitoring and maintenance …
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Characterisation of the potentially diverse transcriptional regulatory mechanisms of human coagulation PZ gene.
… been reported as having both procoagulant and anticoagulant activity, but its anticoagulant role appears to be more physiologically relevant. PZ levels vary widely among healthy individuals (normal range of 0.6 to 5.7 mug/mL) with the average being higher in men than women. The aim of this …
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