Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 138 for “"anticancer drugs"”.
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Cellular responses to platinum-based anticancer drugs
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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Silver (I) Complexes as Antimicrobial and Anticancer Drugs
… (9-acaH) and imidazoles as new antimicrobial and anticancer drugs. The detailed synthesis of silver(I)-containing carboxylates, such as polymeric [Ag2(9-aca)2]n and [Ag2(9-aca)2(DMSO)2]n, and the ammoniacontaining complex, [Ag4(9-aca)4(NH3)2], are provided along with imidazole derivatives, such as …
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Probing Non-Canonical DNA Structures With Anticancer Drugs
… our results may be useful in future design of drugs that can recognize and act on a certain gene sequence specifically.
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Cellular responses against DNA damaged by platinum anticancer drugs
The anticancer activity of platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin is mediated by their ability to attack DNA such that generated adducts trigger numerous cellular responses. A better understanding of these processes is critical for developing more effective therapeutic …
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Self-assembled Polymeric Nanoparticles for Targeted Delivery of Anticancer Drugs
Targeted delivery of drugs to specific regions of the body, or even to specific regions of the cell, promises enhanced drug efficacy and reduced systemic toxicity. By covalently coupling targeting ligands, the smart drug delivery systems are capable of targeting specific cell types exclusively …
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Platinum Complexes With Tridentate Ligands as Models for Active Monofunctional Anticancer Drugs
… DNA structural distortions associated with anticancer activity. Some distortions induced by difunctional cisplatin are also found for monofunctional Pt(II) complexes with carrier ligands having bulk projecting toward the guanine base. This ligand bulk can be correlated with impeded rotation …
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Interactions of Anticancer Drugs With DNA Studied by High-Resolution NMR Spectroscopy
… for the future design of bisanthracycline drugs.
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A mechanistic assessment of novel anticancer drugs targeting the metastatic cascade and tumour vascularisation.
… blood vessels represent an important target for anticancer drugs. The two classes of antivascular chemotherapeutics are vascular-disrupting agents (VDA) that target already established tumour blood vessels, and compounds with antiangiogenic acitivity that interfere with processes during the …
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Activity of Analogs of Anticancer Drugs on the Serine Protease Enzymes Subtilisin and Chymotrypsin
<p>The anticancer activity of several platinum compounds is due to the formation of complexes with DNA. We hypothesize that the size and shape of the platinum compounds would impact interaction with proteins, and these interactions may be partly responsible for the anticancer activity. Chymotrypsin …
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Effect of Mesoporous Silica-Loaded Anticancer Drugs on 3D vs 2D Models of Colon Cancer Cells
… drug delivery. Furthermore, tumour resistance to anticancer drugs warrants evaluation in a suitable 3D model mimicking in vivo tumours. This study investigated the impact of a potential chalcone-based anticancer drug, DMU121, and oxaliplatin (OXA) used in treating CRC. Both anticancer drugs were …
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Effectiveness of a closed system device in reducing occupational exposure and environmental concentrations of anticancer drugs
Owing to their non-selective nature, anti-cancer drugs affect both cancerous and non-cancerous cells and present a major health risk to healthcare staff working with them. This project was conducted at Derriford Hospital, Plymouth, to investigate the extent of contamination with anti-cancer drugs …
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Investigating the occurrence and fate of anticancer drugs in sewage treatment works and the wider aquatic environment
… is of growing concern. This thesis focuses on anticancer drugs - a group of biologicallypotent and often recalcitrant set of chemicals whose fate and impact on the wider freshwater environment is poorly studied. The aims of this thesis were to prioritise a group of anticancer drugs for …
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Study on interactions of new anticancer drugs and their utilization for modulation of multidrug resistance in solid tumors
Univerzita Karlova, Farmaceutická fakulta v Hradci Králové Školicí pracoviště Katedra farmakologie a toxikologie Doktorský studijní program Farmakologie a toxikologie Kandidátka / kandidát M.Sc. Youssif Budagaga Školitelka / školitel Assoc. Prof. RNDr. Jakub Hofman, Ph.D. Konzultantka / konzultant …
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High-resolution NMR spectroscopic analysis of anticancer drugs, DNA and their interactions: 1. Platinum anticancer compounds - DNA interactions. 2. Anthracycline drugs - DNA interactions and modified DNA
Chemotherapy with anticancer drugs is one of the main method of cancer treatment. The exploitation of the stereochemical interactions between anticancer drugs and DNA is of great importance for the ultimate clinical advances of cancer chemotherapy, which needs the detailed structural knowledge of …
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An implantable hydrogel for the delivery of cisplatin and the ex vivo neurotoxic, neuromyopathic and cardiotoxic activity of platinum-based anticancer drugs and macrocyclic drug delivery systems
Cisplatin is currently a leading anticancer drug used in the treatment of various cancers. Its clinical use, however, is limited by its poor bioavailability, its undesirable toxic side effects profile and by the ability of certain tumours to develop cisplatin resistance. A method that may overcome …
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The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 and triple-negative MDA-MB 231 breast carcinoma cell lines
… course and the development of resistance to anticancer and adjuvant endocrine therapies. Anti-EGFR compounds that specifically target the intracellular and extracellular domains of the EGFR include tyrosine kinase inhibitors (TKIs), e.g., gefitinib and erlotinib and monoclonal antibodies, …
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HPLC analysis to assess efficacy of cisplatin, nedaplatin, and oxaliplatin
Platinum drugs are one of the most widely used agents against cancerous cells. Cisplatin’s chemotherapeutic efficacy is limited by the increase of tumor resistivity and unwanted side effects. Cisplatin’s cytotoxicity is linked to its ability of forming 1,2-intrastrand adducts with adjacent guanine …
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MACROPHAGE MEDIATED DRUG DELIVERY TO TUMOUR CELLS IN VITRO
… side-effects associated with clinically used anticancer agents and metastases, which can still develop to form secondary tumours even after a primary tumour has been successfully treated. To minimise both of these problems, methods are being developed to target anticancer drugs to both primary …
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1. X-ray crystallographic analyses of the gene V protein from Ff bacteriophage, a single-stranded DNA-binding protein, and its Y41 mutants 2. X-ray crystallographic analyses of several anticancer drugs and their interactions with DNA
… detailed structural knowledge of DNAs, proteins, drugs, as well as their complexes with each other. Gene V protein (GVP) encoded by the filamentous bacteriophage Ff (M13, f1, fd) is a single-stranded DNA (ssDNA) binding protein which binds to ssDNA non-specifically and cooperatively. The structure …
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