Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"anticancer drug candidates"”.
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Development and Evaluation of Organometallic Anticancer Drug Candidates
There is an urgent need to find novel anticancer therapeutics with different mechanisms of action than platinum-containing drugs, particularly for patients who relapse after having been initially treated with a platinum-containing chemotherapy regimen. This chemoresistance phenomena, along with the …
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Development and Evaluation of Organometallic Anticancer Drug Candidates
There is an urgent need to find novel anticancer therapeutics with different mechanisms of action than platinum-containing drugs, particularly for patients who relapse after having been initially treated with a platinum-containing chemotherapy regimen. This chemoresistance phenomena, along with the …
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Synthetic strategies for the design of platinum anticancer drug candidates
Chapter 1. The Synthetic Chemistry of Platinum Anticancer Agents Since the inception of cisplatin as a clinically approved anticancer agent, a large number of platinum compounds have been synthesized with the aim of finding new, improved drugs. As a result of these efforts, only two additional …
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Advanced Quantum Mechanical Simulations of Circular Dichroism Spectra
… for naturally occurring antiplasmodial and anticancer drug candidates. We find that by comparing the computational results directly with those obtained through experimental measurement, we can provide reliable absolute config- uraitonal assignments to a variety of chiral compounds with …
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DOCKING STUDIES OF CURCUMIN ANALOGS AGAINST METHIONINE AMINOPETIDASE 2 AND BIOLOGICAL EVALUATION OF LEAD MOLECULES IN COLON CELLS
… There are different challenges in developing a drug for cancer treatments which include tumor selectivity, target specificity, drug efficacy, and overcoming multi-drug resistance (MDR). Designing target specific molecules has brought better success in developing new anticancer agents. Various …
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Structural and functional consequences of platinum anticancer drug binding to free and nucleosomal DNA
… are three FDA-approved members of the platinum anticancer drug family. These compounds induce apoptosis in tumor cells by binding to nuclear DNA, forming a variety of adducts, and triggering cellular responses, one of which is the inhibition of transcription. The focus of this thesis is on …