Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"anticancer agent"”.
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Novel Perspectives on the Utilization of Chemotactic Salmonella Typhimurium VNP20009 as an Anticancer Agent
… tumor targeting ability, being well studied for anticancer effects in mice. In 2001 Phase 1 Clinical Trials, patients diagnosed with melanoma were introduced with VNP20009, resulting in safe delivery of the strain and targeting to the tumor, however no anticancer effects were observed. Recently, …
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Mechanistic investigation of an anticancer agent that damages DNA and interacts with the androgen receptor
The 11[beta] molecule comprises a ligand for the androgen receptor (AR), which is crucial to progression and survival of many prostate cancers, tethered to a DNA-damaging aniline mustard. The compound was designed to exhibit selective toxicity toward prostate cancer cells by forming sites of …
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Synthesis and Spectroscopic Study of Anticancer agent A-007 Prodrugs and Progress Towards the Synthesis of Tetramic acid Antibiotics
… water solubility. To make use of this promising anticancer drug either orally or intravenously, the short-term obstacle must be to overcome the limited solubility of A-007 in water. There are several approaches to overcome this obstacle. The first approach is to make hydrolysable prodrugs of …
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CHARACTERIZATION OF THE RNA BINDING MODE OF A PLATINUM-ACRIDINE AGENT
… is a DNA-targeted anticancer agent that shows activity in a broad range of solid tumor cell lines. Unlike the classical platinum-based cross-linking drugs, this agent produces its cytotoxic effect by two synergistic DNA binding mechanisms: monofunctional platination …
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Investigation of the Biological Effects of Rosemary (Rosmarinus Officinalis L.) Extract in Human Lung Cancer Cells
… rosemary extract (RE) has been reported to have anticancer effects in vitro and in vivo however, limited evidence exists regarding the effects of RE and its polyphenolic constituents carnosic acid (CA) and rosmarinic acid (RA) in lung cancer. The present study shows RE, CA and RA inhibit lung …
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Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity
<p>Cisplatin is the most widely used anticancer agent; however, the cellular pharmacokinetics are poorly understood. Cisplatin is predominantly eliminated through the urine via active secretion and is associated with nephrotoxicity. Currently, prehydration therapy is employed to prevent toxic renal …
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Synthesis of labelled precursors of podophyllotoxin
Podophyllotoxin is an aryltetralin lignan and anticancer agent produced by the <i>Podophyllum</i> and some other species and is extracted from Podophyllin in up to 30 percent yield. Little definitive information is available on the biosynthetic pathways to podophyllotoxin. Administering various …
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Supramolecular derivatives of selected bioactive compounds : a physicochemical study
… of three bioactive compounds: the steroidal anticancer agent 2-methoxyestradiol [polymorphs and cyclodextrin (CD) inclusion complexes], its derivative 2-methoxyestradiol-bis-sulfamate (polymorphs), and the antiretroviral agent, nevirapine (co-crystals). The solubility and dissolution profiles …
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Assessing bioactivity of a peptide from the skin secretion of Rana amurensis
… that many AMPs exhibit potent antimicrobial or anticancer activities, which has attracted increasing interest from researchers studying novel drug leads.<br/><br/>In this study, experiments were conducted to determine the biological activities of a peptide derived from the skin secretion of Rana …
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In-depth bioinformatics analysis of the phosphoproteome of triple negative breast cancer treated with a tumor selective NQO1 bioactivatable drug
… in response to a novel bioactivated anti-cancer agent IB-DNQ (isobutyl-deoxyniboquinone). NQO1 or NADPH:quinone oxidoreductase-1 is a detoxifying enzyme overexpressed in many solid tumors and low expression in normal cells. IB-DNQ is bio-activated by NQO1 enzyme via a futile redox cycling, …
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The use of novel poly(allylamine) based amphiphilic polymers for drug delivery.
… prednisolone griseofulvin, etoposide and novel anticancer agent BNIPDaoct. The Ch5 and Dansyl10 showed excellent drug solubilisation capacities. At 6 mgmL-1 the Ch5 achieved propofol solubility 70-fold greater than its aqueous solubility, prednisolone, griseofulvin and etoposide solubilitys were …
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The chemistry of cephalomannine
… taxane diterpenoid closely related to the potent anticancer agent Taxol. Three aspects of its chemistry were examined. First, cephalomannine was converted to Taxol. This conversion was accomplished by the reaction of a 2'- benzoyl-7-Troc cephalomannine/Taxol mixture with oxalyl chloride to …
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Syntheses and Bioactivities of Targeted and Conformationally Restrained Taxol Analogs
… Wall and Wani. Although its development as an anticancer agent was delayed by numerous reasons, including its scarcity and insolubility, the discovery of its tubulin-assembly activity and other factors motivated oncologists to overcome these problems. It has since become one of the most …
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Studies on the synergic activity of a three-drug cocktail active against cisplatin-resistant human leukemia and carcinoma cells
… properties and limits of cisplatin (CDDP) as an anticancer agent, and in view of the potential clinical relevance of the synergic effect of CDDP with the Cu(II)-phen complexes previously reported against T-leukemia cells (Pivetta et al.,Talanta, 2013), my research project was aimed at (1) …
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The Expression of Copper Transporters in Rat Dorsal Root Ganglion Neurons and its role in Oxaliplatin Neurotoxicity
Oxaliplatin is a platinum-based anticancer agent used for the treatment of colorectal cancer. Oxaliplatin chemotherapy is associated with peripheral neuropathy and dorsal root ganglia neurons are the putative target, however the mechanism of toxicity is currently unknown. Recent evidence suggests …
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Modified taxols as anticancer agents
Modifications of the potent anticancer agent taxol were carried out in order to gain an understanding of the chemical reactivity of the drug and the factors which contribute to its biological activity. The C-2' and/or the C-7 hydroxyl groups of taxol were substituted with acetyl, ßalanyl, silyl, …
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Analysis of dirhenium carboxylate : purine dinucleotide adducts
… NH<sub>3</sub>)<sub>2</sub>Cl<sub>2</sub>], as an anticancer agent in 1969 by Rosenbert and his colleagues sparked interest in the area of metal complexes as chemotherapeutic agents. Anticancer dimetal complexes such as …
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Synthesis of Novel Sulfonamide-Based Calpain Inhibitors and Their Potential as Anti-Tumor Agents
… are therefore of interest as therapeutic agents and as biomedical tools.</p> <p>Several potent calpain inhibitors isolated from natural sources as well as synthesized in the laboratory have been reported (Chapter 1.4). Unfortunately, most of the inhibitors show poor calpain selectivity, …
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Assessment of taxol activity: Bioavailability in human physiological fluids and QSAR of taxol analogues based on a neural network design
Taxol is an anticancer agent that is highly protein bound. This feature is addressed in the first chapter by developing a competitive, enzyme-linked immunosorbent assay (ELISA) to quantify bioavailability of taxol in human fluids: plasma, plasma ultrafiltrate and salivary fluids. An optimization …
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