Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"antibody-dependent cellular cytotoxicity"”.
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Age-Dependency of Swine Antibody-Dependent Cellular Cytotoxicity Against Pseudorabies Virus-Infected Cells
Pseudorabies is an age-dependent infectious disease primarily of swine caused by pseudorabies virus (PRV), a member of the herpesvirus family. The reasons for age-dependency of PRV are not known, but in some herpesvirus infections resistance was associated with macrophage maturation. In pigs, …
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Comparing high-throughput methods to measure antibody dependent cellular cytotoxicity during HIV infection
… against HIV are complex and involve both cellular and humoral immunity. Based on the recent finding that the best correlate of protection against the first protective prophylactic RV144 vaccine were HIV-specific antibody responses, including those mediating natural killer (NK) cell …
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Design, Synthesis And Biological Evaluation Of Small Molecules That Inhibit Hiv-1 Entry And Sensitize Hiv-1 Infected Cells To Immune Responses
… and sensitization of HIV-1 infected cells to antibody-dependent cellular cytotoxicity (ADCC). The first part of my thesis describes the development of a late-stage derivatization strategy for the synthesis of 1,2,5,7-tetrasubstituted aminoindane small molecule CD4mc and the corresponding …
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JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
… chemokines and DAMPs such as IL-1β and extracellular ATP. RNA sequencing of murine macrophages co-cultured with infected human tumor cells showed enrichment of chemotactic and pro-inflammatory pathways as well as increased Fc receptor activation following OncoD-0J1 infection. Single-cell RNA …
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Functional Modeling of Genes Upregulated in Chronic Myeloid Leukemia
… stem cells. The use of a polyclonal IL1RAP antibody enabled antibody-dependent cellular cytotoxicity (ADCC) of CD34+CD38- CML cells in vitro. In Article III, the function of IL1RAP in normal hematopoeisis and in CML was investigated. Mice lacking Il1rap displayed lower myeloid steady-state …
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A Novel Syndecan-1 Targeted Therapeutic Antibody Inhibits Macropinocytosis and Induces Anti-Tumor Immunity in Pancreatic Cancer
… of pancreatic cancer, we developed a monoclonal antibody with remarkable sensitivity and specificity for human SDC1 (anti-SDC1 mAb). Anti-SDC1 mAb robustly inhibited PDAC cell proliferation <em>in vitro</em> and exhibited potent tumor inhibitory effects across multiple PDAC models. …
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Development and Characterization of A Bi-Specific Antibody Targeting Hla-A2/Pr1
… of a T cell receptor-like monoclonal antibody (h8F4) that targets PR1/HLA-A2 and eliminates AML xenografts by antibody-dependent cellular cytotoxicity (ADCC) following repeat dosing. To improve the potency of h8F4, we have developed a bi-specific T cell-engaging antibody that targets …
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Chimeric ANTI-CD19 Monoclonal Antibodies for the Treatment of Precursor B Cell Acute Lymphoblastic Leukemia
… HD37 MAb were equally effective at mediating antibody dependent cellular cytotoxicity (ADCC) with mouse effector cells. The anti-tumor activities of all three MAbs were identical in SCID mice xenografted with human B cell tumors. However, the chimeric tetravalent MAb has a higher binding …
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Importance of specific NK cell subsets for antitumor immunity in HPV+ cancers
… B (GrnzB) and CD16, an NK receptor important for Antibody Dependent Cellular Cytotoxicity (ADCC). In HPV+ head and neck patients, post-SOC, the circulating pre-mNK cells exhibited significant increases in GrnzB and CD16, indicating elevated cytotoxic potential after treatment. In cervical cancer …
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The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… of signaling pathways required for natural and antibody dependent cellular cytotoxicity (ADCC) of human NK cells. In this study, I show that Vav-1 is also expressed in murine NK cells. Vav-1-/- mice had normal numbers of splenic NK cells, and these displayed a similar expression profile of NK …
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DESIGN, SYNTHESIS, AND OPTIMIZATION OF SMALL-MOLECULE CD4 MIMETICS AS HIV-1 ENTRY INHIBITORS AND SYNTHETIC EFFORTS TOWARD THE TOTAL SYNTHESIS OF NAHUOIC ACID Cii
This thesis comprises two independent parts.Part I: The persistent challenge of human immunodeficiency virus (HIV-1) eradication is driven in part by the virus’s capacity to evade immune recognition through conformational masking of its envelope glycoprotein (Env). Small-molecule CD4 mimetic …
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Humoral immune response to melanoma: discovery and evaluation of anti-melanoma antibodies
… cell repertoire of individuals with melanoma for antibody subclass composition and the presence and prevalence of anti-tumor antibodies; and (3) to study patient-derived antibodies and two engineered antibodies recognizing melanoma cells for their propensity to activate immune effector cells and …
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Discerning the Mechanism of Gamma Delta T Cell-Mediated Damage in Multiple Sclerosis: the Potential Role of Antibodies in Disease Pathogenesis
… Fc receptors (FcR), such as CD16, that bind antibody are more prominent with MS disease progression and have been shown to exert cytolysis via antibody-dependent cellular cytotoxicity (ADCC). We postulated that if there were also relevant and detectable antibodies in MS patients that might …
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Methods in Total Synthesis: Development of a 2nd-Generation Synthesis of CJF-III-288, and Synthetic Efforts Towards the Total Synthesis of Sequoiamonascin A
… cells and increases HIV+ plasma mediated antibody-dependent cellular cytotoxicity (ADCC). These results justified the development of a more efficient synthesis of CJF-III-288 to access larger quantities of the compound to assess CJF-III-288’s ability to sensitize HIV-1 infected cells to …
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The impact of neutralizing antibody and ADCC responses on HIV-1 envelope evolution in early infection
… and non-human primate vaccine studies suggest antibody-dependent cellular cytotoxicity (ADCC) responses, which target virus-infected cells, may also be protective. This thesis uses deep sequencing, together with immune assays, to characterise HIV-1 Envelope evolution associated with both nAb …
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Evaluating the Impact of Antibody Epitope and Function on HIV-1 Vertical Transmission
… the global burden of HIV/AIDS. The humoral or antibody response is one aspect of the immune system that contributes to vaccine-mediated protection from pathogen infection. Studies in animal models have provided proof of concept that HIV antibodies can protect from infection and pathogenesis. …