Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"antibody titer"”.
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Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays
Online monitoring of monoclonal antibody (mAb) product titers throughout biologics process development and production enables the implementation of quality-by-design biomanufacturing, rapid bioprocess decision-making, and process optimization. Intermittent sampling and analysis are presently …
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Factors that Affect the Immunogenicity of Lipid-PLGA Nanoparticle-Based Nanovaccines against Nicotine Addiction
… to elicit a significantly higher anti-nicotine antibody titer than the 500 nm nanovaccine. Secondly, the high-density nanovaccine exhibited a better immunological efficacy than the low- and medium-density counterparts. Thirdly, the nanovaccine with hapten localized on both carrier protein and …
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Evaluation of Transmissible Gastroenteritis and Porcine Respiratory Coronavirus Immunologic Interaction in Seronegative Pregnant Gilts
… significantly higher TGEV serum neutralizing antibody titers when compared with gilts sensitized to either PRCV or TGEV alone, Anti-TOEV IgG and IgA levels were assayed for in post-farrow milks from all gilt groups. Only IgG was detected which indicated a lack of mucosal priming. The second …
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West Nile Virus Seroreversion and the Influence of Herd Immunity on Disease Risk in a Long-term Study of Free-ranging Birds
… unexposed to WNV, and 3) adult birds with waning antibody titers. Although rarely tested, avian herd immunity and seroreversion could have a direct impact on Culex infection rate, a proxy for the reproductive number of WNV. In this study, we utilized data from a seven year study investigating WNV …
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Orally Induced Tolerance to Streptococcus Mutans and Glucosyltransferase in Neonatal Mice
… Radial immunodiffusion was used to measure the antibody response to vaccine and BSA, and an enzyme inhibition assay was employed to measure GTase antibody titer. Daily feeding during the first eight days of life resulted in a lower antibody response to the antigens upon subsequent challenge.
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Serologische Untersuchungen von Sauenmilch und Ferkelblut als mögliche Alternative zur Blutuntersuchung von Muttersauen im Rahmen der Bestandsdiagnostik
… Further more the development of the milk antibody concentration p.p. and a comparison of sows' and piglets' antibody titers was demonstrated. The results for the seroprevalence of the blood tested sows are as follows: AD 0 %, SI 93 %, EP 46 %, PPV 77 %, PRRS 0,7 %, TGE 4 %, PRCV 65 % and …
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Effects of Yeast Product on Modulating the Adaptive Immune Function in Broilers
… on day 21. The result of Newcastle Disease Virus antibody titer measurement showed that the population of treated group Immunoglobulin G was higher than control group after 1st vaccination at day 14 and increased faster than the control group after boost at day 21. Cell proliferation results from …
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Imunnoresponsiveness in Japanese quail and chickens
… and LHLH). Kinetics of primary and secondary antibody response to SRBC antigen was examined in Line C quail (Experiment 1). At most times post-primary inoculation (PPI), antibody titers were highest for antigen concentration 2.5%. The presence of MER antibodies was very low PPI, but increased …
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Effect of circovirus vaccination on immune responses, viral load, and growth performance of pigs under field conditions
… circovirus vaccination effects on PCV2 antibody titer, regardless of age and dose administration protocol, pigs vaccinated with a 2-dose circovirus vaccine had increased (P ≤ 0.008) antibody titers compared with non-vaccinates. In a second study, dosing strategy failed (P = 0.31) to …
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Evaluation of the Photometric Assay Method to Quantitate the Bactericidal Action of Normal and Immune Rabbit Sera on SALMONELLA PULLORUM
<p>The bactericidal antibody test depends on the presence of sufficient complement, magnesium ions, and specific antibody to produce killing of certain gram negative bacilli. This study was undertaken to demonstrate whether or not Salmonella pullorum is an organism which is susceptible to this …
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Adenovirus Vectors as Potent Adjuvants in Vaccine Development
… generate a robust and prolonged Pfs25-specific antibody response. We found that Ad5-pfs25, which expresses pfs25, generated a robust Pfs25-specific antibody response characterized by a higher titer, higher relative affinity, and broader IgG subclass switching as compared to alum-adjuvanted Pfs25 …
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Observations on the Pathogenesis of Canine Encephalitozoonosis
… a hypergammaglobulinemia, an anti-Encephalitzoon antibody titer, and an antigen-specific blastogenic response to E. cuniculi spores. Lymphocyte blastogenic responses to the lectin PHA were depressed compared to controls. The antibody response to T-lymphocyte dependent antigens, sheep erythrocytes, …
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Insights on Serology, CRISPR Diagnostics, and Machine Learning Architectures for Biological Sequences
… aspects of SARS-CoV-2, exploring the dynamics of antibody responses during primary infection and reinfection. First, we explore the dynamics of antibody responses during primary infection, revealing a “switch-like” relationship between antibody titer and function. Next, we investigate the humoral …
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Determinants of Immunity against the Meningococcus
… in the absence of complement relies on high antibody titer and my data suggests that phagocytic cells are necessary to clear the bacterial infection. Protection in the absence of IgG is reliant on bacterial specific IgM. Taken together, my findings provide novel insight into the mechanism of …
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The effects of erythrocyte alloantigen L on the avian immune response
… 2 examined the influence of Ea-L on antibody response to SRBC and Brucella abortus (BA). The mating protocol was the same as in Experiment 1. At 4 and 11 weeks of age the experimental birds were injected intravenously with standard concentrations of SRBC and BA. Total and ME-resistant …
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Investigation of selected variables from the primary and secondary circulatory systems in rainbow trout (Oncorhynchus mykiss)
… plaque assay and a negative outcome from antibody titer tests in both circulatory systems, suggests that the adaptive (specific) immune response may not have been stimulated.
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Untersuchungen zum Zeckenbefall und zur Prävalenz von Borrelia burgdorferi sowie Babesia divergens beim Rind im bayerischen Voralpenland
… by immunfluorescence techniques (IFAT), revealed antibody-titers ≥ 1:64 for 45,6 % of the animals. 27 of 31 farms showed prevalences of Borrelia burgdorferi ranging from 20 to 100 %. There were no significant differences of positive cattle between the various areas. However, a significant …
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Development of Virus-like particles (VLPs) Based Vaccines Against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Epidemic Diarrhea Virus (PEDV)
… able to elicit significant viral neutralization antibody titer in gilt milk at 3 days post-farrowing (DPF), and provided nursing piglets with clinical relief in terms of morbidity, viral shedding, small intestinal lesions, and 10 days post-challenge (DPC) survival rate.
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Genotype by feeding regimen interactions in growth selected chickens
… ratios, and increased immune organ weight, antibody titer to sheep red blood cell (SRBC) antigen and livability than ad libitum fed birds. Body weights were similar by 56 days of age, and there was sexual dimorphism for rate of accelerated growth. Long term obesity, but not short term weight …
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FVIII Immunity : early events and tolerance mechanisms to FVIII
… that the C57BL/6 mice developed higher FVIII antibody titers than the Balb/c mice. Our results suggest that differences in the cytokine immune responses due to FVIII in Balb/c and C57BL/6 mice are responsible for the different FVIII antibody titers in each of these strains. Second, we …
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