Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"antibody therapy"”.
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Potentiating Antibody Therapy by Targeting Complement on Cancer Cells
… which are no longer sensitive to the anti-CD20 therapy. In a clinical trial we initiated with anti-CD20 mAb ofatumumab in chronic lymphocytic leukemia (CLL), we observed that these escape variants carried covalently bound complement activation fragments, especially C3d. Indeed, C3d opsonized CLL …
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Optimisation of analytical methods for monitoring monoclonal antibody therapy in Inflammatory Bowel Disease
… can be successfully treated with the monoclonal antibody therapies Infliximab and adalimumab. However, low drug levels and immunogenicity (development of anti-drug antibodies) are associated with treatment failure. Therapeutic drug monitoring, using drug and anti-drug antibody measurements …
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Monoclonal Antibody Therapy: The Development of a Liquid Chromatography Tandem Mass Spectrometry Method to Measure Rituximab Concentrations in Human Plasma
… of substantial interest in recent years as a therapy. The aim of this research project is to develop and optimise the extraction and quantification of RTX in human plasma using appropriate sample preparation techniques and liquid chromatography tandem mass spectrometry (LC-MS/MS) as the …
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Mathematical Models of Immune Responses to Infectious Diseases
… dynamics model, iii) A study of monoclonal antibody therapy. We predict that the condition leading to HPV persistence during HIV/HPV co-infection is the permissive immune environment created by HIV, rather than the direct HIV/HPV interaction. In the second project, we develop a germinal …
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BiTEs and CAR-Ts : immunotherapy in childhood B-cell acute lymphoblastic leukemia
… deaths in children. Advances in chemotherapy over the past half-century have steadily increased the remission and survival of children with B-cell acute lymphoblastic leukemia to nearly 90%. However, the problems of minimal residual disease and relapsed and refractory disease persist. …
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T cell mediated combination immunotherapy
Immunotherapy is a broad treatment strategy that harnesses the immune system to fight off a particular condition or disease. Cancer immunotherapy is the specific application of agents designed to interact or stimulate the immune system to fight off tumors. Treatments as diverse as passive antibody …
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Dynamics of HIV-1 Infection and Therapy In Vivo
… while treatable with suppressive antiretroviral therapy drugs (ART), establishes lifelong persistence in the infected host as a natural consequence of the viral life cycle and the dynamic properties of the human immune cells in which HIV-1 propagates. This persistence is driven by populations of …
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Targeting c-Met for therapy
… cloned and subjected to preliminary monoclonal antibody characterisation. 11 monoclonal antibodies were finally selected for ascites production and antibody purification. These purified antibodies were characterised by Western blotting, immunofluorescence staining, functional assays (ERK …
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Antibody engineering for cancer therapy
… cancer. In this Thesis, novel antibodies and antibody-conjugate against two tumor antigens, AF-20 antigen and human aspartyl (asparaginyl) [beta]- hydroxylase (HAAH), were developed. Previously, these two tumor antigens have been shown to be present on a variety of tumor cells, while they have …
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A Study of Craniofacial Growth in Infant Heart Transplant Recipients Receiving Cyclosporine
… None of the subjects had undergone orthodontic therapy. All subjects had heart transplantation before six months of age and followed the Loma Linda University International Pediatric Heart Transplantation Immunosuppression protocol. The primary immunosuppression agent was cyclosporine with …
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Putative Roles of Cd200 In The Leukemogenesis and Immune Evasion of Leukemia Stem Cells
… are capable of surviving current standard chemotherapy and are the likely source of deadly, relapsed disease. While stem cell transplant serves as proof-of-principle that AML LSCs can be eliminated by the immune system, the translation of existing immunotherapies to AML have been met with …
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Therapeutic Uses of Broadly Neutralizing Anti-HIV-1 Antibodies in Humanized Mice
<p>Combination anti-retroviral drug therapy (ART) significantly suppresses HIV-1 viremia in most infected individuals, but is incapable of curing disease. The major barrier to HIV-1 cure is a population of long-lived cells that harbor replication-competent provirus and are refractory to current …
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A Continued Investigation of Craniofacial Growth in Infant Heart Transplant Recipients Receiving Cyclosporine
… None of the subjects had undergone orthodontic therapy. All subjects had heart transplantations before six months of age and followed the Loma Linda University International Pediatric Heart Transplantation immunosuppression protocol. The primary immunosuppression agent was cyclosporine with …
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Isolation of Therapeutic Antibodies Against Microseminoprotien to Potentially Overcome Resistance to Anti-Angiogenic Therapy
… nutrients. While platinum-taxane doublet therapy in addition to cytoreductive surgery has been the gold standard treatment for patients with ovarian cancer, greater than 70% of patients will develop relapsed disease and be burdened with a terminal condition. Consequently, there is an …
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MODULATION OF THE B-CELL REPERTOIRE IN RHEUMATOID ARTHRITIS BY TRANSIENT B-CELL DEPLETION
… known that they have roles in addition to (auto) antibody production and are involved by different mechanisms in the regulation of T-cell mediated autoimmune disorders. The evolution of an autoimmune disease is a dynamic process, which takes a course of years during which complex immunoregulatory …
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Radioimmunotherapy of Metastatic Disease - Studies of Alpha- and Beta-particle-Emitting Radionuclides in a Preclinical Model
In radioimmunotherapy, monoclonal antibodies (mAbs) are used as a targeting agent carrying a toxic payload consisting of radionuclides. This treatment allows the irradiation of small lesions, even on the microscopic level. In the present work, two radionuclides with different properties were used. …