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Showing 1 to 7 of 7 for “"antibody diversity"”.

  1. Investigation of IGF1R/IRS1 Signalling Mechanisms in B Cell Development

    … heavy and light chain variable (V), diversity (D) and joining (J) genes are differentially rearranged in VDJ recombination. This assembles a complete B cell receptor (BCR) and is the primary step in producing a diverse BCR repertoire; an essential requirement for a robust adaptive …

    cambridge Repository record for Investigation of IGF1R/IRS1 Signalling Mechanisms in B Cell Development (opens in a new tab)

  2. Heterogeneity and Impaired IGF1R Signalling in Aged B cell Development

    … B cell receptor (BCR) is secreted as antibody to neutralise pathogens or mediate the immune response. A diverse repertoire of immunoglobulin molecules is therefore essential for immune surveillance. As we age however, antibody diversity declines, as does our ability to mount a …

    cambridge Repository record for Heterogeneity and Impaired IGF1R Signalling in Aged B cell Development (opens in a new tab)

  3. The Ontogeny of Antigen-Binding Cells

    … cells capable of undergoing differentiation into antibody secreting cells. This assay was then used to characterize cells specific for each of eleven different hapten and protein antigens. In all cases, specific antigen-binding cells were first detected in the liver, on the 15th day of the 19-day …

    rockefeller Repository record for The Ontogeny of Antigen-Binding Cells (opens in a new tab)