Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"antibody diversification"”.
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The Role of Activation-Induced Cytidine Deaminase in Antibody Diversification and B Cell Malignancies
… (CSR) in B cells. SHM alters the affinity of an antibody for its corresponding antigen by introducing point mutations within the variable region of the immunoglobulin (Ig) gene heavy chain locus. CSR replaces the Ig μ constant region with one of the downstream constant region, thereby changing …
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The Effect of Activation Induced Cytidine Deaminase Phosphorylation and Herpes Virus Uracil Dna Glycosylase On Antibody Diversification
… expressed in mammalian B-cells and initiates the antibody diversification processes of somatic hypermuntation (SHM) and isotype class switch recombination (CSR). AID is targeted to the immunoglobulin gene locus where it deaminates cytosines to generate uracil residues in DNA. This generates …
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Taming a Potent Mutator: Identification and Characterization of Novel Mechanisms of Regulating Antibody Diversification in B-Lymphocytes
… have developed extensive mechanisms of gene diversification collectively known as antibody diversification. Antibody diversification, a set of processes necessary for an organism to mount a specific and robust immune response, relies on Activation Induced Cytidine Deaminase (AID) to initiate …
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Investigation of Ring Finger Protein 8 in Mammalian Physiology and Pathogenesis
… recombination (CSR), an important mechanism for antibody diversification and specification of immunoglobulin effector function during a humoral immune response in mammals. Through catalyzing ubiquitylation of the H2A-type histones flanking DNA DSBs, the E3 ligase Ring finger protein 8 (Rnf8) …
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In vitro diversification of chimeric human/chicken antibodies
… line has been adapted for the expression and diversification of humanized antibodies. Human antibodies in the form of scFvs expressed in the surface of these cells have been successfully diversified to produce a scFv library, from which antibodies of desired specificity and improved affinity …
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Investigation of the role of the DNA-modifying enzyme, activation-induced cytidine deaminase (AID), in cancer
… cytidine Deaminase (AID) is essential for antibody diversification and plays an important role in immunity. AID is specifically expressed in activated B-cells and mutates targeted DNA sites, diversifying the antibody repertoire. Due to its mutagenic nature, AID expression is tightly …
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Genome-Wide Characterization of the Effects of Nucleic Acid Modifying Enzymes: Cytidine Deaminases and DNA Methylation
… is essential for two processes of immunoglobulin diversification in germinal center B cells: somatic hypermutation (SHM), in which mutations are introduced into immunoglobulin (Ig) genes, and class-switch recombination (CSR), in which genomic constant regions are recombined to encode antibodies of …
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Probing RNA binding specificities of AID/APOBEC proteins by iCLIP
… valuable physiological functions including antibody diversification and restriction of viral infection. However, off-target mutations have also been shown to contribute to cancer development, making it crucial to better understand the interactions and mechanisms that regulate AID/APOBEC …
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STRUCTURAL STUDY OF HUMAN CATENIN ΒETA-LIKE PROTEIN 1 AND DOUBLE RNA PSEUDOKNOTS IN -1 RIBOSOMAL FRAMESHIFTING
… which is to act as an interaction partner of the antibody-diversification enzyme activation-induced cytidine deaminase (AID) for its nuclear import and subnuclear trafficking. In this dissertation, the crystal structure of full-length human CTNNBL1 is reported. The protein contains six armadillo …