Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"antibody development"”.
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CHARACTERIZATION OF DENGUE NEUTRALIZING ANTIBODIES USING RECOMBINANT ANTIBODIES TECHNOLOGY
… FOR SUBSEQUENT VACCINE AND THERAPEUTIC ANTIBODY DEVELOPMENT AS WELL AS FOR TODAY?S EXPLODING IMMUNOTHERAPY RESEARCH. THE FIRST HALF OF THIS THESIS IS DEDICATED TO THE CLONING, EXPRESSION, AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES OBTAINED FROM TWO NATURALLY INFECTED DENGUE PATIENTS. …
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Elucidating the role of BCL6 in helper T cell activation, proliferation, and differentiation
… of TFH and GC B cells is necessary for the development of high affinity antibodies specific for an invading pathogen. Germline BCL6-deficient mouse models limit our ability to study BCL6 function in T cells due to the strong inflammatory responses seen in these mice. To overcome this, our …
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A statistical mechanics approach to vaccination against HIV
… the same strain of pathogen. The key process in antibody development is a stochastic process known as affinity maturation (AM) which generates strain-specific antibodies upon immunization by one antigen. A highly mutable virus like HIV evades recognition by these strain-specific antibodies via …
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Adaptive Evolution of Surface Proteins in Microbial Pathogens: Lyme Disease Pathogens (Borreliella sp.) and Human Immunodeficiency Virus Type 1 (HIV-1)
… were identified, and two of them were chosen for antibody development due to their strong antigenicity across host species. Four epitope-specific monoclonal antibodies were generated, with potential applications in detecting active <em>Borreliella</em> infections.</p> <p>The second chapter …
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Studies of Atherosclerosis in Systemic Lupus Erythematosus
… to loss of immune tolerance, increases autoantibody production, increases disease activity in women and accelerates the SLE phenotype in mice. A major cause of death and disability in women with SLE is accelerated lupus-associated atherosclerosis (ALAA). The overarching hypothesis of this …
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A Point-of-Care Immunoassay for Ultra-Sensitive Detection of Ebolavirus
… assay sensitivity and overall performance. While antibody development has witnessed a significant evolution over time, mostly driven by the interest in antibody-based drugs, major challenges still exist in the IVD reagent generation process. Regarding NSPA, only recently protein resistant surfaces …
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The Regulation of Phosphorylation Events in Platelets
… of ADP receptors. Technological advances in antibody development have resulted in the generation of commercially available phospho-specific antibodies for MLC phosphorylated on either threonine (Thr) 18 or serine (Ser) 19. These antibodies allowed us to revisit these prior studies and address …
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The role of Human Endogenous Retrovirus K10 (HERV-K10) in the pathogenesis of rheumatoid arthritis via molecular mimicry
… cross-reactivity of novel anti-K10 polyclonal antibody (PAbMAG) with IgG1 Fc. We showed that PAbMAG cross-reacted with linear and conformational epitopes on IgG1 Fc. In a further development, we showed a significantly elevated mean IgG response to HERV-K10 epitopes in serum samples from RA …
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Interrogating structure-function relationships in the pathogenesis and treatment of human disease : insights into the development of therapeutics for emergent tropical viruses
… structure-function relationships involved in development of disease is a critical component for the rational design of successful therapeutics, allowing researchers to target precise molecular mechanisms and to anticipate and address future challenges early in development. However, for many …