Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"antibody delivery"”.
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Self-Assembling Bioaffinity Hydrogels for Localized Antibody Delivery
… might mitigate the risk of such toxicities. Antibody drugs are formulated typically for parenteral delivery because of degradative mechanisms in gastrointestinal tract. The assumption has been that systemic administration via the vascular compartment is the best or only option in achieving …
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Controlling antibody delivery, mechanical properties, and cell response of alginate-chitosan polyelectrolyte complexes
… proteins or antigens. The antiangiogenic antibody, bevacizumab, targets and binds to VEGF to prevent angiogenesis. Bevacizumab has been approved for the treatment of recurrent glioblastoma, with concurrent radiation and chemotherapy, however the clinical efficacy of bevacizumab is still …
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Bioconjugate Strategies for Antisense Therapeutic Delivery to Glioblastoma Stem Cells
… where oncogenic genes are over-expressed. The delivery of antisense therapeutics to target cells presents a significant challenge due to the many barriers a nucleic acid must face in order to reach the cytoplasm where it exerts its effects. In this thesis, I explored multiple strategies for …
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Modulation of Immunity via Antibodies Displayed on in situ Forming Peptide Co-assemblies
… region (Fc) for protein A/G (pAG). A therapeutic antibody can be displayed through non-covalent Fc-pAG interactions. Proof-of-concept studies demonstrate that antibodies were displayed via His-tags through the linker proteins, namely His-tag/αH6-IgG/pAG interactions. Displayed antibodies remained …