Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"antibiotic resistance genes (ARGs)"”.
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GENOMIC SURVEILLANCE AND RISK-BASED ASSESSMENT OF ANTIBIOTIC RESISTANCE TRANSMISSION ACROSS TROPICAL AQUATIC ENVIRONMENTS
Antimicrobial resistance (AMR) transmitted through aquatic environments poses a growing public health threat, yet the genomic mechanisms governing resistance gene flow across interconnected water systems remain poorly understood. This thesis investigates β-lactam resistance transmission across …
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Antibiotic Resistance Genes in Marquette County Michigan's Wastewater
<p>Antibiotic-resistant bacteria evade standard treatments, increasing disease severity, patient morbidity, and mortality. Following exposure to an antibiotic, resistant bacteria survive and pass antibiotic resistance genes (ARGs) to their progeny cells. Few ARG studies have utilized wastewater …
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Assessment of a Passive Sampler for Aquifer Microbial Community Profiling and Comparison of Porous Media
… include the potential introduction of pathogens, antibiotic resistance genes (ARGs), and trace organic pollutants, as well as the disruption of native microbial processes critical for contaminant degradation in groundwater. However, it is very challenging to sample aquifer microbes in situ, …
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Shotgun metagenomic analysis of antimicrobial resistance in wastewater
Antimicrobial resistance (AMR) threatens our modern standard of living with the potential return to a pre-antibiotic condition where deadly infections are no longer treatable. Wastewater treatment plants (WWTPs) are vital components in water sanitation infrastructure and are now also being …
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Effect of Soil Type, Composting, and Antibiotic Use on Fate of Antibiotic Resistance Genes and Microbial Community Composition in Dairy and Beef Manure Applied Soils
… that this practice could affect the spread of antibiotic resistance genes (ARGs) from farm to fork. A microcosm-scale study evaluated the effect of prior antibiotic use (manure-based soil amendments generated from dairy and beef cattle with or without antibiotic administration), composting, and …
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Effect of wastewater colloids on membrane removal of microconstituent antibiotic resistance genes
Anthropogenically generated antibiotic resistance genes (ARGs) are considered emerging contaminants, as they are associated with a critical human health challenge, are persist independent of a bacterial host, are subject to transfer between bacteria, and are present at amplified levels in …
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Nanobiotechnology Enabled Environmental Sensing of Water and Wastewater
… transmission routes for infectious diseases, antibiotic resistance, and anthropogenic pollution. The need for environmental sensing has consistently been stressed as a means to minimize public health threats caused by such contaminants. Many analytical detection techniques have been developed …
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Biodegradation of QACs in lake and river water and effects on the microbial community
… concentrations can facilitate the evolution of resistance to QACs and may also lead to co-resistance to other antimicrobial agents. Few studies have investigated the impact of repeated exposure of sub-inhibitory concentrations of QACs in lake and river water to microbial communities in terms of …
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Advancing Monitoring and Mitigation of Antibiotic Resistance in Wastewater Treatment Plants and Water Reuse Systems
… receive a confluence of sewage containing antibiotics, antibiotic resistant bacteria, antibiotic resistance genes (ARGs), and pathogens, thus serving as key point of interest for the surveillance of antibiotic resistance (AR) dissemination. This thesis advances knowledge about the fate of …
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Metagenomic Analysis of Antibiotic Resistance Genes in the Fecal Microbiome Following Therapeutic and Prophylactic Antibiotic Administration in Dairy Cows
The use of antibiotics in dairy cattle has the potential to stimulate the development and subsequent fecal dissemination of antibiotic resistance genes (ARGs) in bacteria. The objectives were to use metagenomic techniques to evaluate the effect of antibiotic treatment on ARG prevalence in the fecal …
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A Framework for Standardized Monitoring of Antibiotic Resistance in Aquatic Environments and Application to Wastewater, Recycled Water, Surface Water, and Private Wells
Antimicrobial resistance (AMR) is a One-Health (human, animal, environment) challenge that requires collaborative, interdisciplinary action. Comparable surveillance data are needed to effectively inform policy interventions aimed at preventing the spread of AMR. Environmental monitoring lags behind …
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Integrative Metagenomic Approaches to Study Antibiotic Resistance Genes and Microbial Functions in the Preterm Infant Gut Microbiome
The widespread use of antibiotics has substantially improved clinical outcomes, particularly the survival of preterm infants. In neonatal intensive care units, antibiotics are frequently administered because these infants are at high risk of severe bacterial infections. However, early-life …
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DeepARG+ - A Computational Pipeline for the Prediction of Antibiotic Resistance
The global spread of antibiotic resistance warrants concerted surveillance in the clinic and in the environment. The widespread use of metagenomics for various studies has led to the generation of a large amount of sequencing data. Next-generation sequencing of microbial communities provides an …
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Recovery of Antibiotic Resistance Genes From Agricultural Runoff
The reduced capacity of antibiotics to treat infections is one of the greatest health concerns that society faces. There is substantial evidence that links this reduced capacity with the widespread use of antibiotics in livestock production. Livestock can act as reservoirs of antibiotic resistance …
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Domestic greywater systems: a potential reservoir of antibiotic resistance genes transfer
… however, has the potential to harbour residual antibiotics and pathogenic bacteria, thereby potentially supporting the growth and proliferation of antibiotic resistant bacteria. This study combined traditional microbiology tests with molecular biology to detect resistant microorganisms within …
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Improved monitoring of emerging environmental biocontaminants through (nano)biosensors and molecular analyses
… One such shift is the advent of the modern antibiotic era, in which mass production and outputs of antibiotics, which are mostly naturally-derived microbial defense compounds and include a few synthetic antimicrobials, has profound implications for contributing to the spread of antibiotic …
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Developing a Computational Pipeline for Detecting Multi-Functional Antibiotic Resistance Genes in Metagenomics Data
Antibiotic resistance is currently a global threat spanning clinical, environmental, and geopolitical research domains. The environment is increasingly recognized as a key node in the spread of antibiotic resistance genes (ARGs), which confer antibiotic resistance to bacteria. Detecting ARGs in the …
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A Study of Antibiotic Resistance Plasmids in Fresh Produce and In Wastewater Environments Using Functional Approaches, Comparative Genomics and Abundance Analysis
… that a major reservoir of clinically relevant antibiotic resistance genes (ARGs) is found in non-pathogenic environmental bacteria. Ciprofloxacin, meropenem and erythromycin are important clinical antibiotics due to their broad applications in the treatment of Gram-positive and Gram-negative …
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Effects of Anaerobic and Aerobic Digestion at Mesophilic and Thermophilic Temperatures on the Quantity of Carbapenem Resistance Genes in Wastewater Sludge
Antibiotic resistance genes (ARGs) encode resistance against antibiotic drugs in bacteria. Carbapenem antibiotics are one of the last lines of defence against bacterial infections and carbapenem resistance genes (CRGs) accumulate in sludge during wastewater treatment. Anaerobic and aerobic …
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Detection of antibiotic resistance genes in gardening composts
… used for gardening. To evaluate the risk of antibiotic resistance and potential pathogens in composts, two homemade composts, eight commercially available composts, and one immature swine mortality compost were collected and analyzed by high-throughput quantitative polymerase chain reaction …
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