Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"antibiotic discovery"”.
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Mechanistic investigations on polyprenyl transferases and multi-target antibiotic discovery
… prenyl transferases are druggable targets in antibiotic development. In Chapter 2, I discuss the new series of lipophilic bisphosphonates that inhibit the growth of various bacteria and target multiple prenyl transferases. To determine and verify the enzyme targets of antibiotic leads, enzyme …
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Approaches to investigating antibiotic efficacy and discovery of treatment strategies against antibiotic tolerance
While it is widely understood that antibiotic resistance is challenging the efficacy of our antibiotic therapies, there is a growing appreciation for the clinical importance of other ways that bacteria can survive antibiotic treatment. In particular, antibiotic tolerance describes a set of …
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Development of Computational Antibiotic Screening Platform Across Bacterial Outer Membrane Proteins
<p>Antibiotics are medicines used to treat bacterial infections by either killing bacteria or stopping them from reproducing. Throughout the use of antibiotics, bacteria has developed a variety of defense mechanisms against antibiotics and thus diminishing their effectiveness. Antibiotic resistance …
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Chemical approaches to understanding small-molecule accumulation in bacteria and poly(ADP-ribosyl)ation
The introduction of antibiotics revolutionized modern medicine. Surgical procedures became safer to perform, neonatal fatalities plummeted, and the risk of death from simple injuries was virtually eliminated. Since their initial discovery and introduction to the clinic in the 1940s, a steady supply …
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An evaluation of co-culture parameters effecting antibiotic production in soil microbes
<p>The rise of infections caused by antibiotic resistant bacteria, compounded by a reduction in antibiotic discovery and development, jeopardizes human health. Historically, antibiotics derive from secondary metabolites produced by soil microbes in pure culture, but recent genetic evidence suggests …
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Creating effective drug discovery methods in Mycobacterium abscessus
… emergence, the only way to ensure future antibiotic efficacy is through continued development of new drugs capable of evading resistance mechanisms. However, over the past 30 years the antibiotic drug development space has been characterised by the withdrawal of recourses, large …
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Repurposing Antibacterial Compounds and Natural Products to Combat Vancomycin-Resistant Enterococci
Antibiotic resistance is one of the greatest threats to modern medicine, leaving clinicians with shrinking treatment options for life-threatening infections. Among the most concerning pathogens are vancomycin-resistant Enterococcus (VRE), which causes serious bloodstream, urinary tract, and wound …
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Strategies for thiazole/oxazole-modified microcin discovery
… data has potential to be helpful for the discovery of novel compounds by using genome mining. Although strategies of genome mining have become more efficient and capable of identifying novel biosynthetic gene clusters, it remains difficult to correlate gene clusters with natural products. …
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Mangrolide A, A Novel Marine Derived Polyketide with Selective Antibiotic Activity
… of these molecules has been instrumental in the discovery of many medicinal compounds, especially to combat infections caused by pathogenic bacteria. Antibiotic resistance is a major challenge faced in hospitals today, and there is an urgent need for new antibiotics. The "Golden Age" of …
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Antibiotic Drug Discovery with an Eye Towards Overcoming Drug Resistance
… humans have become ever reliant on the use of antibiotics to facilitate our everyday lives. The widespread emergence of resistance to currently used antibiotics is commonly attributed to an over use in our society. Such resistance, coupled with a lack of innovation and production of novel …
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Evaluation of Antibiotic Production and its Regulation in Pantoea agglomerans Tx10
… is the enterobacterial genus Pantoea. Although antibiotic discovery efforts in Pantoea have focused largely on agricultural applications, Pantoea remains an unexplored reservoir of antibiotics that may have utilization in a clinical setting. Using an agar overlay assay, Pantoea agglomerans Tx10 …
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Bioengineering of nisin to enhance functionality against dairy pathogens
… the void created by the end of the golden age of antibiotic discovery. Along with this potential use in a clinical setting, bacteriocins also play an important role as bio-preservatives in the food industry. This thesis focuses on a specific bacteriocin group, the lantibiotics …
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Improving antibiotic activity by manipulating bacterial reactive oxygen species metabolism
The discovery of antibiotics was one of the most important medical breakthroughs of the twentieth century, having a broad impact on overall life expectancy and public health. Unfortunately, antibiotic discovery has slowed significantly in recent times and has failed to match the rising incidence of …
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Natural Product Discovery from a Streamline Environment-to-Bioassay Pipeline
… products (NPs) have long been central to drug discovery as sources of new therapeutics and drug leads. Despite major advances in microbial NP discovery over the past century, the earliest stages of the workflow—from sample collection to library generation—have remained largely unchanged. …
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Quinolone mechanism of action: sensitivity, mutagenesis and tolerance
Antibiotics are a foundation of modern medicine, helping to save millions of lives since their discovery in 1928. But the improper and excessive use of these drugs over the last few decades has led to an alarming increase in antimicrobial resistance; coupled with the recent decrease in antibiotic …
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Developing novel therapies for Mycobacterium abscessus
… to a wide range of the currently available antibiotic therapies. In particular, it causes problems in patients with Cystic Fibrosis (CF) with evidence of marked inflammation, frequent infective exacerbations and an accelerated decline in lung function. Current treatment outcomes are …
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Medical Microbiology: Discovery of New Antimicrobial Drugs to Treat Clinically Relevant Antibiotic Resistant Pathogenic Bacteria
… drug resistant infections. These actions include discovery of new antibiotics and community engagement in AMR. Natural product screening methods are arguably the most efficient way to identify novel antibiotics, but can be frustrated by the repeated discovery of known compounds, wasting valuable …
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Isolation and biological characterisation of plant-derived chemicals for antibacterial purposes in food animals and humans
… example of which would be the emergence of many antibiotic resistant strains of the methicillin resistant Staphylococcus aureus which is a worldwide epidemic. Pathogens such Listeria monocytogenes, Escherichia coli and Staphylococcus aureus have been the source of a variety of human and animal …
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Studies Towards the Discovery of Novel Natural Products Through Functional Analysis of Environmental DNA-Encoded Type II Polyketide Synthases
… methods. Most modern natural product discovery efforts are faced with the hurdle of high rediscovery rates (>99%) of known metabolites produced by easily cultured bacteria. Metagenomics has evolved as an alternative approach to conventional microbial screening. By directly cloning …